1.Variance of Helicobacter Pylori Infection Rate in Children with Recurrent Abdominal Pain
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To explore the variance of helicobacter pylori(Hp) infection rate in children with recurrent abdominal pain(RAP).Methods By using the()~(13)C-urea breath test(~(13)C-UBT) to detect the status of Hp infection in 1676 children with RAP from 1998 to 2004.Results 1.Total 1676 cases of children with RAP were detected.There were 438 cases showed Hp positive,the positive rate was 26.13%.The infection rates in patients from 2-5,5-10,and 10-14 years of age were 23.66%(84/355),(26.31%)(286/1087),29.06%(68/234),respectively.2.Hp infection rates in children with RAP from 1998 to 2004 were 29.33%(83/283),(28.90%)(76/263),25.76%(51/198),26.01%(56/215),25.81%(48/186),24.45%(67/274),22.18%(57/257),respectively.Conclusion 1.The Hp infection rate in children with RAP increased with age;2.The Hp infection rate in children with RAP decreased year after year.
4.Detection and comparison of plasma calprotectin in different stages of diabetic retinopathy in patients with type 2 diabetes mellitus
Chinese Journal of Experimental Ophthalmology 2012;30(4):367-370
BackgroundThe neutrophils infiltration and vascular endothelium damage are found in the patients with diabetic retinopathy (DR).Calprotectin existes in the cytosol outside lysoome.It is thought to be a marker of inflammation.The effect of calprotectin in the development of DR is still in the study. Objective This study was to investigate the contents of plasma calprotectin in different stages of DR in patients with type 2 diabetes mellitus. Methods This was a case-control study.Sixty consecutive patients with type 2 diabetes mellitus were enrolled in this study.The patients were assigned to non-DR (NDR) group,non-proliferative DR (NPDR) group and proliferative DR (PDR)group according to fundus appearance and fundus fluorescein angiography(FFA) manifestation and 20 patients for each group.Twenty healthy subjects matched in gender,age and blood biochemical indicators were collected as the normal control group.The periphery blood samples were collected from the subjects for the detection of plasma calprotectin by ELISA.The plasma calprotectin levels were compared among different stages of DR and normal subjects.All subjects had signed informed consents.Results The contents of plasma calprotectin were (57.70±12.29 ),( 72.07± 10.14 ),( 87.70 ± 10.37 ),( 94.36 ± 9.40 ) ng/L in the normal control group,NDR group,NPDR group,PDR group respectively,with a statistically significant difference among 4 groups (F =73.09,P<0.001 ).The content of calprotectin in PDR group showed a highest value in comparison with normal control group,NDR group and PDR group(q =20.157,10.648,4.497,P<0.01 ).The content of calprotectin in NPDR group was significantly higher than that in NDR group( q=6.216,P<0.01 ). ConclusionsPlasma calprotectin may play a role during the development of DR in type 2 diabetes mellitus patient.
5.Expressions of hepatocyte growth factor and its receptor protein in human thyroid neoplasms
Li-Zhi SHANG ; De-Xiang LI ; Jun-Lian QIN ;
Chinese Journal of Endocrinology and Metabolism 2000;0(06):-
The expressions of hepatocyte growth factor (HGF) and its receptor (c-Met) protein were examined by immunohistochemistry in benign and malignant thyroid neoplasms.The results showed that the positive rates of HGF and c-Met protein expressions in thyroid carcinomas were significantly higher than those of thyroid adenomas,and especially the expressions of HGF and c-Met proteins in follicular thyroid carcinomas were significantly higher than those in follicular thyroid adenomas.There existed significantly positive correlation between the expression degrees of HGF and c-Met in follicular thyroid carcinoma.Thus,the expressions of HGF and c-Met may be valuable in predicting prognosis of thyroid carcinomas and differentiating benign from malignant thyroid neoplasms.
6.Relationship between adrenomedullin and diabetic tubulointerstitial injury
Ji-Xiang DONG ; Jun LI ; Ying XIE ; Zhi-Min MA ;
Chinese Journal of Endocrinology and Metabolism 1985;0(02):-
Forty-two patients with type 2 diabetes mellitus (DM) were refered to 3 groups:type 2 DM without diabetic nephropathy (DN),type 2 DM with DN in the initial stage and type 2 DM with DN in the clinical stage.Ten healthy subjects were served as control group.Plasma adrenomedullin (ADM),urinary?_1- microglobulin (MG) and?_2-MG were detected.The results showed that the level of plasma ADM rose gradually with the development of DN and was positively correlated with markers of tubulointerstiial injury such as urinary?_1- MG and?_2-MG (both P
8.Analysis of clinically diagnosed upper gastrointestinal GVHD and effect of small-dose corticosteroid therapy after related hematopoietic stem cell transplantation.
Li-hong WANG ; Han-yun REN ; Zhi-xiang QIU
Chinese Journal of Hematology 2011;32(2):118-119
Adolescent
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Adult
;
Blood Donors
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Child
;
Child, Preschool
;
Female
;
Gastrointestinal Diseases
;
drug therapy
;
etiology
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Graft vs Host Disease
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drug therapy
;
etiology
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Hematopoietic Stem Cell Transplantation
;
adverse effects
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Hormones
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administration & dosage
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therapeutic use
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Humans
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Male
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Middle Aged
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Transplantation, Homologous
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Young Adult
9.Significance of melanocytes in diagnosis of congenital and acquired cholesteatoma.
Geng-Ming CAI ; Zhi-Chun LI ; Zi-Xiang YI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(2):147-148
Adolescent
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Adult
;
Aged
;
Cholesteatoma, Middle Ear
;
congenital
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pathology
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Female
;
Humans
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Male
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Melanocytes
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Middle Aged
;
Young Adult
10.The effects of mild hypothermia on the expression of myeloperoxidase and cyclooxygenase 2 in rats after cerebral ischemia and reperfusion
Zhi-Chao LIU ; Cheng-Yan LI ; Qiu-Xiang CHENG ;
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(12):-
Objective To investigate the effects of mild hypothermia ( MH ) on the expression of my- eloperoxidase(MPO) and cyclooxygenase 2 (COX 2) in rats after cerebral ischemia and reperfusion (CIR). Methods Forty-eight Wistar rats were randomly divided into four control groups (n=6 in each) and four MH groups (n=6 in each).CIR models were established by suture occlusion of the left middle cerebral artery.The rats in the MH groups,but not in the control groups,were treated with MH.Rats were killed at 4 h,8 h,12 h and 16 h after CIR.MPO expression was measured,along with the expression of COX 2 as measured by Western blot- ting and immunohistochemical methods.Results Compared with the control groups,MPO activity and the COX 2 expression in the cortex and striatum were significantly lower in all the MH groups at 4 h,8 h,12 h and 16 h after CIR.Conclusion MH treatment can protect neurons by decreasing MPO activity and COX 2 expression,allevia- ting inflammation and reducing secondary injuries after CIR.