Electromagnetic Fields ; adverse effects ; Health Policy ; Humans

Electromagnetic Fields ; adverse effects ; Humans ; Radiologic Health

Objective To analyse the relationship between the diagnosis of disseminated intravascular coagulation(DIC) and the level of Thrombomodumin(TM),thrombin-antithrombin(TAT) and D-dimer in plasma from 67 patients with disseminated intravascular coagulation(DIC).Methods The levels of TM,TAT and D-dimer were measured by a two antibody sandwich enzyme linked immunosorbent assay and a latex aggregation assay.Results The levels of TM,TAT and D-dimer in plasma of patients with DIC were higher than those in control group(P

OBJECTIVE:To investigate the value of genetic testing in clopidogrel individualized antiplatelet therapy for acute coronary syndrome(ACS)patients after percutaneous coronary intervention(PCI). METHODS:Clinical pharmacists participated in therapy for 3 ACS patients after PCI,and analyzed risk factors of stent thrombosis as the degree of lesion complexity,length and number of stents,complication,smoking history,etc. Clinical pharmacists suggested conducting clopidogrel genetic testing (CYP2C19,PON1,ACBC1),and suggested replacing antiplatelet agents,maintaining original plan and strengthening monitoring according to the results of genetic testing. RESULTS:The physicians adopted the suggestions of clinical pharmacists. After optimiz-ing antiplatelet therapy according to the results of genetic testing and clinical factors,3 patients were stable and discharged from hospital with drugs. CONCLUSIONS:Genetic testing can provide evidence for the formulation of individualized antiplatelet thera-py in ACS patients after PCI,and can be regarded as one of the breakthrough points for clinical pharmacists to carry out pharmaceu-tical care. In conducting genetic testing,clinical pharmacists should evaluate the risk of thrombosis in ACS patients and select the appropriate population for testing. At the same time,the clinical factors as medication compliance,stent thrombosis risk,therapeu-tic efficacy,ADR,and evidence-based pharmaceutical evidence should be comprehensively evaluated on the basis of genetic test-ing,and antiplatelet therapy plan should be optimized so as to guarantee the safety and effectiveness of drug use.

Electromagnetic Fields ; adverse effects ; Environmental Exposure ; adverse effects ; Humans ; Occupational Exposure ; adverse effects ; Radiation Monitoring ; methods ; Risk Assessment

Electromagnetic Fields ; adverse effects ; Humans ; Mutagenicity Tests

Cell Physiological Phenomena ; Electromagnetic Fields

Electromagnetic Fields ; Environmental Exposure ; Humans ; Hypersensitivity ; etiology

Objective To observe the effects of elevated temperatures(37~44.5℃)on the cell counts, hemolysis and osmotic fragility of stored red blood cells.Methods After 7~35 days of storage at 4℃, erythrocyte suspensions were heated by incubation at 37℃ and 44.5℃ for 30 min in an incubator and then examined for cell counts, hemolysis and osmotic fragility.Results Red blood cell, white blood cell and platelet counts, hemoglobin and potassium were unchanged following the heat treatment. In the osmotic fragility test, hemolysis remained within normal limits. Hemolysis of groups incubated at 37℃ and 44.5℃ began at (4.41?0.38)g/L and (4.3?0.2)g/L respectively while a complete hemolysis occurred at (3.42?0.36)g/L and (3.4?0.1)g/L , showing no significant difference compared to the room temperature control (4.5?0.18)g/L and (3.6?0.1)g/L. There was no significant distinction in the proportions of smooth spherocyte among the samples incubated at different temperatures, except the samples stored for 35 days, probably due to the long storage period.Conclusions Heating at temperatures between 37～44.5℃ for as long as 30 min does not cause hemolysis or other damage to red blood cells.

In recent years,health economics developed quickly,which attracted both international academic and public interested.Compared with the developed countries,although the study of health economics in China started relatively slow,it has already attracted more and more attention by the academic along with the rapidly social development.With the support from international organizations and academic institutions,China had gradually established its health economics research net from 1990s,the research system had been improved and a serious of research achievements had already playedmore important role in the procedure of government decision making.It summarized the research progress in the field of international and China's health economics so as to provide references for research and policies.