1.Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice.
Lili DING ; Qiaoling YANG ; Eryun ZHANG ; Yangmeng WANG ; Siming SUN ; Yingbo YANG ; Tong TIAN ; Zhengcai JU ; Linshan JIANG ; Xunjiang WANG ; Zhengtao WANG ; Wendong HUANG ; Li YANG
Acta Pharmaceutica Sinica B 2021;11(6):1541-1554
Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders. We have identified notoginsenoside Ft1 (Ft1) from
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