[ABSTRACT]AIM:Toobservetheeffectsofpuerarincombinedwithsaxagliptinonrenalfibrosisintype2dia-betic rats.METHODS:Fifty male Wistar rats were used, of which 8 rats were randomly chosen as normal control group , and the remaining rats were used to establish the type 2 diabetic model.The rats that met the criterion for the diabetic mo-del were randomly divided into model group , puerarin treatment group , saxagliptin treatment group , puerarin combined with saxagliptin treatment group and metformin combined with saxagliptin treatment group .The above-mentioned drugs were ad-ministered for 8 weeks.After that period, all rats were sacrificed.The kidney index (kidney weight/body weight),and blood glucose and HbA1c were examined in all the rats.The morphological changes were observed by HE and Masson stai-ning.The levels of TNF-αand macrophage migration inhibitory factor (MIF) in the serum were measured by ELISA .The mRNA expression of TNF-α, MIF and CD68 was examined by RT-PCR.RESULTS: Compared with normal group , the kidney index, blood glucose and HbA1c, the levels of TNF-αand MIF in the serum and the mRNA expression of TNF-α, MIF and CD68 were increased (P<0.05) in the kidney tissues of model group .Compared with model group , the kidney index, blood glucose and HbA1c, the levels of MIF and TNF-αin the serum and the mRNA expression of TNF-α, MIF and CD68 were decreased ( P<0.05) in puerarin combined with saxagliptin treatment group .CONCLUSION:Puerarin com-bined with saxagliptin reduces blood glucose , decreases MIF and TNF-α, and down-regulates the mRNA expression of TNF-α, MIF and CD68 in the kidney tissues of type 2 diabetic rats, which may contribute to the inhibition of renal fibrosis .

Objective To analyze the diagnostic radiology equipment number,radiological staff structure,protection allocated at the medical institutes in Jiaxing city,with the purpose to provide basic data for the further optimization of resource allocation.Methods As required by the national radiation health monitoring program and using the stratified random sampling method,a total of 111 hospitals at grades Ⅲ,Ⅱ,Ⅰand other types were used to select 50％radiological institutions in Jiaxing.Unified questionnaires were used to investigate the basic situation in these hospitals,such as diagnostic radiology equipment,configurable protection equipment,radiation worker number and diagnostic frequency.Results The hospital number at grades Ⅲ,Ⅱ,Ⅰand other types accounted separately for 13.5％,21.6％,46.9％and 18.0％of the total.The equipment numbers for radiotherapy,nuclear medicine,interventional radiology and X-ray imaging at grade Ⅲ hospitals accounted for 100％,100％,57.9％and 38.0％,respectively,significantly higher than others.The numbers of conventional photofluorography and fluoroscopy equipment at grades Ⅰhospitals accounted for 34.2％and 50％,slightly higher than others ;CT and mammography devices were distributed at the grades ⅡandⅢhospitals.The frequencies at X-ray diagnosis,CT diagnosis and interventional therapy and diagnosis,radiotherapy,and nuclear medicine diagnosis and therapy were 178.9,157.5,3.1,1.5,2.2 and 0.1 per thousand person-year in Nanhu district,which were higher than in the other areas of Jiaxing city.Conclusions Grade Ⅲhospitals have more diagnostic radiology devices and radiation workers than in non-grade-Ⅲ hospitals.These hospitals were all equipped with adequate amount of protection equipment.The frequency of diagnostic radiology in Nanhu district hospital was significantly higher than that in other district hospitals.

Objective To ascertain the background levels of total α and total β radioactivity in drinking water around Qianshan Nuclear Power Plant (QNPP). Methods Under the National Health and Wellness Committee′s program, 11 monitoring points within 30 km of QNPP were selected in Haiyan County in 2018. The samples of raw water, factory water and tap water were collected in the first half and the second half of the year, respectively, and determined and analyzed according to Standard Examination Methods for Drinking Water - Radiological Parameters (GB/T 5750.13-2006). The total α and total βlevels in the tested drinking water were evaluated under the Standards for Drinking Water Quality ( GB 5749-2006) . Results A total of 22 water samples were collected from 11 sampling points in April and September 2018, respectively. The residue rate obtained after drinking water was dried varied, dependent on different types of water, which could be up to 0.0337％. The total α levels in different types of water ranged from 0.008 to 0.04 Bq/L, averaged on (0.015±0.009) Bq/L, whereas the total β levels ranged from 0.014 to 0. 320 Bq/L with an average of ( 0. 188 ± 0. 068) Bq/L. There was statistically significant difference in totalαlevels between raw water and factory water ( Z=-2.286, P<0.05) , without statistically significant difference between residue rate and totalαand totalβlevels ( P>0.05) . The background levels of total α and total β radioactivity in 93 drinking water samples in 2016 and 2017 were also investigated, combined with a total of 115 water samples from different water bodies in 2018. There was statistically significant difference in total α and total β levels in tap water between 2017—2016 and 2018 ( Z=-2.976, -2.031, P<0.05), between 2016 and 2017 (Z=-2.042, -3.214, P<0.05) and between 2017 and 2018 (Z=-20. 112, -2.511, P<0.05). Conclusions The operation of nuclear power plant has no impact on radioactivity level in drinking water around QNPP. The drinking water around QNPP is safe.