1.Discomfort of right eye and right maxilla region after dental implant placement: a case report.
Zhi-ying WANG ; Zhi-en FENG ; Zhi QU
West China Journal of Stomatology 2010;28(1):106-108
Discomfort of right eye and right maxilla region occurred after a dental implant placement in a patient who surfered stabilized osteofibrous dysplasia (OFD) of sphenoid sinus. In this article, the case was discussed and the relevant literature was reviewed. The possible causes of eye and maxilla discomfort may be associated with OFD, hyper allergic response to implant material and surgical trauma, and psychical factors as well.
Dental Implantation, Endosseous
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Dental Implants
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Humans
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Maxilla
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Maxillary Sinus
2.Overview of Pharmacological Research on Eggshell Membrane
Jiang GONG ; Shi-feng NI ; Xue-mei ZHANG ; Jia QU ; Rong-fang LUO ; Zhi-xuan LI ;
International Journal of Traditional Chinese Medicine 2009;31(2):187-188
In the basis of a large amount of literatures, this article sumed up the characteristics and application of eggshell membrane.
3.Research advances on the pathogenesis of acute pancreatitis
Zhi ZHENG ; Yuanxu QU ; Yixuan DING ; Wentong MEI ; Yuchen JIA ; Yulin GUO ; Feng CAO ; Fei LI
Chinese Journal of Hepatobiliary Surgery 2021;27(2):152-155
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Its pathogenesis is not only related to abnormal activation of trypsinogen, but also related to calcium overload, mitochondrial dysfunction, impaired autophagy and endoplasmic reticulum stress. However, the mechanism has not been fully elucidated and needs to be further studied. Currently, there is no effective treatment for AP. It is difficult to prevent the loss of pancreatic function. An in-depth understanding of the pathophysiological mechanisms of AP may help to identify the potential therapeutic targets. Therefore, the purpose of this study is to review recent advances in the mechanism of AP in order to provide more research direction for treatment.
4.Risk factors for patent ductus arteriosus in neonates.
Xiao-Yu QU ; Xian-Feng ZHOU ; Yi QU ; Bin-Zhi TANG ; De-Zhi MU
Chinese Journal of Contemporary Pediatrics 2011;13(5):388-391
OBJECTIVETo identify the risk factors for patent ductus arteriosus (PDA) in neonates.
METHODSFifty infants with PDA and 100 infants without PDA were enrolled. Chi-square test, Student's t test and the linear correlation analysis were used to study the clinical data. Logistic regression analysis was used to investigate the independent risk factors for PDA.
RESULTSThe prevalence of PDA was negatively correlated with the gestation age (r=-0.03, P<0.05) and birth weight (r=-0.04, P<0.05). Oxygen inhalation was a protective factor for the development of PDA. Fetal distress, meconium-stained amniotic fluid, oligohydramnios, cord entanglement, 1 minute Apgar score <8, maternal infection and hypoxic-ischemic encephalopathy were the independent risk factors for the development of PDA.
CONCLUSIONSThe incidence of PDA can be reduced by preventing maternal infection, premature birth, low birth weight and hypoxia.
Apgar Score ; Birth Weight ; Ductus Arteriosus, Patent ; etiology ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Male ; Risk Factors
5.Comparison of swing shoulder and internal fixation for the treatment of proximal humeral fractures in elderly.
Yong WANG ; Bing XU ; Zuo-qu YU ; Zhi-hua YU ; Shou-wang DAI ; Feng LI ; Yin-sheng WU
China Journal of Orthopaedics and Traumatology 2014;27(12):980-985
OBJECTIVETo compare clinical outcomes of swing shoulder and internal fixation in treating proximal humeral fractures.
METHODSFrom June 2007 to June 2012, totally 89 elderly patients with humeral proximal fractures were treated by swing of shoulder or internal fixation, and 81 patients were followed up. In swing shoulder group, there were 38 patients including 13 males and 25 females aged from 62 to 84 with an average of (67.11±6.18) years old; 27 cases were 2-part fractures and 11 cases were 3-part fractures according to Neer classfication. In internal fixation group, there were 43 patients including 16 males and 27 females aged from 60 to 80 with an average of (66.47±5.48) years old; and 29 cases were 2-part fractures and 14 cases were 3-part fractures according to Neer classfication. VAS score and complications were compared between two groups after treatment, and Constant-Murley functional scoring was used to evaluate shoulder function of patients.
RESULTSEighty-one patients were followed up from 13 to 26 months with an average of 18.3 months. There was no significant difference in preoperative VAS score between two groups. After treatment, VAS score in swing shoulder group was (3.11±0.95), and (3.88±1.14) in internal fixation group, and had significant difference between two groups (t=-3.313,P<0.05). There was no significant difference in Constant-Murley scores between swing shoulder group (79.53±3.73) and internal fixation group (77.98±4.11) (t=1.768,P>0.05). Postoperative complications in swing shoulder group was 18.4%(7/38), 39.5%(17/43) in internal fixation group, and had significant differences between two groups (χ2=4.313,P<0.05).
CONCLUSIONSwing shoulder for the treatment of proximal humeral fractures in elderly has advantages of low cost, less complications and good recovery of joint function; while internal fixation has a good therapeutic effect but increased complications.
Aged ; Aged, 80 and over ; Female ; Fracture Fixation, Internal ; adverse effects ; methods ; Humans ; Male ; Manipulation, Orthopedic ; adverse effects ; methods ; Middle Aged ; Shoulder Fractures ; therapy
6.Clinical analysis of 18 cases with solitary bone plasmacytoma
Zhi GUO ; Feng CHEN ; Dezhang MA ; Xuepeng HE ; Huiren CHEN ; Yukui ZHANG ; Bichuan HU ; Yan JI ; Rong QU
Cancer Research and Clinic 2010;22(4):222-224
Objective To improve the diagnosis level of solitary bone plasmacytoma (SBP) through analysing the clinical characteristics and therapy of this disease. Methods The clinical data of 18 cases were retrospectively analysis since 1999 in five hospitals, the clinical characteristics and therapeutic effect was summarized. Results The average age of 18 cases is 54.2 year (35-78), male were 1.6 times than female. 8 of 10 patients survived for 1-10 year after chemoradiotherapy, 2 of them progressed to multiple myeloma (MM)and died. 5 of 8 patients survived after only chemotherapy or radiotherapy. There were 11 cases of all patients in continue complete remission (CCS), the average CCS time was 47.3 months. Conclusion SBP is a type low-grade malignant tumor. Chemotherapy and radiotherapy is the main therapy. The patients can gain satisfactory prognosis with chemoradiotherapy, part of them can progress to MM.
7.Effect of lactulose on interleukin-18 madiatid multiple orgern function in severe burned rats.
Zhi WANG ; Cheng-Long HUANG ; Jing-Qu LIU ; Si-Quan LI ; Zheng-Long LI ; Jing-Gang HU ; Feng LIAN
Chinese Journal of Applied Physiology 2011;27(2):203-205
Animals
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Burns
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drug therapy
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metabolism
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physiopathology
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Interleukin-18
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genetics
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metabolism
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Lactulose
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therapeutic use
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Lipopolysaccharides
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blood
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Liver
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metabolism
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physiopathology
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Lung
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metabolism
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physiopathology
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Male
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Multiple Organ Failure
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prevention & control
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RNA, Messenger
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genetics
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metabolism
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Rats
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Rats, Wistar
8.The effect of the Mongolian medicine modified Tabusen-2 on kidney-yang deficiency in rats based on metabolomics
Zhi WANG ; Pei-feng XUE ; Cai-meng XU ; Kun WANG ; Rui DONG ; Qing-xiang SONG ; Bi QU ; Xin DONG
Acta Pharmaceutica Sinica 2022;57(11):3378-3386
We used metabolomics to investigate the ability of a traditional Mongolian medicine called modified Tabusen-2 (MT-2) to improve kidney yang deficiency (KYD) in rats. All animal experiments were conducted under the guidance and standards of the Medical Ethics Committee of Inner Mongolia Medical University. SD rats were divided into 6 groups of six rats: a normal group, a model group, Jinkuishenqi pill administration group (1.26 g·kg-1), and MT-2 administration in high-, medium- and low-dose groups (1.512, 0.756, and 0.378 g·kg-1). KYD was established by intramuscular injection of hydrocortisone (HC) and biochemical indicators and clinical characterization was used to confirm that KYD was established. All groups received intragastrically administered drug (Jinkuishenqi pill or MT-2) or saline. Serum from each group was collected after 8 weeks and analyzed by UPLC-Q-exactive-MS to measure various biochemical indicators. The biomarkers affected by MT-2 were identified and the metabolic pathways of KYD regulated by MT-2 were analyzed by metabolomic analysis. The results show that MT-2 can decrease serum creatinine (Cr) in KYD rats and significantly increase (
9.Research progress of Kruppel-like factor family in malignant tumors
Zhi ZHENG ; Yixuan DING ; Wentong MEI ; Yulin GUO ; Yuanxu QU ; Jiongdi LU ; Shuang LIU ; Haichen SUN ; Feng CAO ; Fei LI
International Journal of Surgery 2021;48(4):264-268
Malignant tumors usually have no obvious clinical symptoms in the early stage. Most patients are already in the advanced stage when they are diagnosed. Some patients have lost the opportunity for operation, resulting in poor prognosis. Therefore, how to find the best therapeutic target for such patients and improve the prognosis of patients has gradually become the focus of scholar′s attention. Recently, Kruppel-like factor (KLF) is a transcriptional regulator that can bind to the target DNA, and its family plays an important role in the occurrence and development of malignant tumors. It has also been confirmed that the KLF family affects the proliferation, differentiation and migration of tumor cells, but the specific mechanism is still not fully elucidate. Consequently, in order to further explored the effect of the KLF family on tumors, this study intends to briefly review the roles and regulatory mechanisms of the KLF family in the cell proliferation, differentiation and migration of malignant tumors, hoping to provide new target for the biological treatment of tumors.
10.Tripartite-motif protein 25 and pyruvate kinase M2 protein expression in non-small cell lung cancer.
Huai-Zhi JING ; Feng QIU ; Shi-Zhi CHEN ; Lin SU ; Can QU
Journal of Southern Medical University 2015;35(3):437-441
OBJECTIVETo investigate the expression of tripartite-motif protein 25 (TRIM25) and pyruvate kinase M2 (PKM2) protein in non-small cell lung cancer (NSCLC) and explore their role in the occurrence and progression of NSCLC.
METHODSThe expressions of TRIM25 and PKM2 protein were detected in 60 NSCLC specimens and 20 adjacent normal lung tissue (>5 cm from the lesions) with immunofluorescence histochemical method and in 10 fresh specimens of NSCLC with Western blotting. The results were analyzed in relation with the clinicopathological features of the patients.
RESULTSThe positivity rates of TRIM25 expression was 45% in the 60 lung carcinoma specimens, significantly higher than that in the 20 normal lung tissues (10%, P=0.005). TRIM25 protein was expressed in 28.6% of lung adenocarcinoma tissues and in 59.4% of squamous carcinoma tissues (P=0.017). TRIM25 protein expression was positively correlated with the TNM stages and lymph node metastasis of NSCLC (P<0.05). The expressions of PKM2 protein in 60 cases of lung carcinoma was 73.3%,while in 20 cases of normal lung tissues the expressions was 30%(P=0.001). The positivity rates of PKM2 expression differed significantly between lung adenocarcinoma and squamous carcinoma (57.1% vs 87.5%, P=0.008). An inverse correlation was noted between TRIM25 and PKM2 expressions (P=0.026).
CONCLUSIONTRIM25 and PKM2 protein may participate in the occurrence and progression of NSCLC, and their expressions are inversely correlated.
Adenocarcinoma ; enzymology ; Carcinoma, Non-Small-Cell Lung ; enzymology ; Carcinoma, Squamous Cell ; enzymology ; Carrier Proteins ; metabolism ; Humans ; Lung ; pathology ; Lung Neoplasms ; enzymology ; Lymphatic Metastasis ; Membrane Proteins ; metabolism ; Thyroid Hormones ; metabolism ; Transcription Factors ; metabolism ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases ; metabolism