Objective:To explore the relationship between work connectivity behavior after-hours, self-regulatory fatigue and work engagement of nurses, so as to provide reference for developing strategies to improve nurses′work engagement.Methods:This was a cross-sectional survey study. A total of 661 nurses from 10 hospitals in Shandong Province were selected as subjects by convenience sampling method from June to August 2022. The Work Connectivity Behavior After-hours Scale, Self-Regulatory Fatigue Scale and Work Engagement Scale were used to measure the work connectivity behavior after-hours, self-regulatory fatigue level and work engagement level. A structural equation model was constructed to evaluate the mediating effect of self-regulatory fatigue on work connectivity behavior after-hours and work engagement.Results:The scores of work connectivity behavior after-hours, self-regulatory fatigue and work engagement of nurses were (37.66 ± 7.05), (42.98 ± 10.55) and (34.29 ± 6.58) points, respectively. The total effect of work connectivity behavior after hours on work engagement was -0.336 6. The work connectivity behavior after-hours was positively correlated with self-regulatory fatigue ( r = 0.423, P<0.01) and work engagement was negatively correlated with work connectivity behavior after-hours and self-regulatory fatigue ( r = -0.361, -0.479, both P<0.01). Self-regulatory fatigue had a partial mediating effect on work connectivity behavior after-hours and work engagement, accounting for 46.61% of the total effect. Conclusions:Self-regulatory fatigue has a mediating effect on the relationship between nurses′ work connectivity behavior after-hours and work engagement. Nursing managers should reduce the degree of self-regulatory fatigue of nurses by preventing their work connectivity behavior after-hours, so as to improve the work involvement level of nurses.

AIM : To investigate the effects of Ca 2+ /CaM dependent calcineurin(CaN) signaling pathway on cardiomyocytes hypertrophy of rat induced by neuropeptide Y(NPY). METHODS : Cardiomyocytes of neonatal Wistar rats were cultured with NPY of various concentrations (10,100 nmol?L -1 ). Cyclosporine A (CsA) was used to inhibit the activity of CaN. The methods of 3H Leu incorporation was used to assess protein synthesis rate in cardiomyocytes. Western blot and histochemistry were used to measure CaN protein expression and CaN activity in cardiomyocytes. RESULTS : 3 H Leu incorporation of cardiomyocytes were increased significantly by 100 nmol?L -1 NPY ( P

Objective:To investigate the values of ultrasound elasticity(UE)imaging and color Doppler flow energy(CDFI)in differential diagnosis for triple negative breast cancer(TNBC)and fibroadenoma.Methods:A total of 50 TNBC patients who admitted to People's Hospital of Wanning from January 2021 to January 2022 and were confirmed by surgical pathology were selected,and they were divided into TNBC group.On the other hand,a total of 50 patients with fibroadenoma who were confirmed by surgical pathology during the same period were selected and they were divided into fibroadenoma group.All patients did not undergo any clinical intervention before ultrasound examination.UE and CDFI were used respectively to evaluate the degrees of softness and hardness of the tissues,the color blood flow and elasticity scores of lesions.The pathological result was used as the gold standard to analyze respectively the diagnostic efficacies of UE and CDFI for TNBC and fibroadenoma.Results:According to the characteristics of ultrasound imaging,the TNBC group mostly showed burr sign on lesion edge,the attenuation and hyperechoic halo of posterior echo,and existing axillary lymph node metastasis.The fibroadenoma group mostly showed clear boundaries of lesion area,regular lesion morphology,non-microcalcification.The diagnostic sensitivity,specificity and accuracy of UE detection were respectively 90.91%,82.14%and 86.00%,while these indicators of CDFI were respectively 73.08%,75.00%and 74.00%.In addition,the sensitivity,specificity and accuracy of the combined detection of them were respectively 94.23%,95.83%and 96.00%.The detection efficiency of the combined detection was higher than that of each single detection.Conclusion:UE has higher sensitivity in the differential diagnosis of TNBC and fibroadenoma,but it's specificity is not high.The combined detection of UE and CDFI can improve the specificity and accuracy of differential diagnosis.