1.Blastic plasmacytoid dendritic cell neoplasm: report of a case.
Chinese Journal of Pathology 2011;40(10):710-711
Aged
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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CD4 Antigens
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metabolism
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CD56 Antigen
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metabolism
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Cyclophosphamide
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therapeutic use
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Dendritic Cells
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pathology
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Diagnosis, Differential
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Doxorubicin
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therapeutic use
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Female
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Humans
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Leukemia, Myeloid
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metabolism
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pathology
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Lymphoma, Extranodal NK-T-Cell
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metabolism
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pathology
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Plasmacytoma
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drug therapy
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metabolism
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pathology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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metabolism
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pathology
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Prednisone
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therapeutic use
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Skin Neoplasms
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drug therapy
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metabolism
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pathology
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Vincristine
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therapeutic use
2.Effect of Shenkangling on Inflammatory State and Residual Renal Function in Patients with ;Maintenance Hemodialysis
Zhi ZHANG ; Hongjuan LIANG ; Jisheng WANG
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(2):36-39
Objective To observe the inflammatory state and residual renal function (RRF) of the patients with maintenance hemodialysis treated through Shenkangling. Methods Sixty patients with maintenance hemodialysis were randomly divided into two groups, the observation group (30 cases) and the control group (30 cases). They were treated through hemodialysis and hemodiafiltration. The patients in the observation group were treated with Shenkangling 8 tablets/time, 3 times/day. RRF and urine volume after six months were evalued. Serum high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and leukocyte mediated IL-6 (IL-6) before and after treatment were detected. Results There were no statistical differences in RRF and urine volume between the two groups before treatment (P>0.05). After six months, RRF and urine volume in the two groups were significantly reduced (P<0.05), and those of the observation group were significantly higher than those of the control group (P<0.05). There was no statistical significance in serum hs-CRP, TNF-α and IL-6 between the two groups before treatment (P>0.05). After treatment, the serum levels of hs-CRP, TNF-α, IL-6 significantly decreased in the observation group, and lower than those of the control group (P<0.05). Conclusion Shenkangling can protect the residual renal function of hemodialysis patients, and reduce the inflammatory reaction.
3.Preliminary observations of differentially expressed genes in cholangiocarcinoma
Zhigang TIAN ; Zhi XU ; Liang ZHANG
Chinese Journal of Minimally Invasive Surgery 2001;0(05):-
Objective To analyze differentially expressed genes between hilar and distal cholangiocarcinoma and to clarify the molecular mechanism of tumorigenesis. Methods Gene-expression profiles of 3 samples of hilar cholangiocarcinoma and 4 samples of distal cholangiocarcinoma were analyzed using oligo microarray containing 21 329 genes. The differentially expressed genes between the two groups were analyzed using the Significance Analysis of Microarrays (SAM) in order to get the specifically differentially expressed genes. The gene expression presence was verified by real-time PCR (RT-PCR). Results A total of 725 genes of cholangiocarcinoma was regulated significantly compared to normal bile duct. Of them, 244 genes were upregulated and 399 genes were downregualted in both groups; on the other hand, 82 gene expressions between hilar and distal cholangiocarcinoma had significant differences (ratio ≥ 2.0 or ≤ 0.5). The SAM analysis showed that 40 genes, including AREG, EPHA2, SPP1, PACE4, and so on, were identified as differentially regulated between the two groups (q=0). Conclusions These data are helpful for a better understanding of the tumorigenesis of cholangiocarcinoma and contribute to the development of diagnostic and therapeutic strategies. The gene expressions between hilar and distal cholangiocarcinoma are significantly different, which suggests that the two tumors have different molecular mechanisms of tumorigenesis.
5.One case report of systemic onset juvenile idiopathic arthritis with atlantoaxial subluxation as the initial manifesta-tion
Zhi LIN ; Zhihui LI ; Yi ZHANG ; Liang ZHANG ; Mai XUN
Journal of Clinical Pediatrics 2016;(2):139-141
Objective To explore the clinical features of systemic onset of juvenile idiopathic arthritis (SoJIA) with atlantoaxial subluxation as the initial manifestation. Methods The clinical data from one SoJIA patient with atlantoaxial subluxation as the initial manifestation were retrospectively analyzed. Results A 9-year-old boy presented the head and neck movement disorder as the ifrst symptom, developed fever on the third day, then rapidly progressed on 23rd day, with a sharp decline in red blood cell, platelet, and hemoglobin, blood coagulation dysfunction, and a large number of bilateral pulmonary exudation. Ultrasonography showed excess lfuid in abdomen, chest, and pericardium. According to the 2001 version of the revised International College of Rheumatology standard, the diagnosis of SoJIA combined macrophage activation syndrome was conifrmed. Then treated with hemoperfusion, ifltration, and methylprednisolone combined with cyclosporine A, the disease was in remission. Conclusion For children with spontaneous atlantoaxial subluxation accompanied by the systemic symptoms, with no obvious skeletal deformity or acute inlfammation etc., should be alerted to the consideration of systemic juvenile idiopathic arthritis.
6.Analysis of the survey result of the coal-burning endemic fluorosis in Hongya County of Sichuan Province in 2006
Liang, ZHANG ; Zhi-ming, YANG ; Zi-jiang, WU ; Zhi-yu, LUO ; Qiong, YAN ; Jian, ZHANG
Chinese Journal of Endemiology 2008;27(2):191-193
Objective To investigate the current status of coal-burning endemic fluorosis and the fluoride content in foods and drinking water in Hongya County,Sichuan Province.Methods Dental fluorosis and urinary fluoride were suveyed in children of 8~12 years old in two schools which repectively located in Gaomiao and Wawushan Town.The adults above 20 years old underwent clinical examination.At the same time,fifty adults above 20 years old in Garden Village were chosen to take forearm and calf X-ray films to find out the evidence of skeletal fluorosis.The content of fluoride in food such as bacon,corn,dry capsicum in Sanxing Village in Gaomiao Town and Futian Village in Wawushan Town as well as drinking water in five families in Sanxing Village were determined.Results The dental fluorosis rate of children was 40.76%(161/395),the dental fluorosis index was 0.86 in Gaomiao Town.The dental fluorosis rate of children was 14.36%(82/571),the dental fluorosis index was 0.31 in Wawushan Town.The medium value of the urine fluoride was 0.81 mg/L.ranged 0.16~3.89 mg/L.The positive rate oi the clinical examination of skeletal fluorosis was 5.27%(27/512),the X-rays detective rate was 4.00%(2/50).The medium value in bacon,corn,dry capsicum were 6.00,0.64,1.49 mg/kg.The averaged content of the fluoride in drinking water(0.14±0.06)mg/L of local household was within the eligible limitation.Conclusions It is currently a mild endemic disease in Hongya Country,its incidence is reduced apparently,pathogenetic environmental fluoride content is reduced.The main source of fluoride is from the preserved ham contaminated with fluoride,which is epidemiologically significant in endemic area of Hongya County.Defluoriding countermeasures should be taken in the endemic areas.
7.Advance in pulmonary adenocarcinoma with micropapillary pattern.
Jing ZHANG ; Zhi-yong LIANG ; Tong-hua LIU
Chinese Journal of Pathology 2011;40(3):202-205
Adenocarcinoma
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drug therapy
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genetics
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metabolism
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pathology
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surgery
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Adenocarcinoma, Bronchiolo-Alveolar
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drug therapy
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genetics
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metabolism
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pathology
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surgery
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Adenocarcinoma, Papillary
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metabolism
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pathology
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Cadherins
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metabolism
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Diagnosis, Differential
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Genes, erbB-1
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genetics
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Humans
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Lung Neoplasms
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drug therapy
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genetics
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metabolism
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pathology
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surgery
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Lymphatic Metastasis
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Mucin-1
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metabolism
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Mutation
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Neoplasm Invasiveness
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beta Catenin
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metabolism
8.Advance in biomarkers of lung cancer in diagnosis and targeted therapy.
Jing ZHANG ; Zhi-yong LIANG ; Xuan ZENG ; Tong-hua LIU
Chinese Journal of Pathology 2009;38(8):564-567
Acid Anhydride Hydrolases
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metabolism
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Apoptosis
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Biomarkers, Tumor
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metabolism
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Caspases
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metabolism
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Cell Adhesion Molecules
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metabolism
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Chromosome Deletion
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Drug Delivery Systems
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GPI-Linked Proteins
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metabolism
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Humans
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Hyaluronoglucosaminidase
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metabolism
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In Situ Hybridization, Fluorescence
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methods
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Lung Neoplasms
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diagnosis
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drug therapy
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genetics
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metabolism
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Neoplasm Proteins
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metabolism
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Neoplasm Staging
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Receptor, Epidermal Growth Factor
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metabolism
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Vascular Endothelial Growth Factor A
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metabolism
10.Experience on epidermal growth factor receptor gene mutation analysis in non-small cell lung cancer.
Jing ZHANG ; Jie GAO ; Zhi-yong LIANG ; Tong-hua LIU
Chinese Journal of Pathology 2011;40(10):712-714
Carcinoma, Non-Small-Cell Lung
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genetics
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metabolism
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pathology
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DNA Mutational Analysis
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DNA, Neoplasm
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genetics
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isolation & purification
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Genes, erbB-1
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Humans
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Lung Neoplasms
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genetics
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metabolism
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pathology
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Mutation
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Paraffin Embedding
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methods
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Polymerase Chain Reaction
;
methods
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Real-Time Polymerase Chain Reaction
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methods
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Receptor, Epidermal Growth Factor
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genetics