1. The cross-section study on warfarin anticoagulation effects with amiodarone's combination in different CYP2C9 and VKORC1 status
Chinese Pharmaceutical Journal 2013;48(24):2150-2153
OBJECTIVE: To analyse the effect of amiodarone on the warfarin anticoagulation effects in different CYP2C9 and VORCORC1 status. METHODS: From January 2010 to November 2012, patients on warfarin therapy with or without amiodarone medication were included whose blood samples were collected and tested in VKORC1 and CYP2C9 genotypes and whose clinical data were collected. The clinical characterics, warfarin medication related data were compared between the groups with and without amiodarone therapy and the genotype status were used in the following subgroup analysis. RESULTS: There are no statistically difference of warfarin dosage or INR(international ratio of PT) value between the groups with and without amiodarone medication and no statistically difference in the following analysis of genotype subgroup. CONCLUSION: The patients on short-duration usage of amiodarone has no obviously effect on warfarin stable dosage and INR value during stable dosage.
2.Determinations of symptomatical fractured vertebrae in treating osteoporotic vertebral compression fractures with vertebroplasty and pitfalls as well as preventive strategy
Hong LIU ; De WANG ; Huiming ZHI
Orthopedic Journal of China 2006;0(18):-
[Objective]Osteoporotic vertebral compression fractures(OVCFs)are commonly multiple fractures and this study is aimed to explore how to determine the symptomatical fractured vertebrae as well as the pitfalls in treating OVCFs using percutaneous vertebroplasty(PVP).[Method]Forty-eight OVCFs patients(78 vertebrae)undergoing PVP were retrospectively analyzed.All the patients had anteroposterior and lateral plain X-rays as well as T1W1,T2W1 and fat-compressing(STIR)MR images preoperatively.The symptomatical fractured vertebrae were determined with combination of regional pain、X-rays and MR images.Of all the patients,36 were injected unilaterally while 12 were injected bilaterally.The mean injected volume of PMMA were 3-7 ml.[Result]The back pain of all the patients were relieved to different degrees postoperatively.The back pain completely disappeared in 30 patients while the left back pain was not improved though the right back pain disappeared in 2 patients who were injected via right approach.The back pain almost disappeared but the bilateral rib pain was not improved in 1 patient with T8 vertebral fracture.No severe complications including pulmonary emboli occurred.[Conclusion]The symptomatical fractured vertebrae should be determined comprehensively not only based on preoperative X-rays but also on the MR images,especially fat-compressing MR images.Only when the fractured vertebrae demonstrate low intensity on T1W1 MR image and high-intensity on T2W1 or fat-compressing MR image can we consider them new fractures.Otherwhise,the fractured vertebrae are considered old fractures and they see no necessity to be injected.The injection should reach the most severely fractured part and if necessary the bilateral approaches are considered.PMMA should be injected after the bone cements are solid enough so as not to develop complications such as pulmonary emboli.
3.Extracorporeal shock wave therapy for chronic pelvic pain syndrome: an update.
Qi GUO ; Mei HONG ; Zhi-Ping WANG
National Journal of Andrology 2014;20(8):747-750
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disease in males, which is characterized by persistent discomfort or pain in the pelvic region. As currently used drug therapies fail to produce satisfactory results, it is an urgent task to find new and effective methods for the treatment of CP/CPPS. In recent years, many reports are seen on the extracorporeal shock wave therapy (ESWT) for CP/CPPS. ESWT can significantly improve the symptoms of pelvic pain and urination disorders in CPPS patients, and its therapeutic effect is attributed to the improvement of angiogenesis and block of pain nerves.
Chronic Pain
;
therapy
;
High-Energy Shock Waves
;
therapeutic use
;
Humans
;
Male
;
Pelvic Pain
;
therapy
;
Prostatitis
;
therapy
4.Change of metabolism of serum lipids in patients with mild cognitive impairment
hong-lian, ZHU ; zhi-hong, PAN ; gen-fa, WANG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(05):-
Objective To study the change of metabolism of serum lipids in patients with mild cognitive impairment(MCI). Methods The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL) and high density lipoprotein(HDL) were measured in 60 patients with MCI and 100 age-matched normal controls. ResultsThe serum levels of TC,TG and LDL were significantly higher and HDL significantly lower in patients with MCI than in normal controls(P
5.Serum cytokine levels in children with febrile convulsion.
Hong-Xia YUAN ; Man-Zhi WANG ; Fang WANG
Chinese Journal of Contemporary Pediatrics 2008;10(3):405-406
Adolescent
;
Child
;
Child, Preschool
;
Cytokines
;
blood
;
Female
;
Humans
;
Infant
;
Interleukin-6
;
blood
;
Interleukin-8
;
blood
;
Male
;
Seizures, Febrile
;
immunology
;
Tumor Necrosis Factor-alpha
;
blood
6.Bilateral laryngeal granulomas after endotracheal intubation.
Zhi-hong LIN ; Hua-lin WANG ; Hui-e WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(1):67-68
Adult
;
Aged
;
Female
;
Granuloma, Laryngeal
;
etiology
;
Humans
;
Intubation, Intratracheal
;
adverse effects
;
Male
10.Feasibility of different xenogeneic (porcine) acellular dermal matrices in the repair of deep burn wounds:a 12-month follow-up
Ming ZENG ; Dinan WEI ; Yan ZHI ; Hong WANG ; Zonghua CHEN
Chinese Journal of Tissue Engineering Research 2016;20(11):1551-1557
BACKGROUND:Skin grafting is crucial for patients with deep burns, but limited source of autologous skin grafts is an existing difficulty.
OBJECTIVE:To investigate the effect of xenogeneic (porcine) acelular dermal matrix in the treatment of deep burn wounds and the feasibility of its application.
METHODS:Forty-one patients with deep burn were divided into two groups according to the intention of the patients, 21 cases in control group and 20 cases in observational group, folowed by autologous split-thickness skin grafting alone or combined with different (porcine) acelular dermal matrix, respectively. After 12 months of folow-up, the graft success rate at postoperative 1, 2, 3, 4 weeks and skin graft contraction rate and wound repair at postoperative 3, 6, 9, 12 months were observed and compared between two groups. Moreover, levels of inflammatory factors were detected and compared between two groups at postoperative 1, 2, 3 months.
RESULTS AND CONCLUSION: The skin graft success rates showed no difference between two groups at postoperative 1, 2, 3, 4 weeks (P > 0.05). The skin graft contraction rates also showed no difference between two groups at postoperative 3, 6, 9, 12 months (P > 0.05). After 12 months of folow-up, no serious scar hyperplasia, but soft texture appeared in the control group. In the observational group, three cases presented with local pigmentation at the early stage, but it gradualy subsided with time; no obvious scar, but only smal, point-like scar, was visible, and the repaired wound exhibited soft touch. No adverse events and death occurred in both two groups. Experimental results show that the treatment of deep burns with autologous split-thickness skin grafting combined with xenogeneic (porcine) acelular dermal matrix is safe and effective, which can improve the quality of wound healing.