Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.

Fracture Fixation ; methods ; trends ; Fractures, Bone ; surgery ; Humans ; Pelvic Bones ; injuries ; surgery

China ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health ; legislation & jurisprudence ; Occupational Health Services ; organization & administration ; standards

Objective To compare the clinical effect of three Endobutton plates and clavicular hook plate in treatment of acromioclavicular joint dislocation.Methods Forty-two patients with acromioclavicular joint dislocation were randomly divided into EB group (20 patients) who were treated with three Endobutton plates and CH group (22 patients) who were treated with clavicular hook plate from January 2008 to January 2011.Perioperative index (operation time,blood loss and VAS scores on the third day postoperatively),Karlsson shoulder joint function scores and postoperative complication were compared.Results The operation time and blood loss in EB group were significantly higher than those in CH group [(113.6 ± 25.3)minvs.(62.3±17.8)min,(152.7±15.2) mlvs.(93.1±18.9)ml,P＜0.O5].However,therehadno significant difference for VAS scores on the third day postoperatively between two groups (P ＞ 0.05).EB group was superior to CH group for shoulder joint function scores on the twelfth month postoperatively,but there had no significant difference [95.0％ (19/20) vs.81.8％ (18/22),P ＞ 0.05].The incidence rate of shoulder joint pain and stiffness in EB group were significant lower than those in CH group[20.0 ％ (4/20) vs.50.0％(11/22),20.0％(4/20) vs.54.5％(12/22),P ＜ 0.05].The incidence rate of incision infection in two groups had no significant difference (P ＞ 0.05).Conclusions Compared with clavicular hook plate,three Endobutton plates fixation is complex and consequently with more blood loss.However,three Endobutton plates fixation have advantage in clinical effect and complication.

Diabetic retinopathy (DR) is the leading causes of blindness in working-aged people,of which diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the two main causes of vision-threatening.Through the regular screening of patients with diabetes,the risk factors of DR can be identified and proper interventions can prevent the incidence of DR.Timely retinal laser photocoagulation and application of the renin-angiotensin system inhibitors (candesartan or fibrates),lipid-lowering drug fenofibrate can inhibit DR progress.Macula local and (or) grid pattern photocoagulation or in combination with bevacizumab intravitreal injection can effectively relief DME.In regard to late PDR,vitrectomy couldrestore or retain useful vision, importantly, minimally invasive 23G vitrectomy and preoperative bevacizumab intravitreal injection greatly improved the surgical outcomes.However DR pathogenesis is not entirely clear.Also there is a lack of effective and feasible DR screening strategy in China.Furthermore existing evidence-based data of medical and surgical treatment of DR is insufficient.Therefore,the DR prevention and treatment is still a long way to go in China.

The clinical application of POCT technology is growing wider,the most significant advantage of this technology is to get the test results quickly,Therefore clinicians could make clinical decisions in time and choose appropriate approaches or interventions.However,it should be taken seriously that while POCT helps patients to get medical care successfully,the potential harm to the patients cannot be ignored.Hence it is essential that normative documents should be imposed as soon as possible.The technology of POCT can benefit the entire society only if the proper administration to approve the use of POCT technology is taken control of; the comprehensive and normative quality management is implemented,and the appropriate training to the related clinicians and nurses is enforced.

Mycoplasma pneumoniae(MP) is a common pathogen of community-acquired pneumonia in children.In recent years,with increase in the incidence of MP infection,the severe cases caused by the later pathogen are also incresing.At present the pathogenesis of severe Mycoplasma pneumoniae pneumonia(SMPP) is still not very explicit,and increased macrolide resistance of MP made a great impact on the treatment.This article reviewed the recent progress in the study of the pathogenesis,clinical manifestations,diagnosis and treatment of SMPP.

Objective To explore the feasibility of conservative treatment in patients with ectopic pregnancy.Methods The clinical data of 38 cases of ectopic pregnancy treated with conservative treatment were retrospectively analyzed.Results All the 38 patients with ectopic pregnancies were treated with MTX single dosage.There were 7 patients who failed in the conservative treatment and the rest of which were successfully cured.Conclusion For those early diagnosis and strictly selected ectopic pregnancy patients .conservative drug treatment is safe and effective.

Acute kidney injury(AKI) can lead to remote organ damage.The specific mechanism by which the AKI results in distant organ damage is yet to be determined.In animal models,it has become increasingly clear that AKI is not an isolated event but results in remote organ dysfunction involving the heart,lungs,liver,and brain.This review summarizes the effects of AKI on remote organs.

Objective To compare the clinical value of automatic coagulometer and automatic biochemistry analyzer for the de-tection of antithrombin Ⅲ(AT-Ⅲ)in acute myocardial infarction and cirrhosis.Methods 55 cases of acute myocardial infarction and cirrhosis patients were investigated in the study,the healthy people was normal control.The concentration of AT-Ⅲwas detec-ted with automatic coagulometer and automatic biochemistry analyzer at the same time.Results The concentration of AT-Ⅲ detec-ted with automatic coagulometer was (251.2±58.5 )mg/L,(228.0 ±22.6)mg/L in acute myocardial infarction and cirrhosis pa-tients,the concentration of AT-Ⅲ detected with automatic biochemistry analysis was (255.6±54.3)mg/L,(230.3±23.1)mg/L in acute myocardial infarction and cirrhosis patients,and the concentration of AT-Ⅲwas significantly lower than that in normal control (P <0.05).The concentration of AT-Ⅲ detected with two detection methods in acute myocardial infarction patients was signifi-cantly lower than that in cirrhosis patients(P <0.05).There were significant difference between automatic coagulometer and auto-matic biochemistry analyzer for the detection of antithrombin Ⅲ(AT-Ⅲ).Conclusion The detection of AT-Ⅲ with automatic coag-ulometer and automatic biochemistry analyzer could diagnose and identify acute myocardial infarction and cirrhosis.