After removal of unilateral molars in the rats,the changes in the articularcartilage and articular disc of the temporomandibular joint and HRP uptake of thelining cells of synovial membrane were observed with light,transmission and scanningmicroscopy.The HRP uptake activity of the lining cells was lowered and degenerative chan-ges were presented in ths articular cartilages following the removal of the molars.It is suggested that the temporomandibular joint is intimately integrated with theocclusion of the upper and lower teeth.Defect of the teeth on one side mayinduce occlusion disorders.These will certainly cause some changes of the structureand function of the temporomandibular joint.

The structure of the articular cartilage and disc of the temporomandibular jointin rats and monkey were studied with light,transmission and scanning electronmicroscopy.The articular cartilage covering the mandibular condyle is semilunar in shapeon cross section.Its thickest portion lies posterosuperiorly.The bony trabeculaesubjacent to the cartilage arrange vertically to the articular surface and concentrateto the thickest portion of the articular cartilage.The articular cartilage covering the mandibular fossa is similar to that on themandibular condyle,but contains fewer cartilage cells.Lacking a calcified areawith enlarged cartilage cells,the articular cartilage here may only be divided intothree areas.The articular disc consists of three areas:an upper,a middle,and a lowerone.The structure and ultrastructure of different parts of these cartilages with theirfunctions have been discussed.

BACKGROUND: As a result of immature brain of children and their imperfect blood brain barrier, improper clinical treatment would affect growth and development of children. It is fully important to perform further investigation on immature brain injury induced neurodegeneration.OBJECTIVE: To observe the ultramicrostructure of neurons in homolateral parietal cortex and hippocampus in newborn 7-day SD rat with contusion of parietal cortex.DESIGN: Completely randomized controlled trial.SETTING: Laboratories of Nerve Morphology and Cytobiology, Medical College of Shanghai Jiaotong University; Electron Microscope Room of Institute for Physiology, Chinese Academy of Science.MATERIALS: The experiment was performed in Teaching and Research Section of Anatomy, Laboratories of Nerve Morphology and Cytobiology ofShanghai Second Medical University (Medical College of Shanghai Jiaotong University; Electron Microscope Room of Institute for Physiology of Chinese Academy of Science from October 2002 to June 2003. A total of 19newborn 7-day SD rats were randomly divided into experimental group, operation control group and normal control group with 15, 2 and 2 in each group respectively.METHODS: In experimental group, free-fall device for brain injury was used for establishing model of contusion of parietal cortex in newborn 7-day SD rat. Anesthesia and scalp incision were conducted, without using free-fall device in operation control group. But above procedures were not carried out in normal control group. The changes of ultramicrostructure were observed under transmission electron microscope after routine treatment of electron microscopic samples.MAIN OUTCOME MEASURES: Ultramicrostructure of neurons in homolateral parietal cortex and hippocampus.RESULTS: All the 19 rats entered results analysis. ① There were two sorts of morphological changes in neurons in experimental group. One was evident swelling of dendrites and bodies of neurons, accompanied with the changes of organelles. In the early stage, expansion of endoplasmic reticulum cisterna could be observed and mitochondria became compact and concentrated. Then, vacuolization of endoplasmic reticulum, progressive swelling and vacuolization of mitochondria, dissociation of polysomes from rough endoplasmic reticulum and scattering of them in cytoplasm could be seen. Changes of nucleolus presented after significant changes of cytoplasm. Nuclear chromatin clustered together under karyotheca and arranged as clockface, which were some masses with irregular contours gathering to the center. Axons were almost normal. The other was concentration of cytoplasm and nucleolus with vacuolizations of unequal size in cytoplasm. ②There was no abnormal change in neurons in homolateral parietal cortex and hippocampus both in operation control group and normal control group.CONCLUSION: Swelling of brain cell and concentration of cytoplasm and nucleolus after brain injury play important roles in brain injury-induced neurodegeneration of immature rats.

Objective:To apply multiple mandibular anatomical landmark points to establish the mandibular median sagittal plane to find and establish the ideal median sagittal plane of the mandible that is suitable for clinical diagnosis and treatment.Methods:The maxillofacial spiral CT data of 30 normal maxillofacial patients in the Western Theater General Hospital were collected, and the 3D cranial model was reconstructed by using Mimics Research 21.0 software to select different anatomical landmarks to establish multiple mandibular MSPs, and with the whole cranial MSP as a reference, the different MSPs were respectively used as the mirror planes to establish a mirror model. The overlap of the original model and the mirror model were compared qualitatively and quantitatively by the overlap three-dimensional color illustration of 3-Matic software and Friedman′s test, respectively, to evaluate the application effect of different planes as mandibular MSPs.Results:There was a statistically significant degree of overlap between the mandibular mirror model and the original model with the whole head MSP and the different mandibular MSPs as mirror planes, respectively (χ 2=12.34, P<0.05). The mirror model of plane Mf-Go-Sim had the smallest overlap with the original model 0.07 (0.04, 0.18) mm; plane N-ANS-PNS was the second smallest 0.14 (0.09, 0.58) mm; the difference in overlap of plane ANS-SBWG-Mp 0.12 (0.04, 0.40) mm; the difference in overlap of plane Me-B-Sim 0.19 (0.09, 0.44) mm; the difference in overlap of plane Po-B-Go 0.18 (0.06, 0.45) mm. Conclusions:Whole-head MSP cannot completely replace mandibular MSP; plane Mf-Go-Sim can be the ideal MSP for the mandible in clinical applications.

Objective To evaluate the efficacy and safety of continuous femoral nerve block (CFNB) versus patient controlled analgesia (PCA) for analgesia in primary total knee arthroplasty (TKA) through a Meta-analysis.Methods All randomized controlled trials (RCTs) which compared about the efficacy and safety of CFNB versus PCA for analgesia in primary TKA,were searched from Cochrane Library,Embase,PubMed,CBM,VIP,Wang Fang database and CNKI.At the same time,conference papers were identified manually.A quality assessment of the included literature was evaluated by Cochrane system evaluation manually.Revman 5.3 software was used for the Meta-analysis to compare visual analogue scale (VAS),hospital for special surgery knee score (HSS),western Ontario and McMaster university of orthopedic index (WOMAC),patient satisfactory degree,and incidences of complications (nausea,vomit,dizziness,somnolence,itch of skin,etc).Results Twenty-four RCTs involving 1896 patients were identified including CFNB (946 cases) and PCA (950 cases) application of TKA.The pooled results illustrated that CFNB could reduce VAS in rest (MD =-1.28,95％ CI-1.56,-1.00,P ＜ 0.05) and VAS in movement (MD =-0.98,95％ CI-1.38,-0.58,P ＜ 0.05),increase HSS (MD =2.13,95％ CI 0.12,4.14,P ＜0.05),reduce WOMAC(MD =-0.97,95％ CI-1.83,-0.11,P ＜ 0.05),increase patient satisfactory degree (RR =1.27,95 ％ CI 1.10,1.46,P ＜ 0.05) and at the same time reduce the incidences of nausea,vomit,dizziness,somnolence and itch of skin (RR =0.32,95％CI0.24,0.43,P＜0.05).Conclusion Compared with PCA,CFNB analgesia can reduce VAS,WOMAC score,improve the postoperative HSS and patient satisfaction degree,and decrease the risk of complications.