1.Efficacy of aminophylline and methylprednisolone in the treatment of bronchial asthma
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):244-246
Objective To investigate the clinical effect of methylprednisolone and aminophylline on bronchial asthma patients, so as to improve the level of clinical treatment. Methods Selected form August 2014 to June 2016 in our hospital diagnosed with bronchial asthma in 90 patients as the research object, for the normal group and the treatment group in accordance with the double blind method standard for sharing, the former the latter with aminophylline treatment; Methylprednisolone Treatment on the basis of the former treatment. After treatment, the statistical comparison of two groups and the clinical symptoms and quality of life to improve the situation. Results the total efficiency of the treatment group was 97.8%, significantly higher than that of the control group 77.8%(P<0.05). The treatment group of clinical symptoms and signs scores were lower than those of the reference group; improving the quality of life was better than the reference group, there were significant differences between groups of data comparison, statistical significance was established(P<0.05). Conclusion Patients with bronchial asthma by aminophylline combined with methylprednisolone treatment, the effect is considerable, not only can improve the treatment effect, rapidly relieve symptoms, improve the quality of life of patients, suggest further promotion.
2.THE VESSELS OF THE SKIN FLAPS AT GROIN REGION——1. THE MACRO-MICRO-ANATOMY OF THE SUPERFICIAL CIRCUMFLEX ILIAC VESSELS
Eryu CHEN ; Gwangtsi HO ; Gengli CHENG ; Zhengjin LIU
Acta Anatomica Sinica 1957;0(04):-
In many textbooks and literatures the superficial circumflex iliac artery (SCIA) is generally described, but only its superficial main branch (SMB) is referred, Its deep main branch (DMB) is always neglected, though it is present constantly. In 56% of fifty cases we studied the SCIA trunk possesses both these main branches.The SMB is present in 86% of the cases studied. After it originates from the trunk, it usually emerges promptly from the back of deep fascia into the subcutaneous layer. The points of emergence were found in an area around a center located 15 mm lateral and 10 mm below the origin of femoral artery. The course of the SMB can be marked as a line which located between a point 15 mm below the origin of femoral artery and anterior superior iliac spine. The SMB supplies an area along the lateral half of inguinal ligament, and its terminal branch usually turns upwards to the lateral portion of the abdominal wall.The DMB is a constant branch in our cases. It runs parallel to and 15mm beow the inguinal ligament, It supplies the upper lateral portion of the thigh, and its terminal branch usually turns downwards and laterally into the superficial layer of the gluteal region. The site where the DMB penetrates the deep fascia was found in an area around a center located 20 mm below the anterior superior iliac spine.The caliber of each of the two main branches is intimately correlated with the size of the skin which supplies. The course of the(SCIV)is similar to one of the main branches of the SCIA or runs between them (70%) The axes, thickness, size of the groin skin flaps were discussed.
3.MORPHOLOGY OF HUMAN FIBULA
Zhengjin LIU ; Gwangtsi HO ; Eryu CHEN ; Gengli CHENG
Acta Anatomica Sinica 1955;0(03):-
1000 fibulae of Chinese adults were observed and measured. It was found that the angle between the capital articular surface and the long axis of fibula is positively correlated with the circumference of the fibula. In 84.3% among the 1000 specimens, the body of the fibula posesses four borders and four surfaces. It would be more rational, if the nomination of these surfaces were based on their muscle attachments.The average maximum length of the fibula is 340.42?22.76 mm, the smallest circumference is 33.68?4.40 mm, the middle circumference is 39.52?4.99 mm. The caliber index, middle caliber index and the diaphyseal index were calculated respectively. The results obtained show that the side difference as a whole was statistically insignificant, but the diameter at the middle part is an exception. In the paired bones, there are more cases with larger circumference and diameter at the middle on the right side than on the left.According to our observations, some of the relationships between the morphology and function of the fibula were discussed.
4.THE VESSELS OF THE SKIN FLAPS AT GROIN REGION Ⅲ. THE MACRO-MICRO-ANATOMY OF THE SUPERFICIAL EXTERNAL PUDENDAL VESSELS
Eryu CHEN ; Gwangtsi HO ; Gengli CHENG ; Zhengjin LIU
Acta Anatomica Sinica 1955;0(03):-
In 82% of fifty groin regions of the cadavers studied, the superficial external pudendal artery (SEPA) possesses an upper and a lower main branches (UMB, LowMB). In 66% of them, the two main branches come from one common trunk and in the rest, they arise independently. Most of the SEPA trunks or main branches arise from the femoral artery. The penetrating points of the SEPA trunk or main branches through the cribriform fascia are located at the medial or lateral margin of the terminal end of the great saphenous vein around a center 10 mm medial and 50 mm distal to the origin of femoral artery. If the SEPA trunk or main branches are crossing the great saphenous vein, it is frequently found that the SEPA trunk and LowMB are crossing behind but the UMB in front of it.The UMB supplies the suprapubic, prepubic and medial part of the inguinal regions. A line which connects a point 50 mm distal to the origin of femoral artery with the pubic tubercle is suggested as the axis of UMB free skin flap. The LowMB supplies the upper part of anterior medial femoral and prepubic regions. A line which is parallel to the pubic crest and 50 mm distal to the origin of femoral artery is suggested as the axis of LowMB free skin flap. The caliber of each of the two main branches is intimately correladed with the area of the skin which they supplied.In 82% of cases, two sets of superficial veins are not present. These superficial external pudendal veins are also the accompanying veins of the corresponding arteries.The advantages of using these vessels as skin flap pedical vessels were discussed.
5.Salivary duct carcinoma associated with giant cell tumor: A case report.
Zhengjin LIU ; Ping YIN ; Yong-Gang CHEN ; Hongfeng LIAO ; Yan LÜ
West China Journal of Stomatology 2013;31(3):317-329
Primary salivary duct carcinoma(SDC) featured with giant cell tumor(GCT) is a extremely rare, relatively new understanding lesion and its histogenesis has not been fully defined. This paper reported a case of SDC associated with GCT, its clinical, histopathologic features and histological origin were discussed in combination with literature review.
Carcinoma, Ductal
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Carcinoma, Squamous Cell
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Giant Cell Tumors
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Head and Neck Neoplasms
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Humans
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Salivary Ducts
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Salivary Gland Neoplasms
6.Dataset collection and visualization for first visible human female in China
Shaoxiang ZHANG ; Zhengjin LIU ; Liwen TAN ; Mingguo QIU ; Qiyu LI ; Kai LI ; Gaoyu CUI ; Yanli GUO ; Guangjiu LIU ; Jinglu SHAN ; Jijun LIU ; Weiguo ZHANG ; Jinhua CHEN ; Jian WANG ; Wei CHEN ; Ming LU ; Jian YOU ; Xueli PANG ;
Journal of Third Military Medical University 1988;0(05):-
Objective To build the dataset of Chinese visible human female. Methods After undergoing macroscopical, CT and MRI examinations to exclude organic lesions, a young female cadaver of medium height was selected as the subject. After morphological measurement and vascular perfusion, the cadaver was embedded with 5% gelatin and cryopreserved in a -30 ℃ icehouse for 1 week. A digital milling machine TK 6350 (milling accuracy of 0.001 mm) was used to shave off slices of the body layer by layer from head to foot in a laboratory at -25 ℃. The successive cross sections were photographed with a high definition digital camera, and the pictures were put into a computer to establish a dataset of human body. By utilizing the image dataset derived from the successive cross sections, 3D reconstruction and stereodisplay of human structure were finished with a SGI Workstation which was equipped with an independently self developed software package for 3D reconstruction. Results The selected specimen, a 22 year old female native of Chongqing, was 1 620 mm in height, 54 kg in weight and died of non organic disease. CT scans were made in every 1.0 mm for head and neck and every 2.0 mm for rest parts, and the thickness for MRI scans was 1.5 mm for head and 3.0 mm for rest parts. For serial cross sections, the thickness was 0.25 mm for head and 0.5 mm for rest parts. Thus, a total of 3640 slices were obtained, and the photo for every slice was saved as a 36 MB file in a resolution of 6 291 456 pixels (3 072?2 048). Finally, the complete data files reached to 131.04 GB. Conclusion ① This is the first formally reported case of Chinese visible human female, suggesting that China becomes the second country owning visible human female dataset of her population. We set up a website for the purpose of exchanging ideas and information on this subject. So, the results are issued simultaneously on the Internet (http://www.chinesevisiblehuman.com).② According to US Visible Human Project(VHP), the data of the 3 junctional parts of their female cadaver were absent because the body was cut into 4 segments. Taking the age of 59 year old into account, the visible human female's body was not exactly perfect. The sections of 0.33 mm in thickness were saved to pictures at a resolution of 2 490 368 pixels (2 048?1 216). While, the first Chinese visible human female reported here is a young female without organic disease or lesion. No sectional datum is lost for being acquired from successive sections of the whole body. The resolution of cross sectional image reaches to 6 291 456 pixels (3 072?2 048).
7.Visualization of the first Chinese visible human male and female
Shaoxiang ZHANG ; Pingan WANG ; Zhengjin LIU ; Liwen TAN ; Mingguo QIU ; Qiyu LI ; Kai LI ; Gaoyu CUI ; Yanli GUO ; Guangjiu LIU ; Jinlu SHAN ; Jijun LIU ; Weiguo ZHANG ; Jinhua CHEN ; Jian WANG ; Wei CHEN ; Ming LU ; Jian YOU
Journal of Third Military Medical University 2003;0(07):-
Objective To achieve computer visualization of the first Chinese visible male and female Methods After acquisition of the dataset of the first Chinese visible male and female (2 518 cross sections were obtained from the visible male, the complete data files take up 90 468 GBs; while 3 640 cross sections from the female, the complete data files take up 131 04 GBs ), we processed 2 D images in an SGI Workstation and on P4 computer respectively Then, image registration was performed through reserved scaling point Reconstruction was achieved by two approaches: volume rendering reconstruction and surface rendering reconstruction Results We visualized the whole body and special parts of Chinese visible male and female on an SGI Workstation and a personal computer respectively Furthermore, by optimizing 3 D reconstruction and data processing technique, interactive 3 D visualization of the dataset was achieved Conclusions ①The dataset of the first Chinese visible male and female proves to be eligible for 3 D visualization research ②The platform setup of interactive 3 D visualization of Chinese visible male and female dataset provides foundation for digital human anatomy and virtual surgery ③The models of human organs and parts built through data segmentation, classification, registration and drawing lay basis for rendering complex structures of the whole human body delicately
8.The third Chinese visible human dataset produced
Shaoxiang ZHANG ; Zhengjin LIU ; Liwen TAN ; Mingguo QIU ; Qiyu LI ; Kai LI ; Gaoyu CUI ; Yanli GUO ; Guangjiu LIU ; Jinlu SHAN ; Jijun LIU ; Weiguo ZHANG ; Jinhua CHEN ; Jian WANG ; Wei CHEN ; Ming LU ; Jian YOU ; Xueli PANG ;
Journal of Third Military Medical University 2003;0(15):-
Objective To establish more detailed dataset of Chinese visible human male. Methods After undergoing macroscopical, CT and MRI examinations to exclude organic lesion, a young aged, middle sized male cadaver was selected as the subject. First, morphological measurement and vascular perfusion were performed. Second, after embedding with 5% gelatin, the cadaver was put in ice house and frozen to -30 ℃ for 1 week. Third, TK 6350 numerical control milling machine (milling accuracy of 0.001 mm) was used to shave off slices of the body layer by layer from head to foot at -25 ℃ in low temperature laboratory. Fourth, the successive cross sections were photographed with high resolution digital camera and scanned into an animation computer. Thus, data acquisition from cadaver model was completed to obtain structural dataset of the human body. Results The selected sample was a 21 year old, 1 820 mm in height, 66 kg in weight male died due to non organic disease. CT with 1.0 mm slice thickness for the head and neck and 2.0 mm for the rest of the body was performed. MRI with 1.5 mm slice thickness for the head and neck and 3.0 mm for the rest of the body was also performed. A total of 18 398 serial cross sections with the thickness of 0.1 mm of each section were obtained. The digital photographs were sampled at a resolution of 10 989 056 (4 064?2 704) pixels. The data file of each section occupies 62.9 MB. The complete data files occupy 1 157.23 GB. The research results are issued simultaneously on the Internet (http://www.chinese visiblehuman.Conclusion ① Review of the related literatures reveals that the thinnest thickness of the reported cross section of the visible human dataset is 0.2 mm(the thickness of the sections of the skull base of the first case of Chinese visible human reported by our research group is 0.1 mm.), and the slices consist of several thousands of serial cross sections with several millions of pixels. The data files occupy several tens of GB or more than 100 GB. However, the thickness of the cross sections of the whole body of the dataset achieved in our research is 0.1 mm. The total slices consist of 18 398 serial cross sections with the photographic resolution of 11 million pixels and the total data file reaches 1 157.23 GB. The three indexes mentioned above are elevated by 1 log unit. ② We have solved the key technical problems in data acquisition of visible human such as super thin serial cross sectioning, enormous quantity of data storing and display of tiny blood vessels.
9.Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography
Peijie ZHU ; Weijia CHEN ; Qiqin WANG ; Huihui WU ; Meng RUAN ; Hongwu WANG ; Zhengjin JIANG
Journal of Pharmaceutical Analysis 2022;12(2):332-338
In this research,a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine and ethylene dimethacrylate to mimick bio-membrane environment.Excellent physicochemical properties of this novel monolith that were achieved included column efficiency,stability,and permeability.Moreover,the biomimetic monolith showed outstanding separation capability for a series of intact proteins and small molecules.In particular,it exhibited good potential as an alternative to the commercial immobilized artificial membrane(IAM)column(IAM.PC.DD2)for studying drug-membrane interactions.This study not only enriched the types of IAM stationary phases,but also provided a simple model for the prediction of phosphatidylethanolamine related properties of drug candidates.