Objective To investigate the correlation between high-resolution computed tomograohy(HRCT)features and thera-peutic effect in patient with non-tuberculous mycobacteria pulmonary disease(NTM-PD).Methods A total of 225 NTM-PD patients were divided into curative group and non-curative group according to the efficacy criteria,and the clinical and HRCT features between the two groups were compared.Correlation analysis and logistic regression analysis were used to screen the risk factors for potential poor efficacy,and their predictive value was evaluated by the receiver operating characteristic(ROC)curve.Results The proportion of cavities,the number of nodules and bronchiectasis involving lung lobes in the non-curative group were significantly higher than those in the curative group,while the body mass index(BMI)was significantly lower than that in the curative group.The distribution of non-tuberculous mycobacteria(NTM)strains,cavities,the number of nodules involving lung lobes,and the number of bronchiecta-sis involving lung lobes were positively correlated with poor efficacy,while BMI was negatively correlated with poor efficacy(P＜0.05).The distribution of NTM strains,the number of nodules and bronchiectasis involving lung lobes were independent risk factors for poor efficacy(P＜0.05).Cavities,the number of nodules involving lung lobes,and the number of bronchiectasis involving lung lobes alone or in combination had high efficacy in predicting poor efficacy,with the highest prediction value of the three combined model[area under the curve(AUC)=0.819;95％confidence interval(CI)0.762-0.876].Conclusion The combined model based on cavities,the number of nodules involving lung lobes,and the number of bronchiectasis involving lung lobes has the highest effi-ciency in predicting poor efficacy in NTM-PD patients.