Hair follicle stem cells (FSCs), which have characteristics of slow cycling and multipotential differentiations, play an important role in maintaining hair follicle cycling and repairing the epidermis during wound healing. The researches in this subject may be helpful to provide new ideals in treating the diseases of hair and skin. As we know, the Wnt signal transduction pathway has a significant meaning in controlling the proliferation and differentiation of FSCs, and different Wnt proteins have different functions in this process. In this paper, we review how the Wnt signal transduction pathway controls the FSCs and what the functions of different Wnt proteins are.
Cell Differentiation ; drug effects ; Cell Proliferation ; Cells, Cultured ; Hair Follicle ; cytology ; Humans ; Signal Transduction ; Stem Cells ; cytology ; Wnt Proteins ; genetics ; physiology