OBJECTIVE: To investigate the antagonistic effect of Salvia miltiorrhiza on cyclosporine A (CsA)-induced chronic nephrotoxicity. METHODS: 54 patients underwent renal transplantation were divided into 3 groups according to dosage of salvia miltiorrhiza: CsA+high-dose of salvia miltiorrhiza group, CsA+loe-dose of salvia miltiorrhiza group (trial group) and CsA control group (control group). Plasma concentration of CsA, serum creatinine (Scr), blood urea nitrogen (Bun), 24 h urines and 24 h urinary protein were recorded. The parameters of morphology and hemodynamics were compared among 3 groups. The differences of index among 3 groups were analyzed statistically. RESULTS: The level of Scr, Bun and 24 h urinary protein in CsA+high-dose of salvia miltiorrhiza group were decreased significantly while 24 h urines was increased, compared with other 2 groups. There was significant difference among 3 groups (P0.05). The intrarenal blood flow and renal arterial resistance index were increased significantly in CsA+high-dose of salvia miltiorrhiza group. CONCLUSION: High-dose of salvia miltiorrhiza combined with CsA can reduce the CsA-induced nephrotoxicity perfently.

As the dressings currently used in clinic settings unflat shape in general, they can't be fitted completely on occiput, heel, elbow, knee and other body parts unflat. This paper developed one kind of foam dressing of special shape based on local anatomy. The foam dressing is waterproof and air permeable, it can cover the wound closely enough to prevent bacteria from invasion and infection. With a saturated absorption ratio of 1: 8 or higher, it can keep the wound clean and moisture by absorbing large amounts of wound inflammatory secretions and is almost completely permeable to oxygen and carbon dioxide. Assuring safety and effect meanwhile, it has better outcomes than common dressings in the same application settings.
Bandages ; Wound Healing

Adolescent ; Female ; Humans ; Leukemia ; etiology ; Leukemia, Promyelocytic, Acute ; complications ; Male ; Young Adult

Child ; Hematology ; history ; History, 20th Century ; History, 21st Century ; Humans ; Pediatrics ; history ; Societies, Medical ; history

BACKGROUND:The Notch signaling pathway is evolutionarily highly conserved and mediated by cel-cel interactions, which is widely involved in cel differentiation, proliferation and apoptosis. This critical transduction system participates in coordinating various functions of vascular endothelial cels, thus playing a vital role in the formation and remodeling of vascular network. OBJECTIVE: To elucidate the components of Notch signaling pathway and its impact on angiogenesis. METHODS: A computer-based online search of PubMed and CBM databases was performed. High-quality articles related to mechanism of angiogenesis regulated by Notch signaling were included, and repetitive studies were excluded. RESULTS AND CONCLUSION:Totaly 31 literatures were selectively included in this review. Angiogenesis is a complicated and muti-stage biological event and has been delicately regulated. Notch signaling participates in the regulation of every stage of angiogenesis directly or indirectly via the crosstalk with vascular endothelial growth factor, BMP-SMAD signaling and extracelular matrix molecules. Furthermore, consistent output of Notch signaling is essential for maintaining the stability and integrity of adult vascular system. This review wil thoroughly clarify the latest progress on angiogenesis regulated by Notch signaling and provide theoretical basis and a potential target for designing therapeutic methods against vascular disease.

Objective: To synthesize 10-position schiff base derivatives of emodin and study the anti-tumor activity. Methods:The 10-position schiff base derivatives of emodin were synthesized through emodin reacting with ammonia derivatives in absolute alcohol with acetic acid as the catalytic agent. Their structures were characterized by 1 H-NMR and ESI-MS, and the anti-tumor activity on k562 cells was determined by MTT method. Results:Three 10-position schiff base derivatives were synthesized and the structures were confirmed, and the IC50 on k562 cells was 4. 5, 3. 8 and 2. 0 μmol·L-1 , respectively. Conclusion:The 10-position schiff base de-rivatives of emodin can improve the anti-tumor activity and druggability of the parent compound, which are worthy of further study.

To observe the therapeutic effect of acupuncture and moxibustion on the climacteric syndrome, patients with climacteric syndrome were treated by acupuncture and moxibustion and randomly compared with the patients in control group treated by Chinese herbs. There was a significant difference between two groups (P＜0.05). The results showed that the therapeutic effect in acupuncture and moxibustion group was obviously better than that in Chinese herbs group.

Clinical effect is of great importance to traditional Chinese medicine (TCM), and the rigorous and scientific methods for clinical effect assessment should be highly stressed in the clinical research of TCM. In this article, the authors analyzed the current status of the effect assessment of TCM and proposed some measures to improve the current effect assessment of TCM, in the hope of establishing an internationally accepted system of effect assessment reflecting the superiority and characteristics of TCM therapies.

Neurobiology,one of the important subject in life science frontier,comprises extensive and comprehensive contents.It is significant and essential for each discipline of medicine to offer this course.During last several years of teaching and practice,some methods,skills and ideas have been utilized and summarized.Modem medical education,by offering this course,will accord with the development concept of the transition from biomedicine to bio-psycho-social medical model,and this course will provide the substantial foundation for cultivating qualified medical students.

The Laboratory medicine is a practice subject.Department of Medical Laboratory in the first clinical medicine college(Nanfang Hospital),Southern Medical University strengthens communication and cooperation with enterprises,such as third parted laboratory medicine institutions and independent laboratories.The enterprises participate in teaching work including reforming curriculum system.cultivating students'practice and innovation abilities,constructing exercitation bases,sdvancing students'occupation competition,and so on.Along with emphasizing practice and innovation abilities cultivation,the hospital-enterprise cultivation pattern for Laboratory medicine was established and made primary progress.