Objective:To explore the feasibility of sustained-release ibuprofen gel as a new local drug and its efficacy in the treatment of chronic periodontitis.Methods:Sustained-release ibuprofen gel was manufactured with PLGA as sustained-release adjuvant.Its release in vitro was tested by UV-spectrophotometer.60 teeth from 30 chronic periodontitis patients were chosen.Each patient had two teeth which were similar.The two teeth of every patient were divided into experiment group and control group.After scaling and root planning the sustained-release ibuprofen gel was injected into the pocket in the experiment group every week,two times in all.While those in the control group only had scaling and root planning.The local symptoms,sulcus bleeding index(SBI),probing depth(PD) and attachment level(AL) of the two groups were observed in the second and fourth week after treatment.Results obtained from the two groups were compared.Results:There were significant differences in each clinical index between the experiment group and the control group(P

Objective:To study the efficacy and safety of CT guided percutaneous transhepatic microwave ablation (PTPMWA) for primary liver cancer (PLC) in liver segment 9.Methods:A retrospective study was conducted on PLC patients between October 2013 and March 2019 at Dongguan People’s Hospital, Southern Medical University. Of 41 patients who entered into the study, there were 36 males and 5 females, with an average age of 59.1 years. These patients were diagnosed to have PLC in segment 9. The surgical related data and follow-up results were collected and analyzed.Results:All patients enrolled in the study completed the treatment procedure. CT scan was performed immediately after ablation which showed that the tumor areas to be completely covered by ablation. The duration of operation ranged from 45 to 260 (mean 91) min. The amount of bleeding during treatment was 1.0 to 5.0 (mean 1.4) ml. The complete response rate was 97.6% (40 patients) and the partial response rate was 2.4% (1 patient). The cumulative survival rates at 1, 2, 3, 4 and 5 years were 95.1%, 85.4%, 75.3%, 45.2% and 45.2%, respectively. Only 4 patients (9.8%) developed recurrence after treatment. The timings of recurrence were 1, 6, 13 and 67 months after treatment, respectively. The recurrent lesions were ablated again and complete response was obtained in all patients. There were no serious problems related to complications from ablation. The rate of postoperative complication was 7.3% (3 patients).Conclusion:PTPMWA is a novel treatment for patients with PLC in liver segment 9, the advantages of this treatment include good safety, high efficacy, low complications and local recurrence. The treatment is worthy of further future studies.