OBJECTIVE: To investigate the antagonistic effect of Salvia miltiorrhiza on cyclosporine A (CsA)-induced chronic nephrotoxicity. METHODS: 54 patients underwent renal transplantation were divided into 3 groups according to dosage of salvia miltiorrhiza: CsA+high-dose of salvia miltiorrhiza group, CsA+loe-dose of salvia miltiorrhiza group (trial group) and CsA control group (control group). Plasma concentration of CsA, serum creatinine (Scr), blood urea nitrogen (Bun), 24 h urines and 24 h urinary protein were recorded. The parameters of morphology and hemodynamics were compared among 3 groups. The differences of index among 3 groups were analyzed statistically. RESULTS: The level of Scr, Bun and 24 h urinary protein in CsA+high-dose of salvia miltiorrhiza group were decreased significantly while 24 h urines was increased, compared with other 2 groups. There was significant difference among 3 groups (P0.05). The intrarenal blood flow and renal arterial resistance index were increased significantly in CsA+high-dose of salvia miltiorrhiza group. CONCLUSION: High-dose of salvia miltiorrhiza combined with CsA can reduce the CsA-induced nephrotoxicity perfently.

Adolescent ; Female ; Humans ; Leukemia ; etiology ; Leukemia, Promyelocytic, Acute ; complications ; Male ; Young Adult

As the dressings currently used in clinic settings unflat shape in general, they can't be fitted completely on occiput, heel, elbow, knee and other body parts unflat. This paper developed one kind of foam dressing of special shape based on local anatomy. The foam dressing is waterproof and air permeable, it can cover the wound closely enough to prevent bacteria from invasion and infection. With a saturated absorption ratio of 1: 8 or higher, it can keep the wound clean and moisture by absorbing large amounts of wound inflammatory secretions and is almost completely permeable to oxygen and carbon dioxide. Assuring safety and effect meanwhile, it has better outcomes than common dressings in the same application settings.
Bandages ; Wound Healing

Child ; Hematology ; history ; History, 20th Century ; History, 21st Century ; Humans ; Pediatrics ; history ; Societies, Medical ; history

Objective To analyze the relative risk factors of elderly patients with abdominoperineal resection for rectal carcinoma.Methods The risk factors for hospital death and postoperative complications in 137 elderly patients who had undergone abdominoperineal resection for rectal carcinoma from July 1995 to July 2005 were analyzed retrospectively.Results The risk factors included coexistent diseases,hemoglobin level less than 70 g/L,body mass index(BMI)less than 18.5 kg/m2,intraoperative blood loss more than 1 000 ml,operating time longer than 6 h.The relative risk ratio were 4.76,5.85,6.49,5.47,3.90 respectively for hospital death,and 2.02,2.27,1.83,2.01,1.70 for postoperative complications.Conclusion The risk factors of the elderly patients with abdominoperineal resection for rectal carcinoma should be considered carefully during the perioperative period.

Objective To analysis the clinical characteristics of Tubal pregnancy.Methods 500 cases of tubal pregnancy were collected and clinicopathological changes,histopathologic feature were studied in 500 cases of tubal pregnancy,35 cases of them analyzed by electron microscope.Results Patholocal changes of the Fallopian tubes itself:Chronic nonspecific inflammation and peripheral inflammation of Fallopian tubes and endometriosis and the fatty infiltration of the tubal wall is 60%、2%、1.6%、0.8% and 2%.Conclusions The main pathological changes of fallopian tubes itself is chronic nonspecific inflammation.IUD and tubal sterilization and endometriosis and fatty inflitration of the tubal wall be causative of the tubal pregnancy.

Objective To study the relationship between the expression of matrix metalloproteinase-9 in rat brain and pathogenesis of epilepsy.Methods The expression of matrix metalloproteinase-9 in hippocampus was observed by immunochemistry in normal and epilepsy rat.Meanwile,the effects of dexamethasone before epilepsy on the expression of MMP-9 in hippocampus was evaluated.Results The expression of MMP-9 in hippocampus were fewer in normal rat brain.The expression of MMP-9 had increased in hippocampus after epilepsy 24h.It had increased obviously in dentate gyrus(DG)after epilepsy 72h than 24h(P0.05).Dexamethasone suppressed the expression of MMP-9 in hippocampus.Conclusion The expression of MMP-9 in rat brain participates in immunopathogenesis of epilepsy by affecting brain immunoreaction,leading to the change of neuronal response and synapse remodeling in hippocampus,regulating brain nervous cell excitability.Dexamethasone plays a prominent suppressant role in the processes.

Misoprostol, a prostaglandin E1 analogue, have variety clinical applications. In early 80's, misoprostol is currently licensed primarily to prevent non-steroidal anti-inflammatory drug-associated gastric and duodenal ulcers. Further work shows the drugs have protection to hepatic and renal and prevention of inflammatory and allergic disorders. When combined with mifepristone,complete abortion rate is 95%. On the other hand, misoprostol is also an effective agent for cervical ripening and labor induction. It have no serious side effect, as a result, misoprostol is a drug of high effect and low toxicity, deserving popularization, but man and pregnant woman must prudent.

Objective To study the application of complex surgical therapy of severe hepatic trauma and the flow line reasonable.Method To study the methods and reasonable process of complex surgical treatment of severe hepatic trauma pre-hospital or hospital treatment of 46 patients during the past 15 years.Results The time of sending to hospital was delayed.Patient has severe hepatic trauma or associated injuries.Patient can not be diagnosed definitely against time.Linear correlation was demonstrated between the three upon and shock (r=0.55,t=3.38,P

Objective: To research the application of perspective imaging of intense laser proton beam in tumor cells, experi-ments are carried out on an ultra-intense picosecond pulsed laser facility, and the results of perspective imaging on biological samples by high energy proton beam, which is excitated among the interaction of picosecond laser with solid target, is showed. Methods: The laser energy is 12 J, the pulse width of laser is 1.5 ps, the laser focal spot diameter is 15 μm, the coefficientf or the off-axis paraboloid lens is 1.5. The target used in the experiment is made by coating a CH film with 1 μm on the back of the 15 pan-thick Cu. The distance between the proton source (laser spot) and the ant sample is 7 mm (i.e. the object distance), the distance between the sample and the RC film is 63 mm (i.e. the image distance). The detector is a stack of RCF or CR-39 films. Results: The ant is taken as the sample, a high energy proton beam, which is excitated as above on the rear surface of target, makes a 2-dimensional perspective imaging of an ant with high contrast, nanometer spatial resolution and density reso-lution. Conclusions: The result provided possibility of the application of perspective imaging of intense laser proton beam in tumor cells.