1.Correlation study of neurologic functional rehabilitation and concentrations of serum and cerebrospinal fluid C-reactive protein in patients with acute cerebral infarction
Journal of Chongqing Medical University 1986;0(04):-
Objective:To evaluate the clinical value of determinations of C-reactive protien concentration in serum and cerebrospinal fluid from patients with acute and recovery cerebral infarction and to find out the correlation of it with neurologic deficits,infarct sige and duration.Methods:46 cases of patients with cerebral infarction were recruited as observe group and 25 cases of healthy examinees or patients undergoing operation of fracture,appendix or cholecyst ectomy were recruited as control group.We measured C-reactive protien in cerebrospinal fluid and serum.Comparison analysis was performed using a SPSS10.0 statistical package.Results:Concentration of C-reactive protien in cerebrospinal fluid and serum was significantly higher in patients with cerebral infarction than that in patients at recovery stage and control group(P
2.Assay of NSE concentration in serum and cerebrospinal fluid of patients with viral encephalitis and its clinical correlation
Journal of Chongqing Medical University 2008;0(S1):-
Objective:To investigate the changes of neuron-specific enolase(NSE)concentration in serum and cerebrospinal fluid from patients with acute and recovery viral encephalitis and to find out its correlation with anomaly electroencephalogram and low density focus volume in imageology. Methods:42 cases of patients with viral encephalitis were enrolled and 25 cases of health examinater or patients with operation of appendix or cholecyst were enrolled in control group.We measured the NSE concentration in cerebrospinal fluid and serum using enzyme-linked immunosorbent assay. Comparison analysis was performed by using a SPSS13.0 statistical package. Results:NSE concentration in serum and cerebrospinal fluid of patients with acute viral encephalitis was significantly higher than that of recoverys and control group(P
3.Clinical Observation on ShenQiFuZheng Injection on Side Effects of Chemotherapy after Colon Cancer Operation
International Journal of Traditional Chinese Medicine 2009;31(5):431-432
Objective To study the effect of ShenQi FuZheng injection on side effects of chemotherapy and the patients' life quality after operation of colon cancer. Methods 60 patients were recruited into a control group and a treatment group, with 30 patients in each group. The treatment group was treated with conventional chemo-medicines plus ShenQi FuZheng injection, while the control group was treated with conventional chemo-medicines exclusively. Side effects and life quality were compared between the two groups after two courses of treatment. Results The side effects and mark of the life quality in the treatment group were both obviously better than the control group (P<0.05) after the treatment. Condusion ShenQi FuZheng injection can decrease side effects of chemotherapy and improve patients' life quality.
4.Experimental study of biological membrane in prevention of adhesion of tendon
Zhenhai WANG ; Huanyu HONG ; Hai WANG
Orthopedic Journal of China 2006;0(21):-
[Objective]To investigate the effect of Zhenghai biological membrane in the prevention of adhesion of tendon. [Method]Eighteen chicken were divided into 2 groups.Zhenghai biological membrane was used in the experimental group,while simple Kessler suture was applied in the control group.The tendon adhesion degrees were compared between 2 groups with the methods of gross observation,adhesion criterion,histological observation and electron microscopy,et al.[Result]The adhesion degree was lower significantly in experimental group than that in control group.[Conclusion]Zhenghai biological membrane could prevent tendon adhesion effectively,without any obvious rejection reaction.It would not affect the healing of the tendon.
5.Experimental study of esophageal metallic stent in rabbits
Zhenhai DI ; Yongzhong WANG ; Xiaochuan WANG
Journal of Interventional Radiology 1994;0(04):-
Objective To analyze the reaction in rabbit's esophagus after inserting metallic nitinal stent and obtaining suggestion for the clinical application.Methods The selfexpanding nitinal stent was placed in each of eight rabbits's esophagus. The rabbits were killed at 2,4,6,8 weeks after implantation. Tissue around the stent was investigated with naked eye and microscopy. Results Chronic inflammation and edema were seen in the submucous tissue 2 week after stenting. Slight stenosis occurred at the regions of two ends of the stent and scattered vegetations like polyp were seen with naked eye at 4 weeks, with inflammatory cell infiltration, partial mucous polypoid hyperplasia under microscopy. The pathological changes were more obvious at 6 weeks comparing with the 4 weeks. The lower end of one stent was embedded in esophageal wall. Two rabbits of 8 weeks' group died of obstruction with food tarried inside the stents.Conclusions The restenosis after stenting were mainly seen at the region of terminals of stent. Thus reformation of stent should be taken place urgently especially at the terminals for the prevention of restenosis.
6.Bursitis around the knee joint: differential diagnosis and treatment
Zhenhai WANG ; Yongcan LIU ; Tiansheng WANG ;
Chinese Journal of Orthopaedic Trauma 2004;0(05):-
Objective To discuss the differential diagnosis and treatment of bursitis around the knee. Methods 32 patients with bursitis around the knee were treated from March 2000 to March 2002 in our hospital. Their diagnosis and treatment were reviewed. The arthroscopy of knee confirmed all the initial diagnosis of the patients made by the physical examination and complaints. We gave them conservative treatment and analyzed the clinical follow ups. Results All the patients were followed up for 8 to 40 weeks. 9 of them who had no internal knee lesions but only one kind of bursitis healed within 3 weeks. 23 of them who had more than two kinds of bursitis (including four who had internal knee lesions) healed within 3 to 5 weeks. Conclusions The differential diagnosis of the bursitis around the knee can be made on the basis of complaints and physical examination. These cases can be managed by conservative treatment.
7.Basic research of the expression and localization of BDV nucleoprotein in oligodendroglial cell
Zhenhai WANG ; Jian LIU ; Peng XIE
Chinese Journal of Microbiology and Immunology 2010;30(9):816-820
Objective To investigate the expression and location of Borna disease virus(BDV)nucleoprotein in transfected oligodendrocytes,and then to explore its expression mechanisms in oligodendroglial cell(OL)and their effects on cell proliferation.Methods We used PCR to detect BDVp40 gene fragments in transfected OL,laser confocal microscopy and Western blot method to detect the expression of nuclear protein and its intracellular location in the cell,MTT to detect the influence of cell proliferation by nuclear protein on the OL.Results We had detected the BDVp40 gene fragments in transfected oligodendrocytes.The nucleoprotein can be positioned in the cytoplasm and cell membrane by laser scanning confocal microscope;Western blot results showed that there is nucleoprotein in the constitutive protein,but was not detected in the cytoplasm.MTT tests showed that nucleoprotein expressed in OL can inhibit cell proliferation.Conclusion It is indicated that the transfected OL stablely express of BDV nucleoprotein,and itslocation is in the cell structure of proteins,particularly in the cytoplasm and more richer in cell membrane,that indicating they may play a key role in cell signal transduction or into the cell-mediated viral infection.BDV nucleoprotein inhibit proliferation of OL,which maybe an important mechanism of Borna disease virus persistant infection and produce symptoms.
8.Wireless real-time monitoring system for body temperature
Hongfu WANG ; Xuesheng LI ; Zhenhai SUN
Chinese Medical Equipment Journal 2004;0(07):-
The wireless real-time monitoring system for body temperature is based on electronic thermometry and wireless communication technology. It can measure and store the patient's body temperature during the desired time span, and can transmit the data to the computer terminal or the cell phone terminal through wireless transmission system.
9.Expression of T-lymphocytes and cytokines in the decidua of mifepristone with misoprostol for terminating early pregnancy
Shiyan LU ; Ruifang WU ; Zhenhai WANG
Chinese Journal of Obstetrics and Gynecology 2000;0(10):-
0 05) Conclusions Mifepristone with misoprostol for terminating early pnegnaney might be affect the expression of lymphocyte and cytokines and induce the disorder of decidual micro environment which might be the reason of medical abortion
10.The clinical experience of interventional embolization in treatment of Graves disease
Zhenhai DI ; Xiaochuan WANG ; Longtu LIU
Journal of Interventional Radiology 1992;0(01):-
Objective To evaluate the method and result of thyroid artery embolization as a new therapy for Graves disease.Methods Ten patients with Graves disease underwent selective thyroid artery embolization. Totally 25 thyroid arteries were embolized with PVA microspheres. The indications to this therapy were as following: Graves disease with recurrent clinical symptoms or with leucopenia during the period of treating with administration of antithyroid drugs or recurrence after subtotal thyroidectomy. Results Serum level of thyroid hormones dropped significantly [median FT 3 from 20.90pmol/L(13.36~50.92pmol/L) to 7.81pmol/L(3.67~35.3pmol/L), median FT 4 from 57.9pmol/L(30.96~57.9pmol/L) to 28.13pmol/L(20.44~39.60pmol/L), ( P