1.Clinicopathological characteristics and prognostic factors of gastric neuroendocrine neoplasms: an analysis of 117 cases
Chao WANG ; Jingyi ZHANG ; Zhenxia ZHANG ; Lin SUN ; Yuhong GUO ; Bing SHAO ; Shuai ZHAO ; Yan SUN
Chinese Journal of Clinical Oncology 2019;46(5):239-246
Objective: To explore the clinicopathological characteristics and prognostic factors of gastric neuroendocrine neoplasm (NEN). Methods: Clinicopathological parameters and follow-up data collected from 117 patients with gastric NEN at Tianjin Medical University Cancer Institute and Hospital from March 2011 to December 2017 were reviewed, classified, and graded according to World Health Or-ganization (WHO) 2010 classification. Clinicopathological characteristics of different types and grades of gastric NEN were compared and survival analysis was performed. Results: Among the 117 cases confirmed as gastric NEN, this entire cohort comprised 13 cases (11.1%) of neuroendocrine tumor (NET) G1, 6 cases (5.1%) of NET G2, 57 cases (48.7%) of neuroendocrine carcinoma (NEC), and 41 cases (35.1%) of mixed adenoneuroendocrine carcinoma (MANEC). Gastric NET G1 and G2 typically consisted of multiple small tumors with shallow invasion and infrequent lymphatic and distant metastases at early stages at the time of diagnosis. The treatment of patients with gastric NET included endoscopic submucosal dissection and radical surgical resection. Precursor neuroendocrine lesions were detected in most cases. The patients with gastric NET G1 and G2 had a good prognosis. Gastric NEC and MANEC mostly consisted of single large tumors with deep infiltration, and common lymphatic and distant metastases at advanced stages when the diagnoses were confirmed. All the patients with gastric NEC and MANEC underwent surgical resection, and most received adjuvant therapy. Histopathological changes of gastric NEC were characterized by large cells and poorly differentiated tumors, while gastric MANEC had various forms of neuroendocrine and adenocarcinoma components. The prognosis of patients with gastric NEC and MANEC was poor for both; however, the predictors of progression-free survival and overall survival were different between gastric NEC and MANEC. Conclusions: Gastric NEN are a group of heterogeneous tumors with different clinicopathological features and prognosis. More multicenter studies with large sample sizes are still needed to improve the classification of gastric NEN and explore the prognostic factors.
2.Research progress in trauma registration system
Zhenxia GUO ; Shiyao WANG ; Yatao LIU ; Xingwen HAN ; Wenji WANG ; Pei CHU ; Yongwei LIU ; Xiang LI ; Michael NERLICH ; Wenjin WANG ; Liping LIU
Chinese Journal of Trauma 2022;38(4):374-379
Trauma registration is an important tool to record the process and timeline in the treatment of trauma patients. The operation of trauma database is of great significance for reducing the mortality of patients, promoting the construction of trauma treatment system, and providing reference for policy-making. Trauma registration system has been established in the United States, United Kingdom, Germany and other developed countries for many years. However, the domestic system is still at an initial stage, and there are problems like data deficiencies, data incoherence, no item of complications, no treatment data after discharge and limits of human and financial resources. Therefore, there is room for improvements in terms of personnel fixation, financial support and continuous data monitoring should be further improved. In this study, the authors summarize the traum registration system from aspects of basic situation both at home and abroad, data analysis, clinical value, operation mechanism and challenges so as to provide important data for clinical researches.
3.Research Progress on Resources of Blumea balsamifera
Xiaoli XIE ; Zhenxia CHEN ; Yuxin PANG ; LingLiang GUAN ; KaiMian GUO
World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(12):2024-2029
Blumea balsamifera resource is an important material foundation for the breeding,quality identification,genetic research,biotechnology research and agricultural production.It is also the material basis for sustainable development of Blumea balsamifera.In this paper,we reviewed the related research on Blumea balsamifera resources in China,and discussed existing problems of Blumea balsamifera resources,and put forward some suggestions on key research direction in the future,for peer reference and discussion in use and further study promotion of Blumea balsamifera resources.