Objective To explore the rules of skin metastasis so as to make correct diagnoses. Methods The clinical and pathological data of 108 cases with skin metastasis were collected, reviewed and analyzed.Results There were 65 male and 43 female among those 108 cases, with an average age of 49 8 years. The metastasis occurring regions in turn were abdomen, chest, shoulder-back, waist-glutea, head-neck, extremities, perineum, vulva and whole body. The average time of the appearance from skin mass to diagnosis was 3 5 months. Skin metastasis occurred at mean 16 2 months after diagnosis of primary tumor. The commonest sites of original tumor were lung, large intestine, stomach, unknown primary site and esophagus in male,breast, large intestine, ovary, lung and unknown primary site in female respectively.Conclusions In consistent with cancer morbidity,the cancer with high incidence has a high skin metastasis rate. Skin metastasis often appeared on the skin near primary lesion. It should be suspected to skin metastasis,if skin nodule appears on patient with cancer history.