Objective:To investigate the influence of practolol oral liquid on the rat model of water load. Methods: Totally 70 qualified rats were selected and randomly divided into seven groups with 10 ones in each, and the rats were with intragastric administra-tion respectively by practolol oral liquid (20,10 and 5 ml·kg-1 , respectively diluted 20 ml, 10 ml and 5 ml to 20 ml liquid with dis-tilled water), furosemide tablets suspension (0. 033 5 mg·ml-1), Qiliqiangxin capsule suspension(0. 03 g·ml-1) and distilled wa-ter with the same voulme( model) . The rats were placed in metabolism cages. After the administration, the urine volume was recorded every 1 h for 5 hours, the total volume of urine was collected during the 5 h, and the concentration of Na+, K+ and Cl- in the urine was measured. Results:Compared with that in the blank group, the urine volume in 2 h, 3 h and 5 h after the administration in the model group was significantly increased(P<0. 01), the total urine volume was also increased significantly(P<0. 01), the K+ con-centration was significantly reduced in the urine(P<0. 05), and there was an increasing trend of Na+ and Cl- concentration in the u-rine, which indicated that the water load model was made successfully. Compared with the model group, furosemide could significantly increase the urine volume in 1 h, 2 h, 3 h, 4 h and 5 h after the administration, and the total urine volume was increased as well ( P<0. 01). Qiliqiangxin capsule group could significantly increase the K+ concentration in the urine(P<0. 05), and furosemide could significantly reduce the K+ concentration in the urine (P<0. 05). High-dose practolol oral liquid could significantly increase the urine volume in 5 h after the administration and the Na+ and Cl- concentration(P<0. 01), mid-dose practolol oral liquid could significantly increase the urine volume in 3 h and 5 h after the administration and the total urine volume (P<0. 05), and improve the Cl- concen-tration in the urine (P<0. 05), and the Na+ and Cl- concentration in low-dose practolol oral liquid group was decreased significantly (P<0. 01). Compared with Qiliqiangxin capsule group, the high, medium and low-dose practolol oral liquid showed no significant in-fluence on the urine volume(P>0. 05), high-dose practolol oral liquid could significantly increase the Na+ concentration in the urine (P<0. 01), medium and low-dose practolol oral liquid could significantly increase the Na+ concentration in the urine(P<0. 05), low-dose practolol oral liquid could significantly reduce the K+ concentration(P<0. 01), high and medium-dose practolol oral liquid could significantly increase the Cl- concentration in the urine (P<0. 01), and low-dose practolol oral liquid could significantly reduce the Cl- concentration in the urine (P<0. 01) . Compared with the high-dose practolol oral liquid group, the influences of medium and low-dose practolol oral liquid showed no significant difference in the urine volumes(P>0. 05), however, the total urine volume could significantly increase(P<0. 01), and the medium and low-dose practolol oral liquid could significantly reduce the Na+ and Cl- con-centration in the urine(P<0. 01). Conclusion:Practolol oral liquid has significant diuretic effect in a dose-dependent manner.

Objective:To observe the effect of Erfukang oral liquid on microcirculation disturbance in mice with acute blood stasis caused by adrenaline. Methods:The mice were randomly divided into the blank group,Naodesheng group(1.35 g·kg-1),Erfukang oral liquid group respectively at high(30 ml·kg-1),medium(15 ml·kg-1) and low(7.5 ml·kg-1) dose,and a microcirculation apparatus was used to observe the number of capillary opening in the normal mice at one hour after the administration. The microcircu-lation disturbance of auricle was induced by the injection of epinephrine into caudal vein. The number of capillary opening and blood flow in 2 min in the mice were observed. Results:Compared with the blank group,Ergukang oral liquid at high,medium and low dose showed effect on the number of opening capillaries without statistical significance (P>0.05);compared with the model group, Erfu-kang oral liquid at high and medium dose could significantly improve the microcirculation induced by epinephrine (P<0.05 or P<0.01),and significantly confront the decreased number of capillary network opening induced by adrenaline(P<0.05). Conclusion:Erfukang oral liquid can improve microcirculation disturbance.

Objectives To assess tyrosine kinase inhibitor (TKI) treatment status in patients with chronic myeloid leukemia (CML) in China and analyze the response-associated factors.Methods From May to November in 2014,anonymous questionnaires were distributed to adult CML patients who were receiving TKI treatment all over China.Results 1 038 questionnaires were collected,949 questionnaires were evaluable.Of the 949 evaluable respondents,549 (58％) were male with the median age of 41 years (range,18 to 88 years).623 (66％) respondents lived in an urban area and 449 (47％) had an education level ≥ a bachelor degree.888 (94％) respondents were in the chronic phase at diagnosis,and 690 (78％) of them started TKI treatment within one year after diagnosis.794 (84％) respondents were on imatinib,768 (81％) on the branded.With a median TKI treatment duration of 3 years (range,＜1 to 13 years),708 of 834 (85％) evaluable respondents achieved Ph-negative (i.e.complete cytogenetic response,CCyR),and 497 of 859 (46％) BCR-ABL negative (i.e.complete molecular response,CMR).Multivariate analyses showed that female (OR=l.8,95％ CI 1.1-2.8,P=0.019 and OR=l.5,95％CI 1.1-2.0,P=0.015),TKI treatment duration ＞3 years (OR=4.1,95％CI 2.6-6.5,P＜0.001 and OR=3.7,95％CI 2.7-5.1,P＜ 0.001) and imatinib taken (OR=2.1,95％CI 1.2-3.7,P=0.007 and OR=3.3,95％CI 2.1-5.1,P＜0.001) were factors affecting achieving both CCyR and CMR.In addition,higher education level (OR=2.0,95％CI 1.3-3.1,P=0.003),starting TKI treatment ＜1 year (OR=2.4,95％CI 1.5-3.8,P＜0.001) and branded drugs received (OR=2.4,95％ CI 1.4-4.0,P=0.001) were factors affecting achieving a CCyR.In 884 respondents,534 (62％) reported "heavy financial burden" as the biggest treatment impediment,only 152 (17％) reported "poor quality of life related to adverse effects of TKI".Conclusions The survey showed that majority of the Chinese CML patients received imatinib as a TKI therapy,and most of the patients achieved satisfied responses by TKI.Financial burden became the major obstacle during TKI treatment.