1.Systematic Evaluation of Elemene Combined with Radiotherapy for Intervention in Brain Metastasis from Pulmonary Neoplasms
heng Zhi CHI ; Shun YU ; ting Wen WEN
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(11):96-100
Objective To systematically evaluate the effectiveness and safety of Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms. Methods Articles of clinical randomized controlled trials about Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms from the establishment of the databases to October of 2016 from CNKI, CBM, Chongqing Weipu, Wanfang database, Cochrane Library, PubMed and Embase were retrieved by computers. Bias risk assessment tools in Cochrane systematic evaluation handbook 5.1.0 was used to conduct quality evaluation for included articles. RevMan5.3 software was used to carry out Meta-analysis. Results Totally 12 articles and 839 patients were included. Results of Meta-analysis showed that Elemene combined with radiotherapy had more obvious curative effect on narrowing the neoplasm compared with pure radiotherapy [OR=2.73, 95%CI (1.97, 3.77), P<0.000 01], and improve patients' life quality at the same time [OR=3.85, 95%CI (2.23, 6.65), P<0.000 01], and relieve adverse reactions [OR=4.16, 95%CI (2.40, 7.22), P<0.000 01]. Conclusion Elemene combined with radiotherapy for intervention in brain metastasis from pulmonary neoplasms shows confirmed efficacy, and is relatively safe. But whether the program should be widely used in clinic, more large sample, multi-center, and high-quality clinical randomized controlled trials are still needed.
2.Validation of Dose Conversion of Banxia Houpotang Based on Systematic Evaluation
Zheng SHI ; Ren-shou CHEN ; Jiang HAN ; Zhi-heng CHI ; Wen-ting WEN
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(6):178-184
There are many different opinions on dose conversion of famous classical formulas from
3.Epilepsy in Southeast Asia, how much have we closed the management gap in past two decades?
Kheng-Seang Lim ; Zhi-Jien Chia ; Moe-Zaw Myint ; Kazi Jannat Ara ; Yong-Chuan Chee ; Woon-Theng Heng ; Thanmidraaj-Kaur Balraj Singh ; Janice-Ying-Qian Ong ; Slocahnah SreeKumar ; Minh-An Thuy Lee ; Si-Lei Fong ; Chong-Tin Tan
Neurology Asia 2020;25(4):425-438
The last review on epilepsy in Southeast Asian (SEA) countries was reported in 1997. This review
aimed to update the understanding of epilepsy management in this region over the past 23 years. There
has been significant increase in the epidemiological studies which reported a prevalence of 4.3-7.7 per
1,000 populations in this region. Reversible aetiologies of epilepsy such as head injury, birth trauma,
cerebrovascular disease, and intracranial infections (neurocysticercosis or meningoencephalitis) are
still prevalent, with a surge in autoimmune encephalitis. There was a surge in genetic studies which
suggest ethnic variation. Treatment gap is still high especially in the rural and less developed areas,
and the availability and affordability of newer anti-epileptic drugs (AEDs) is still a major challenge
in SEA. Alternative medicine is a common practice but varies among different ethnic groups. AEDs
hypersensitivity especially on the association between HLA-B*1502 and carbamazepine-related severe
cutaneous reaction had been extensively studied and proven in nearly all SEA countries. However,
HLA-B*1502 screening is not widely available in SEA and the cost-effectiveness of the screening is
questionable. Stigma and its psychosocial consequences are still a major concern despite enormous
efforts to study the public attitudes towards epilepsy and change of epilepsy naming in a few countries.
The number and complexity of epilepsy surgery are progressing, but it is still under-utilized in many
SEA countries, related to cost, cultural perception and lack of facilities. More resources should also
be channelled in training adequate number of epileptologists who can spearhead epilepsy care around
the region, as well as public education and research in epilepsy. In conclusion, there is an increase in
epilepsy research in this region, gradual increase in trained neurologists and facilities, and efforts to
reduce the knowledge and treatment gap, but the epilepsy management gap is still a battle to fight.
4.Clinical treatment outcomes and their changes in extremely preterm twins: a multicenter retrospective study in Guangdong Province, China.
Bi-Jun SHI ; Ying LI ; Fan WU ; Zhou-Shan FENG ; Qi-Liang CUI ; Chuan-Zhong YANG ; Xiao-Tong YE ; Yi-Heng DAI ; Wei-Yi LIANG ; Xiu-Zhen YE ; Jing MO ; Lu DING ; Ben-Qing WU ; Hong-Xiang CHEN ; Chi-Wang LI ; Zhe ZHANG ; Xiao RONG ; Wei SHEN ; Wei-Min HUANG ; Bing-Yan YANG ; Jun-Feng LYU ; Hui-Wen HUANG ; Le-Ying HUO ; Hong-Ping RAO ; Wen-Kang YAN ; Xue-Jun REN ; Yong YANG ; Fang-Fang WANG ; Dong LIU ; Shi-Guang DIAO ; Xiao-Yan LIU ; Qiong MENG ; Yu WANG ; Bin WANG ; Li-Juan ZHANG ; Yu-Ge HUANG ; Dang AO ; Wei-Zhong LI ; Jie-Ling CHEN ; Yan-Ling CHEN ; Wei LI ; Zhi-Feng CHEN ; Yue-Qin DING ; Xiao-Yu LI ; Yue-Fang HUANG ; Ni-Yang LIN ; Yang-Fan CAI ; Sha-Sha HAN ; Ya JIN ; Guo-Sheng LIU ; Zhong-He WAN ; Yi BAN ; Bo BAI ; Guang-Hong LI ; Yue-Xiu YAN
Chinese Journal of Contemporary Pediatrics 2022;24(1):33-40
OBJECTIVES:
To investigate the clinical treatment outcomes and the changes of the outcomes over time in extremely preterm twins in Guangdong Province, China.
METHODS:
A retrospective analysis was performed for 269 pairs of extremely preterm twins with a gestational age of <28 weeks who were admitted to the department of neonatology in 26 grade A tertiary hospitals in Guangdong Province from January 2008 to December 2017. According to the admission time, they were divided into two groups: 2008-2012 and 2013-2017. Besides, each pair of twins was divided into the heavier infant and the lighter infant subgroups according to birth weight. The perinatal data of mothers and hospitalization data of neonates were collected. The survival rate of twins and the incidence rate of complications were compared between the 2008-2012 and 2013-2017 groups.
RESULTS:
Compared with the 2008-2012 group, the 2013-2017 group (both the heavier infant and lighter infant subgroups) had lower incidence rates of severe asphyxia and smaller head circumference at birth (P<0.05). The mortality rates of both of the twins, the heavier infant of the twins, and the lighter infant of the twins were lower in the 2013-2017 group compared with the 2008-2012 group (P<0.05). Compared with the 2008-2012 group, the 2013-2017 group (both the heavier infant and lighter infant subgroups) had lower incidence rates of pulmonary hemorrhage, patent ductus arteriosus (PDA), periventricular-intraventricular hemorrhage (P-IVH), and neonatal respiratory distress syndrome (NRDS) and a higher incidence rate of bronchopulmonary dysplasia (P<0.05).
CONCLUSIONS
There is a significant increase in the survival rate over time in extremely preterm twins with a gestational age of <28 weeks in the 26 grade A tertiary hospitals in Guangdong Province. The incidences of severe asphyxia, pulmonary hemorrhage, PDA, P-IVH, and NRDS decrease in both the heavier and lighter infants of the twins, but the incidence of bronchopulmonary dysplasia increases. With the improvement of diagnosis and treatment, the multidisciplinary collaboration between different fields of fetal medicine including prenatal diagnosis, obstetrics, and neonatology is needed in the future to jointly develop management strategies for twin pregnancy.
Bronchopulmonary Dysplasia/epidemiology*
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Female
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Gestational Age
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Humans
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Infant
;
Infant, Extremely Premature
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Infant, Newborn
;
Pregnancy
;
Respiratory Distress Syndrome, Newborn/epidemiology*
;
Retrospective Studies
;
Treatment Outcome