1.Mechanism of Cerebral Blood Flow of Sustained Attention Dysfunction in Patients with Attention-deficit Hyperactivity Disorder
Huanjing LI ; Bin GENG ; Shuang WANG ; Zengshan LIU ; Daguang ZHANG ; Zhenwang LIU ; Qing ZHANG
Chinese Journal of Medical Imaging 2017;25(3):190-195
Purpose Sustained attention dysfunction is a common symptom of patient with attention-deficit/hyperactivity disorder (ADHD).To reveal the neural mechanism of the abnormality of sustained attention of patients with ADHD,the cerebral blood flow (CBF) abnormalities in patients were studied by perfusion imaging.Materials and Methods Sixteen children with ADHD and twenty normal controls treated at the 401st Hospital of PLA from June 2013 to September 2015 underwent 3D arterial spin labeling (3D-ASL)scanning with GE 3.0T MRI scanner.The participants were performed four continuous sections of sustained attention to response task (SART) for 20 minutes in the scanner.Using SPM 8 toolkit,the local CBF values of both groups were compared in a voxel-wise manner,and their correlations with response time and target accuracy of SART were analyzed.Results When performing the SART,the patients with ADHD showed significantly inhibited trend of increasing CBF in the anterior cortex like dorsal cortex,medial prefrontal cortex,and motor area;however,they presented enhanced trend of increasing CBF in the posterior cortex such as posterior cingulate cortex and parietooccipital sulcus (P<0.01);the change of CBF in the dorsal prefrontal cortex and that in the precentral and postcentral gyrus had significant correlation with response time of SART task and targeting ratio (dorsal prefrontal cortex:r=0.745,P<0.001;r=0.591,P<0.001;r=-0.521,P<0.001.Precentral and postcentral gyrus:r=0.579,P<0.001).Conclusion Patients with ADHD show different CBF redistribution between anterior and posterior cerebral cortex in performing SART,and the abnormal CBF shows significant correlations with behavioral metrics,which reflects the mechanism of sustained attention dysfunction of patients with ADHD.
2.Progress of study in auditory event-related potentials of novel events.
Boqiang LIU ; Zhenwang ZHANG ; Zhongguo LIU ; Mingshi WANG ; Qiang ZHU
Journal of Biomedical Engineering 2007;24(3):705-708
This is a review of the progress in the study on auditory event-related potentials (ERP) of novel events. Several cognitive problems about the novelty ERP response on brain and the experiment methods are introduced. The mismatch negative potential (MMN) reflects the detection of deviant events, and MMN is related with the novelty P3. Familiarity and attention influence the novelty ERP response. Experiments results showed that the amplitude of ERPs in the frontal area was reduced with the enhancement of familiarity, while that in the parietal area had little change. Attention was helpful in increasing the amplitude of ERPs, and could make the corresponding brain area active. The functional significance of the response of ERP was discussed also.
Auditory Perception
;
physiology
;
Brain
;
physiology
;
Electroencephalography
;
Environment
;
Event-Related Potentials, P300
;
physiology
;
Evoked Potentials, Auditory
;
physiology
;
Humans
3. Prevalence and antimicrobial susceptibility of Salmonella isolated from broiler whole production process in four provinces of China
Weiwei LI ; Li BAI ; Xiuli ZHANG ; Xiaojie XU ; Zhen TANG ; Zhenwang BI ; Yunchang GUO
Chinese Journal of Preventive Medicine 2018;52(4):352-357
Objective:
To determine the prevalence and antimicrobial susceptibility of Salmonella isolated from broiler production process in 4 provinces of China.
Methods:
Using convenience sampling method, 238 sample sites from broiler whole production process were chosen in Henan, Jiangsu, Heilongjiang and Shandong provinces in 2012. A total of 11 592 samples were collected and detected to analyze prevalence baseline, including 2 090 samples from breeding chicken farms and hatcheries, 1 421 samples from broiler farms, 5 610 samples from slaughterhouses and 2 471 samples from distribution and retail stores. All
4.Spatial and temporal characteristics of human brucellosis, from 2004 to 2012 in Shandong province
Li YANG ; Zengqiang KOU ; Zhenwang BI ; Luyan ZHANG ; Li ZHENG ; Zhongtang ZHAO
Chinese Journal of Epidemiology 2014;35(8):925-929
Objective To explore the spatial and temporal characteristics of human brucellosis in Shandong province and to provide scientific basis for the development of related regional public health strategies.Methods 1 802 diagnosed cases of human brucellosis patients were selected based on the data that was collected by Diseases Reporting Information System between year 2004 and 2012 in Shandong province.Methods on spatial thematic mapping,spatial autocorrelation analysis,spatial clustering analysis,and temporal clustering analysis were applied to describe the temporal and spatial distribution on human brucellosis cases.Results The incidence rate of human brucellosis increased from 0.038 2/100 000 (35 cases) to 0.620 5/100 000 (598 cases),with annual average incidence rate as 0.211 1/100 000 and the incidence was evidently increased.The value of M (0.375 3) showed that this disease was seasonal,with the epidemic months between March and June,accounting for 56.27% (1 014/1 802).The Global Moran' s I index was 0.198 901 (P=0.000 120),showing that there was a positive correlation between space and the incidence of brucellosis.The incidence rates in 2006,2007,2009 and 2012 and the space distribution appeared a positive correlation (P<0.05) in Shandong province.The local Moran's I index showed that there were 8 “High-High” (HH) clustering areas,which were proved to have statistical significance (P<0.05).Local indicators of spatial association (LISA) revealed that southwest and north districts of Shandong were highly clustered districts of brucellosis and the areas paralleled to the areas that having higher incidence rates.There were two spatial clustering areas in this study,one as the center of Juanchen with radiation radius at 33.83 km whose RR was 9.78 (P<0.05) and the other was the center of Binchen with radiation radius at 62.78 km with RR as 4.99 (P<0.05).All the 8 HH counties (districts) were included in the two cluster regions.Conclusion Incidence of human brucellosis showed an obvious increase in Shandong during year 2004-2012.Months with epidemics were between March and June.The incidence of brucellosis in counties (districts) was non-randomly distributed.A positive spatial correlation and the feature of clusters was noticed.
6. Etiology and epidemiological characteristics of gastroenteritis virus in food-borne diarrhea from three cities in Shandong Province, 2017
Wenqiang ZHANG ; Huaning ZHANG ; Yang HAN ; Xinpeng LI ; Xiaolin LIU ; Zhongyan FU ; Zhenwang BI ; Aiqiang XU ; Haiyan WANG
Chinese Journal of Preventive Medicine 2020;54(2):169-174
Objective:
To analyze the etiology and epidemiological characteristics of gastroenteritis virus in foodborne diseases from three cities in Shandong.
Methods:
From January to December 2017, six sentinel hospitals in Jinan, Yantai and Linyi city of Shandong Province were selected as the research sites. Stool samples of 1 397 diarrhea patients were collected, as well as basic information and clinical symptoms. Duplex quantitative RT-PCR was used to detect Norovirus genogroupⅠ (Nov GⅠ) and genogroupⅡ (Nov GⅡ), Sapovirus (SAV) and Human astrovirus (HAstV), respectively, quantitative RT-PCR was used to detect group A Rotavirus (RVA), and quantitative PCR was used to detect Enteric adenovirus (EAdV). The specific gene of the virus were sequenced and typed. It was compared that the gastroenteritis virus rate in cases with different characteristics and the clinical symptoms difference between the virus positive and negative cases.
Results:
The median age (
7.Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011.
Jikai LIU ; Li BAI ; Weiwei LI ; Haihong HAN ; Ping FU ; Xiaochen MA ; Zhenwang BI ; Xiaorong YANG ; Xiuli ZHANG ; Shiqi ZHEN ; Xiaoling DENG ; Xiumei LIU ; Yunchang GUO
Frontiers of Medicine 2018;12(1):48-57
Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differences in the patterns of pathogens detected with diverse characteristics. Vibrio parahaemolyticus has been the leading cause of infectious diarrhea in China, especially among adults in coastal regions. Salmonella has been a serious and widely distributed pathogen responsible for substantial socioeconomic burden. Shigella was mostly identified in Northwest China and the inland province (Henan) with less-developed regions among children under 5 years. Data from foodborne disease outbreak reporting system from 2011 to 2016 showed that poisonous animals and plant factors responsible for most deaths were poisonous mushrooms (54.7%) in remote districts in southwest regions. The biological hazard that caused most cases reported (42.3%) was attributed to V. parahaemolyticus, the leading cause of foodborne outbreaks. In this review, we summarize the recent monitoring approach to foodborne diseases in China and compare the results with those in developed countries.
Bacteria
;
classification
;
isolation & purification
;
China
;
epidemiology
;
Disease Outbreaks
;
Food Microbiology
;
Foodborne Diseases
;
epidemiology
;
microbiology
;
Forecasting
;
Humans
;
Laboratories
;
Mushroom Poisoning
;
epidemiology
;
Population Surveillance
;
Public Health