Despite solitary pulmonary nodule (SPN) is a common medical problem in the clinic,the managements can be quite complex.The aetiological agent is largely unknown.Making a definitive diagnosis for SPNs before the operation has been a clinical challenge.A major problem for clinicians and radiologists were to identify the nature of benign and malignant SPNs at an early stage,and let the patients receive therapies timely and effectively.At present,many clinical features and detect methods of SPNs have been applied for differentiating the nodules,but these are not fully to distinguish it.Recently,some progressions had brought qualitative improvements to the diagnosis and treatment of SPNs.Therefore,in this paper,the research status and progresses of SPNs were reviewed.

There is a high incidence of esophageal cancer(EC) in China.The survival and prognosis of EC is unoptimistic due to the lack of efficient early diagnostic markers.There is an urgent demand of novel biomarkers with more stability,sensitivity and specificity.miRNAs are a class of small non-coding single stranded RNAs consisting of 21-23 nucleotides,which are involved in the pathological and physiological process of life activities.miRNAs are stable not only in tumor tissues,but also in serum/plasma.There are significant differences in the expression patterns of circulating miRNAs between two main types of EC.They are closely related to the occurrence and progression of EC,which make circulating miRNAs a novel kind of biomarkers for differential diagnosis,early supervision of esophageal cancer,and prognosis.

OBJECTIVETo explore a new surgical method and its effect in repairing secondary nasal deformity of unilateral cleft lip.

METHODSSixty-two patients with secondary unilateral lip and nasal deformity were treated with asymmetric butterfly incision combined with vestibular V-Y advance flap, and the subjective and objective indicators after operation were observed.

RESULTSAll incisions healed with primary healing and all cases were followed up for 3-12 months. Fifty-eight cases got symmetric nostril and alar, the sum of absolute value of the nostril differences between both sides < 3 mm. Two cases got symmetric nostril and alar, but the sum of absolute value of the nostril differences between both sides was 3.5 mm and 4.2 mm respectively. The alar relapsed again in 2 cases and the results were not satisfied, the sum of absolute value of the nostril differences between both sides > 5 mm.

CONCLUSIONSThe method of using the asymmetric butterfly incision combined with vestibular V-Y mucosa flap can reset the skin,cartilages and mucosa to the anatomic position effectively.

Animals ; Cartilage ; surgery ; Cleft Lip ; surgery ; Humans ; Nose ; surgery ; Oral Surgical Procedures ; methods ; Rhinoplasty ; methods ; Surgical Flaps