AIDS has become a global disease,and a variety of drugs are used in the treatment of AIDS ,but the interindividual variabilities in efficacy and toxicity remain important limitations for the use of these drugs.Studies have shown genetic polymor-phism is the main reason for interindividual variabilities of drug reaction.In recent years,scholars focused on the pharmacog-enomics of anti-AIDS drugs and found that genetic polymor-phisms,in large part,determine the interindividual variabilities of the responese of these drugs.This paper reviews the research progress on pharmacogenomics of the four types of anti-AIDS drugs commonly used in China,including nucleoside reverse transcriptase inhibitors (NRTIs),non-nucleoside reverse tran-scriptase inhibitors (NNRTIs),protease inhibitors (PIs)and integrase inhibitors (raltegravir).

Cyclin-Dependent Kinase Inhibitor p16 ; metabolism ; Female ; Genes, p16 ; Genes, p53 ; Humans ; Hysterectomy ; methods ; Ki-67 Antigen ; metabolism ; Leiomyoma ; genetics ; metabolism ; pathology ; surgery ; Leiomyosarcoma ; genetics ; metabolism ; pathology ; surgery ; Prognosis ; Smooth Muscle Tumor ; genetics ; metabolism ; pathology ; surgery ; Tumor Suppressor Protein p53 ; metabolism ; Uterine Neoplasms ; genetics ; metabolism ; pathology ; surgery

With development of wide-host-range vector systems,Tn5 transposon and its derivative vectors have been widely applied to genetic research of gram-negative bacteria.The applications of Tn5 transposon mutagenesis technology to genetic researches of bacteria were briefly discussed,including researches on biological control mechanisms of biocontrol bacteria,identification of bacterial essential genes,discovering virulence genes of bacterial pathogens,characterization of metabolism regulatory genes and genetic improvements of bacteria.

Objective To synthesize a novel polymer POMs-CS/nano-HAP and study its biocompatibility and safety.Methods The biocompatibility was evaluated through the experiments including acute systemic toxicity test,pyrogen,intracutaneous test.Results The crystals of POMs-CS/nano-HAP were equal on sizes, which average diameter was 20 nm and length was 100 nm.By comparing,the polymer were better than those reported,which were closer to the natural bone.The material had no toxicity,no irritation to skin.(Conclusion The) POMs-CS/nano-HAP artificial bone possesses excellent biocompatibility.

Child ; Embolization, Therapeutic ; adverse effects ; methods ; Female ; Humans ; Male ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic ; blood ; therapy ; Splenic Artery

Glioma ; pathology ; Humans ; Neoplastic Stem Cells ; pathology

Objective To survey on present situation of medical students' study style and to provide references to improve the development of study style. Methods Totally 512 undergraduate stu-dents of one medical university in Tianjing were asked to fill the questionnaire by themselves. Main con-tents of the questionnaire included study targets,study attitudes,study methods,teaching level,teaching equipments,school training system and management system,etc. Epidata3.02 was used to accomplish data entry and SPSS software was used to do statistical analysis. The data were described by percentage. Results More than 50.0% students took attending post-graduate examination,passing college English test band 4 and band 6 and getting diploma as main study purposes. 81.96%(404/499)medical stu-dents spent their spare time on study by themselves. 98.40%(491/499)students took notes in class,while only 8.62%(43/499)students often discussed questions with their teachers after class. 70.54%students said that they ever attended academic lectures organized by college and achieved benefits from them. 40.88%(204/499)students were highly eager to win scholarship. More than half of the students took gloomy atti-tude towards getting a job and this phenomenon should cause educators' attention. 78.56%(392/499 ) students held the opinion that medical professional teachers have higher teaching level and 26.65%(133/499 ) students thought that college's teaching equipments should be improved . Conclusions Following aspects should be emphasized in order to further strengthen and improve medical students' study style:making further efforts to arouse students' study initiative,playing the leading role of teach-ers and promoting study style by promoting teaching style,improving rules and regulations of study style development and strengthening college's hardware construction.

Objective To investigate the effect of Hedysarum Polybotys saccharide(HPS)on insulin resistance rats.Methods The model of type 2 diabetic-insulin resistance rat was successfully made by STZ and high caloric diet.Then the rats were intervene by Metformin(MT)and HPS.Results Compared with the model group,the level of blood glucose,INS and CP were lowered,ISI were improved and FFA were restrained by HPS.Conc(?)sion HPS can reduce the insulin resistance in multiple ways.

In order to cultivate advanced person with ability,we should teach students some theoretics and more practical skill during microbiology teaching. after we using the measures “examining on theoretics and practical skill that must be mastering in the lesson”. Students had been more interested in microbiology,and advanced of knowledge. So “examining on theoretics and practical skill that must be mastering in the lesson” is better method in teaching of Microbiology in Occupation technique college.

The viable but noncuturable (VBNC) state is a survival strategy when bacteria are exposed to en- vironment stress. The VBNC state is part of the life cycle of non-differentiating bacteria, and it has a far-reaching impact on traditional bacteriology. Cells in the VBNC state fail to grow on the routine bacterio- logical media, here its significance in human health and environment science are detailed. Cells entering the VBNC state exhibit dwarfing and a number of metabolic changes in respiration rates and macromolecular synthesis. This paper summarized the variations in DNA and protein comparing to the culturable cells. We also discussed the ability of cells to resuscitate from the VBNC state and return to an actively metabolizing and culturable form. Some new methods for monitoring the VBNC state were listed. Finally the future was suggested.