Objective To explore the rules of skin metastasis so as to make correct diagnoses. Methods The clinical and pathological data of 108 cases with skin metastasis were collected, reviewed and analyzed.Results There were 65 male and 43 female among those 108 cases, with an average age of 49 8 years. The metastasis occurring regions in turn were abdomen, chest, shoulder-back, waist-glutea, head-neck, extremities, perineum, vulva and whole body. The average time of the appearance from skin mass to diagnosis was 3 5 months. Skin metastasis occurred at mean 16 2 months after diagnosis of primary tumor. The commonest sites of original tumor were lung, large intestine, stomach, unknown primary site and esophagus in male,breast, large intestine, ovary, lung and unknown primary site in female respectively.Conclusions In consistent with cancer morbidity,the cancer with high incidence has a high skin metastasis rate. Skin metastasis often appeared on the skin near primary lesion. It should be suspected to skin metastasis,if skin nodule appears on patient with cancer history.

Transient receptor potential vanilloid-1(TRPV1) channel is a non-selective ligand-gated cationic channel with multiple activation mechanisms in the transient receptor potential subfamily. In recent years, a large number of studies have found that TRPV1 plays an important role in the field of cardiovascular diseases such as hypertension and atherosclerosis. With the in-depth study of traditional Chinese medicine, it has been found that Chinese medicine monomers and their active components can activate or inhibit TRPV1 channels, which has certain potential in the study of cardiovascular diseases. In this paper, the role of TRPV1 channel in cardiovascular diseases and the research progress of traditional Chinese medicine prevention and treatment of cardiovascular diseases based on TRPV1 channel are reviewed, in order to provide new ideas for prevention and treatment of cardiovascular system diseases.