ObjectiveTo investigate the effects of Monsel′s solution on bleeding in endoscopic sclerotherapy for esophageal varices. MethodsOne hundred and sixteen patients with cirrhosis and esophageal variceal bleeding who were admitted to our hospital from February 2013 to February 2015 were enrolled as subjects. All patients received endoscopic sclerotherapy. Forty-six patients had hemorrhage after removal of needles, and they were treated with topical spraying of 15% Monsel′s solution. The instant and long-term hemostatic effects were evaluated. ResultsAfter spraying of 15% Monsel′s solution, the immediate formation of coagulum and no bleeding were found in the bleeding spots of 46 patients undergoing bleeding in endoscopic sclerotherapy. At one week after surgery, the blood pressure, pulse, fecal occult blood, and routine blood indices were evaluated, and no signs of active bleeding were found. ConclusionThe response rate of topical spraying of Monsel′s solution is 100%. Moreover, with a convenient preparation, few adverse reactions, and low economic burden on patients, the simple method is the best choice in the treatment of bleeding in sclerotherapy.