3.Advances in high mobility group box-1 protein mediated multiple organ dysfunction and its potential interventional strategies.
Yong-ming YAO ; Shan XU ; Zhi-yong SHENG
Acta Academiae Medicinae Sinicae 2007;29(4):459-465
High mobility group box-1 protein (HMGB1) has recently been shown as a crucial late mediator of inflammation and sepsis, and is involved in mediating multi-organ functional lesions, including acute lung, liver, and intestine injuries. As a delayed inflammatory cytokine, HMGB1 provides a wider therapeutic time window for clinical intervention. HMGB1 has been proven to be a promising therapeutic target to prevent the development of multiple organ dysfunction syndrome in experimental models of severe sepsis. The pharmacological strategies include neutralization of antibodies or specific HMGB1 antagonists, suppression of HMGB1 secretion (ethyl pyruvate, agonists for alpha7-nicotinic acetylcholine receptors), and down-regulation of HMGB1 expression (sodium butyrate, signaling inhibitors for Janus kinase/signal transducer and activator of transcription).
HMGB1 Protein
;
antagonists & inhibitors
;
biosynthesis
;
physiology
;
Humans
;
Multiple Organ Failure
;
immunology
;
metabolism
;
prevention & control
;
Sepsis
;
immunology
;
metabolism
;
therapy
5.A Review on Relations Between Pathogenicity and Melanin of Plant Fungi
Zhi-Yan CAO ; Sheng-Yong YANG ; Jin-Gao DONG ;
Microbiology 1992;0(01):-
Melanin is formed by oxidative polymerization of phenolic compounds,basically different kinds of melanin come from different organisms.DOPA melanin and DHN melanin have same physical and chemical characters although they have different biosynthetic pathway.DHN melanin is common in plant fungi and plays an important role on infection.The melanin accumulates in the fungal cell walls and prevents organic and inorganic molecules penetrating out,that insures appressorium's pressure and infection ability.This paper has reviewed the kinds and characters,especially discussed the role of melanin during pathogen infection based on our some research.
6.Influence of AKT on survival and apoptosis of gastric adenocarcinoma cells.
Yong LIU ; Ming-zhi LU ; Si-si FAN ; Sheng YUAN
Chinese Journal of Pathology 2009;38(5):340-341
Adenocarcinoma
;
pathology
;
Apoptosis
;
drug effects
;
Cell Line, Tumor
;
Cell Survival
;
drug effects
;
Dose-Response Relationship, Drug
;
Humans
;
Nucleosides
;
administration & dosage
;
pharmacology
;
Proto-Oncogene Proteins c-akt
;
antagonists & inhibitors
;
Pyridazines
;
administration & dosage
;
pharmacology
;
Stomach Neoplasms
;
pathology
8.Study on DNA expression profiles in renal biopsies of patients with IgA nephropathy.
Feng LI ; Ying-hao YU ; Jing-sheng XU ; Feng-hua LAN ; Yong-ze ZHUANG ; Zhi-yong ZHENG ; Hua-sheng XIAO
Chinese Journal of Pathology 2009;38(5):342-343
Adult
;
Biopsy
;
DNA
;
genetics
;
Female
;
Gene Expression Profiling
;
Glomerulonephritis, IGA
;
genetics
;
pathology
;
Humans
;
Kidney
;
pathology
;
Male
;
Middle Aged
;
Young Adult
9.Novel insights for high mobility group box 1 protein-mediated cellular immune response in sepsis:A systemic review
Li-Feng HUANG ; Yong-Ming YAO ; Zhi-Yong SHENG
World Journal of Emergency Medicine 2012;3(3):165-171
BACKGROUND: High mobility group box 1 protein (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of nearly all cell types. HMGB1 is secreted into the extracellular milieu and acts as a proinflammatory cytokine. In this article we reviewed briefly the cellular immune response mediated by HMGB1 in inflammation and sepsis. METHODS: This systemic review is mainly based on our own work and other related reports. RESULTS: HMGB1 can actively affect the immune functions of many types of cells including T lymphocytes, regulatory T cells (Tregs), dendritic cells (DCs), macrophages, and natural killer cells (NK cells). Various cellular responses can be mediated by HMGB1 which binds to cell-surface receptors [e.g., the receptor for advanced glycation end products (RAGE), Toll-like receptor (TLR)2, and TLR4]. Anti-HMGB1 treatment, such as anti-HMGB1 polyclonal or monoclonal antibodies, inhibitors (e.g., ethyl pyruvate) and antagonists (e.g., A box), can protect against sepsis lethality and give a wider window for the treatment opportunity. CONCLUSION: HMGB1 is an attractive target for the development of new therapeutic strategies in the treatment of patients with septic complications.
10.Demonstration of Charcot-Leyden crystals by acid-fast stains applied on tissues.
Xian-min BU ; Li-qing YAO ; Zhi-yong ZHENG ; Xi-sheng XIONG
Chinese Journal of Pathology 2006;35(1):47-47
Crystallization
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Eosinophils
;
enzymology
;
Fascioliasis
;
pathology
;
Granuloma
;
pathology
;
Humans
;
Liver
;
pathology
;
ultrastructure
;
Lung
;
pathology
;
ultrastructure
;
Lung Diseases, Parasitic
;
pathology
;
Lysophospholipase
;
metabolism
;
Paragonimiasis
;
pathology