Objective: To evaluate the influence of anti-anxiety nursing intervention to advanced lung cancer and its effect on cancer-related fatigue (CRF). Methods: Total of 48 advanced lung cancer patients were assigned to study group (24 cases) and control group (24 cases) by random digits tale method. The control group adopted routine nursing mode, while the control group increased anti-anxiety nursing intervention. All patients were assessed with Piper Fatigue Correction Scale (Revise-Pfs), Self-rating Anxiety Scale (SAS) and WHO Quality of Life Scale (WHOQOL-BREF). Results: Cancer-related fatigue was common among advanced lung cancer patients. There was no significant difference in the all scales before intervention between two groups (P >0.05). After intervention, the score of Revise-Pfs, SAS, WHOQOL-BREF was (5.24±1.57), (38.17±5.46), (73.17±2.62) points in control group, and (4.94 ± 1.15), (30.97±4.64), (81.35±3.01) points in study group, there was significant difference between two groups (t =1.21, 8.74, 1.43, P<0.05). Conclusions The anti-anxiety nursing is effective and CRF could be relieved by this way.