1. Expression of Bcl-2 and Bax protein in contusive brain tissue in patients of different ages
Academic Journal of Second Military Medical University 2010;28(10):1113-1115
Objective: To study the influence of different ages on expression of Bcl-2 and Bax protein in the contusive brain tissues after traumatic brain injury (TBI), so as to probe into the molecular mechanism of the age influence on the prognosis of TBI patients. Methods: The expression of Bcl-2 and Bax protein in contusive and lacerated brain tissue (within 3 h to 9 h after trauma) in aged group (≥ 60 years), adult group (19-59 years) and non-adult group (≤18 years) was analyzed and compared by immunohistochemistry method and computer micrograph analysis. The temporal lobe samples of 15 patients with temporal epilepsy or vascular deformity were taken as control. Results: The expression of NGF, Bcl-2 and Bax protein in the contusive and lacerated brain tissue was higher in the 3 TBI groups than that in the control group. The ratio of Bcl-2/Bax expression in aged group was significantly lower than those in the adult and non-adult groups (P <0.05); and the ratio of Bcl-2/Bax expression in the adult group was significantly lower than that in the non-adult group (P<0.05). Conclusion: The expression of Bcl-2 and Bax protein after TBI is influenced by the age of sufferers; the decrease of Bcl-2/Bax ratio might be associated with the neurological deficits after TBI in aged patients and the higher ratio of Bcl-2/Bax might be associated with the better prognosis of TBI in non-adult patients.
3.Development of POCT and medical digital assistant for primary medical healthcare.
Jun SHI ; Zhuang-Zhi YAN ; Zhi-Hao PAN
Chinese Journal of Medical Instrumentation 2008;32(1):40-46
In this paper, we discuss the meaning, advantages and methods of applying the point of care testing (POCT) and medical digital assistant (MDA) to primary healthcare services. We also introduce the development of the POCT and MDA based on the electronic health record(EHR) system.
Computers, Handheld
;
Medical Records Systems, Computerized
;
instrumentation
;
Point-of-Care Systems
;
Software Design
4.Effects of transcatheter arterial chemoembolization in combination with portal vein chemotherapy on survival of patients after resection of hepatocellular carcinoma
Jianbin ZHUANG ; Yijun WANG ; Zhi DU ; Fuhua NIE ; Guiming SHU ; Jun WANG ; Chengjun LU ; Qiang YUAN
Chinese Journal of Hepatobiliary Surgery 2010;16(8):579-581
Objective To study the value of transcatheter arterial chemoembolization (TACE)in combination with portal vein chemotherapy (PVC) after resection of hepatocellular carcinoma to prolong survival. Methods From January 2000 to July 2007, 168 patients with hepatocellular carcinoma (HCC) underwent tumor resection in our hospital. After operation, TACE in combination with PVC was performed in 48 patients (combined group), TACE alone in 26 (TACE group), PVC alone in 50 (PVC group) and none of the above in 44 (control group). All the patients were followed up for 17-96 months. The 1-, 3-and 5-year survival rates were compared among the 4 groups. Results Accumulative 1-, 3-and 5-year survival rates were higher in the combined and TACE groups than in PVC and control groups. Conclusion After resection of HCC, combined use of TACE and PVC is the same as TACE in prolonging patient survival. However, it is better than PVC alone and non-surgical procedure.
5.Design of the wireless medical information system based on PDA.
Tian-Long SHEN ; Jun SHI ; Zhuang-Zhi YAN
Chinese Journal of Medical Instrumentation 2007;31(5):344-347
This paper introduces the design of the wireless medical information management system based on PDA and its model whose experiment results show that it can realize the functional requirements of the design.
Computers, Handheld
;
Information Systems
;
instrumentation
;
organization & administration
;
Medical Informatics Applications
;
Signal Processing, Computer-Assisted
;
Software Design
;
Wireless Technology
6.Design of the Medical Digital Assistant for "bottom of the pyramid".
Jie-hui JIANG ; Zhuang-zhi YAN ; Jun SHI
Chinese Journal of Medical Instrumentation 2006;30(3):173-191
To meet the challenges such as raising the efficiency of medical resources, slowing the fastly-increasing medical costs and keeping the sustainability of the aging society and chronic diseases, this paper introduces a Medical Digital Assistant system for "BOP", which includes a mobile monitoring unit,a data transferring unit, and a managing unit, and presents the system's evaluating method. In addition, a new application model and the service workflow are discussed.
Computer Communication Networks
;
instrumentation
;
Computer Systems
;
Equipment Design
;
Hospital Information Systems
;
Humans
;
Image Processing, Computer-Assisted
;
instrumentation
;
Rural Health Services
;
Software Design
;
Telemedicine
;
instrumentation
;
methods
7.Design of the software system of the platform for long-term blood pressure monitoring.
Yan-ya LU ; Jun SHI ; Zhuang-zhi YAN ; Juan LI
Chinese Journal of Medical Instrumentation 2008;32(5):328-379
In this study, a platform for long-term and non-invasive blood pressure monitoring is proposed, Its software system and the functions of different program modules in the software system are introduced together with the development methods of the main modules.
Blood Pressure Determination
;
instrumentation
;
methods
;
Blood Pressure Monitors
;
Software Design
8.Inhibitory effect of?-ray irradiation on rat vascular smooth muscle cells
Yong-Zhi ZHUANG ; Jun-Jie WANG ; Xin-Chen SUN ; Ting-Zhen JIA ;
Chinese Journal of Radiation Oncology 1992;0(01):-
Objective To investigate the mechanism of the inhibitory effect of ?-ray irradiation on rat vascular smooth muscle cells(VSMC). Methods The ef fect of ?-ray irradiation on proliferation of VSMC was observed by 3?H-TdR incor poration. After ?-ray irradiation, the VSMC cell cycle change was detected b y flo w cytometry. The expression of p53, cyclin D and PCNA was investigated by Wester n Blot. Results The inhibitory effect of ?-ray irradiation on VSMC proliferati on was dose-dependent. After ?-ray irradiation, VSMC was arrested in G 1 st age, w ith the expression of p53 increased but the expression of cyclin D and PCNA decr eased. Conclusions ?-ray irradiation can inhibit the proliferation of VSMC. T he main mechanism is probably due to the induction of cell cycle arrest and inhi bition of the VSMC mitosis ,during which process, p53,cyclin D and PCNA all pla y an important role .
9.A web-based biomedical image mosaicing system.
Meng ZHANG ; Zhuang-zhi YAN ; Zhi-jun PAN ; Shi-jie SHAO
Chinese Journal of Medical Instrumentation 2006;30(6):419-456
This paper describes a web service for biomedical image mosaicing. A web site based on CGI (Common Gateway Interface) is implemented. The system is based on Browser/Server model and is tested in www. Finally implementation examples and experiment results are provided.
Internet
;
standards
;
Programming Languages
;
Radiology Information Systems
;
Software
10.Medical product designing model for the "BOP" in China.
Xie-hui JIANG ; Zhuang-zhi YAN ; Jun SHI ; N R WANIGASEKARA
Chinese Journal of Medical Instrumentation 2006;30(1):22-24
China has a large population under the average economy. This group of people is often referred to those at the Bottom of the Pyramid (BOP). In order to meet their special medical needs, this paper is to discuss a topic on how to create medical products for the "BOP" in China, especially under sustainable developments based on the investigation and analysis in Shanghai. Also, a new possible development model including the government's support, knowledge exchange and communication is introduced.
China
;
Delivery of Health Care
;
economics
;
Equipment and Supplies
;
Medical Indigency
;
Poverty