In this article,the author systematically summarized professor SUN Gui-zhi' academic thoughts about pathogeny and treatment of tumour.Professor SUN Gui-zhi thinks that the Phlegm is one of the most important pathogenic evils that induce tumour.As to cold and heat syndrome of tumour,she thinks that heat syndrome is more important.While to defi ciency and excess syndrome,she thinks excess syndrome primary in the early time,deficiency-excess in complexity in intermediate stage,and defi ciency syndrome primary in later period of tumour.In treatment of tumour,professor SUN Gui-zhi pays more attention to dispelling pathogenic evils of phlegm and heat,at the same time protecting stomach qi,and adjusting the helm opening and closing of qi movement.She is good at making complex and large prescription.

The etiology of uveitis is very complicated and the pathogenesis is not yet clear.In recent years,more and more evidences imply that the chemokines interleukin-8 (IL-8) is involved in the development of uveitis.Studies of IL-8 and its network features contribute to the understanding of uveitis pathogenesis and provide an important foundation for seeking new indication of activity of uveitis and new treatment target.This paper summarizes the progression in the study on IL-8 in uveitis,including the physiology functions of IL-8,mechanisms for ocular inflammatory,and the role and performance of IL-8 in uveitis.

Most colorectal cancers develop from adenomas. Environmental factors play an important role in the development and progression of adenoma. Recently,epidemiologic investigations on lifestyle change including diet and exercise and drug intervention studies have proved the relationship between environmental factors and colorectal cancer. Screening,polypectomy and surveillance via colonoscopy are the main measures of colorectal cancer prevention. However, the efficacy is unsatisfactory. Therefore,attention should be paid to studies on colorectal cancer prophylaxis via intervention on environmental factors. Emphasis should be put on various aspects of environmental intervention in clinical practice,and prophylaxis strategies should be generated individually in accordance with the local condition and situation.

Pulmonary arterial hypertension ( PAH) is a progressive lethal vascular disease, which is characterized by pulmo-nary vasoconstriction and vascular remodeling. Recent studies have indicated that the metabolic theory, centered on the loss of mito-chondrial function, plays a key role in the occurrence and development of PAH. This theory links mitochondrial-related changes of ap-optosis-resistance, glycolysis enhancement, mROS decrease and aberrant mitochondrial dynamics to multiple molecular abnormalities, which may provide new ideas for exploring more comprehensive and specific treatment strategies. This article reviews the progresses in mitochondrial abnormality in PAH.

Objective The separation of various proteins in urine was used to differentiate the types of urinary protein to determine the site of diabetic kidney damage and lesions.Methods We used sodium dodecyl sulfonate-agarosegel electrophoresis(SDS-AGE) to detect the unconcentrated urine on 108 cases patients with diabetic nephropathy urine specimens analysis.Results The results of urinary protein electrophoretic of 108 patients displayed: 4 cases for renal tubular proteinuria,10 cases for physiological proteinuria,22 cases for glomerular proteinuria,72 cases for mixed proteinuria.Conclusion Urine protein electrophoresis for diabetic nephropathy patients with positive can distinguish the various components,and to understand the degree of kidney damage and lesions.This method is low-cost,non-invasive and highly sensitive.The film can be stored.It is worthy to be popularized.

Matrix metalloproteinases(MMP) are a family of Zn~(2+)-dependent endopeptidases capable of cleaving components of extracellular matrix(ECM).MMP-1 was the first vertebrate collagenase purified as a protein and cloned as a cDNA,and is considered the prototype for all the interstitial collagenases.It is synthesized as a zymogen.Its N-terminal residues are removed by proteolysis and it shares with other MMPs a catalytic domain and a carboxy terminal domain with the sequence similar to hemopexin.(MMP-1) should be considered as a multifunctional molecule since it participates not only in the turnover of collagen fibrils in the extracellular space but also in the cleavage of a number of nonmatrix substrates and cell surface molecules,suggesting an important role in the regulation of cellular behaviour.Furthermore,an extensive body of evidence indicates that MMP-1 plays an important role in diverse physiologic processes such as growth,tissue morphogenesis,and wound repair.Likewise,it seems to be implicated in a variety of human diseases including atherosclerosis,rheumatoid arthritis,pulmonary emphysema,and fibrotic disorders,suggesting that its inhibition or stimulation may open therapeutic avenues.

[Objective] To provide a basis for the identification of six species of Calicarpa. [Methods] Histological and microhistological features were studied. [Results] Obvious distinctive features of color and types of villi on the back of the leaf were found. [Conclusion] The method can be used to distinguish the features of the six species of Calicarpa.

Aim To investigate the effects of bradykinin on the expression of IL-1? in C6 glioma cells and provide an experimental basis for the mechanism of bradykinin opening the blood tumor barrier.Methods Semi-quantitive RT-PCR and radioimmunoassay were used to detect the expression of IL-1?mRNA in C6 glioma cells and the content of IL-1? in the culture media treated with bradykinin respectively.Results RT-PCR revealed that the expression of IL-1?mRNA was significantly elevated with bradykinin treated for 15min(P

Objective The separation of various proteins in urine was used to differentiate the types of urinary protein to determine the site of diabetic kidney damage and lesions. Methods We used sodium dodeeyl sulfonate - agarosegel electrophoresis(SDS - AGE) to detect the unconccntrated urine on 108 cases patients with diabetic nephropathy urine specimens analysis. Results The results of urinary protein electrophoretic of 108 patients displayed: 4 eases for renal tubular proteinuria, 10 eases for physiological proteinuria, 22 eases for glomerular proteinuria, 72 cases for mixed proteinuria. Conclusion Urine protein electrophoresis for diabetic nephropathy patients with positive can distinguish the various components, and to understand the degree of kidney damage and lesions. This method is low -cost, non - invasive and highly sensitive. The film can be stored. It is worthy to be popularized.

Objective To investigate the effects of inhalation of different concentrations of nitrous oxide on intracuff pressure (ICP) of the laryngeal mask airway (LMA) in patients during general anesthesia. Methods Forty-right ASA Ⅰ or Ⅱ patients aged 25-64 yr undergoing elective operations under general anesthesia were randomly divided into 4 groups (n=12 each): group C (100 %O2, group N2 (65 % O2 + 35%N2O), group N2 (50%O2 + 50 % N2O), and group N3 (35%O2 + 65%N2O). A suitable model of the LMA was selected according to height and weight. Anesthesia was induced with Ⅳ propofol 1.5-2.0 mg/kg, fentanyl 2-3 μg/kg, lidocaine 1-2 mg/kg and vecuronium 0.08-0.1 mg/kg and maintained with intravenous infusion of propofol and intermittent boluses of fentanyl and vecuronium. After the successful placement of LMA, the air was injected into the cuff to make intracuff pressure (ICP) reach 40 cm H2O (baseline). The ICP were recorded at 15, 30, 45, 60, 75 and 90 min (T1-6) following inhalation of N2O. Results The ICP grandually increased with the increase in the concentration of N2O (P<0.05). The ICP decreased at T2-6 in group C, but increased at T2-6 in group N1 and at T1-6 in group N2,3 as compared with baseline(P<0.05). There was a positive correlation between the ICP and inhalation time in group N1-3(r1-3=0.968,0.987,0.973 respectively, P<0.05). Conclusion The inhalation of N2O can increase the ICP in concentration- and time-dependent manners,