Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.

Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(?~(2)=10.94,P

Objective To clarify the frequency, the routes of transmission from mother to infant, the correlation factors and distribution of genotypes of transfusion transmitted virus (TTV) infection. Methods Nested polymerase chain reaction (n PCR) was performed to detect TTV DNA and genotypes in serums and breast milks from 160 cases of pregnant women. Results TTV DNA in serum and breast milk was detected in 64 (40 0%) and 60 (37 5%) of 160 cases of pregnant women respectively. The positive rates of TTV DNA from HBV markers (+) and normal groups were 50 0%, 43 1% and 13 6%, 22 7% respectively in serums and breast milk. There were significant difference between the two groups ( P

Enterocolitis, Necrotizing ; diagnostic imaging ; Humans ; Infant, Newborn ; Male ; Radiography

Hepatitis C, Chronic ; etiology ; pathology ; therapy ; Humans ; Recurrence

Face ; blood supply ; Hemangioma ; classification ; diagnosis ; therapy ; Humans ; Jaw ; blood supply ; Lymphatic Abnormalities ; classification ; diagnosis ; therapy ; Mouth ; blood supply ; Vascular Malformations ; classification ; diagnosis ; therapy

Face ; blood supply ; Hemangioma ; therapy ; Humans ; Vascular Malformations ; therapy ; Vasculitis ; therapy

Dental Implantation ; methods ; Humans ; Jaw ; physiology ; surgery ; Reconstructive Surgical Procedures ; methods

Accidents, Occupational ; prevention & control ; Causality ; Humans ; Occupational Diseases ; etiology ; prevention & control ; Risk Assessment

Gastroesophageal reflux disease and sliding hiatal hernia are chronic disease,and sometimes there are not typical clinical symptoms.Patients don't have enough cognition or put enough em-phasis on it.Determining the sliding length of the sliding hiatal hernia and gastroesophageal reflux disease respectively by means of high resolution manometry and 24 hour pH monitoring,in turn,analyzing the rela-tionship between sliding length of the sliding hiatal hernia and gastroesophageal reflux disease.