The rapid progress in surgery in China has been closely related to government investment in public health care, construction of medical talents team, and basic and clinical research. The achievements of bench studies promote the development of clinical surgery. Translational medicine (bench-bedside-bench) has gained much attention in the medical community. The driving force promoting long-term development of surgery in China includes collaboration of basic scientists and surgeons, cultivation of surgeons with aptitude in scientific research, initiation of clinical research and popularization of multidisciplinary team.
Biomedical Research ; China ; General Surgery ; Humans

Gastric cancer remains one of the most common causes of cancer-related death in China. Radical operation is the only potentially curative therapy for advanced gastric cancer (AGC). D2 radical gastrectomy has been widely accepted as a standard surgical procedure for patients with AGC in China. Several clinical trials have revealed that more extended resection than D2 surgery has no impact on survival. In order to improve the prognosis of AGC patients, it is necessary to carry out the preoperative TNM staging for selecting a reasonable therapeutical modality before surgery. Multimodality treatment involving perioperative chemotherapy, radiotherapy or molecular targeting agents in addition to surgery have been thought to be promising treatment strategy. In this article, we present an update on the current literature regarding the trends of surgical multimodal treatment for the patients with AGC.
Combined Modality Therapy ; trends ; Humans ; Stomach Neoplasms ; surgery

Objective To investigate the therapeutic effect of Qingyan Mixture for laryngeal cough patients with lung dryness due to yin deficiency. Methods Sixty laryngeal cough patients with lung dryness due to yin deficiency were evenly randomized into treatment group and control group. The treatment group was given oral use of Qingyan Mixture, and the control group was given oral use of Ketotifen and Carbetapentane. The course of treatment for both groups lasted for 10 days. The overall therapeutic effect, and the effect on individual symptom or sign were evaluated after treatment. Results ( 1) In the treatment group, six patients were cured, 14 were markedly effective, 8 were improved, 2 were ineffective and the total effective rate was 93.3%. In the control group, one case was cured, 7 were markedly effective, 17 were improved, 5 were ineffective and the total effective rate was 83.3%. The overall clinical effect in the treatment group was significantly higher than that in the control group (P<0.01) . (2) As for the effect on individual symptom or sign, the treatment group showed stronger effect on dry cough than the control group ( P<0.01) , while differences of dry pharynx, throat itching, foreign body sensation in the throat, and pharyngeal signs were insignificant between the two groups (P>0.05) . (3) After treatment, the total scores of main symptoms were decreased in both groups (P<0.05 or P<0.01) compared with those before treatment. Conclusion Qingyan Mixture shows certain effect on relieving symptoms and signs of laryngeal cough patients with lung dryness due to yin deficiency.

Hypoxic pulmonary hypertension(HPH) is a common disease featured by acute hypoxic pulmonary vasoconstriction(HPV) and chronic hypoxic pulmonary vascular remolding(HPVR) leading to the sustained increasing of pulmonary artery pressure.There are many mediators involved in the HPH but none can illustrate it successfully.Primary work has found 15-lipoxygenase(15-LO) and its catalyzed production 15-hydroxyeicosatetraenoic acid(15-HETE)(from arachidonic acid) are up-regulated in pulmonary vascular when exprosed to hypoxia.And it has been found 15-LO/15-HETE involved in many processes of both the HPV and HPVR,indicating 15-LO/15-HETE may be an important mediator of HPH.Advances research on 15-LO/15-HETE may illustrate the mechanism of HPH,and will give some message in looking for a potential clinical target of HPH.

Wnt signal transduction pathway plays a very important role in embryonic development, and its abnormality may lead to developmental defects and cellular malignant transformation. It has been shown that disturbances of the Wnt signal transduction pathway were significantly related to human neoplastic transformation. The core mechanism of the pathway abnormality was the accumulation of free ?-catenin protein in the cytoplasm and nucleus resulting in the expressions of specific target genes by downstream pathway. This paper reviews the composition and structural character, transduction and regulation of the Wnt signal pathway and its relation with human tumorigenesis.

OBJECTIVE:To evaluate the efficacy and safety of telmisartan in the treatment of hypertension.METHODS:The efficacy and safety of telmisartan versus losartan in treating hypertension reported in 5 studies were comprehensively evaluated with the meta-analysis in homogeneity test and combined test.RESULTS:Of the five randomized controlled trials(RCT) in which 771 patients who met the inclusion criteria were included,two studies were of high methodological quality according to Jadad scale.Meta analysis indicated that there was statistical significance between telmisartan and losartan in effectiveness(OR=1.55,95% confidence interval(1.12,2.16),P0.05).CONCLUSION:The effectiveness of telmisartan in the treatment of hypertension is significantly higher than that of losartan;however,there is no signficant differce in safety between the two drugs.

Objective To optimize the solvent extraction of Rhubarbs. Methods With different concentrations of alcohol as the solvent, the amount of solvent, the extracting time and the extracting frequencies were assayed by orthogonal test to detect their influences on the extraction rate of rhubarb anthraquinone. And the extracts were analyzed and their pharmacodymamic effects were studied. Results Indicated by the content of total anthraquinones, the best conditions was: reflux extraction with 5- fold 50 % alcohol for 3 times, 0.5 h per time. The purgative activity of the extracts was stronger than that in the positive control group. Conclusion Optimization of the extracting conditions can promote the purgative activity of the extracts. 

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

Patent foramen ovale(PFO)is a special kind of atrial septal abnormal communication with no significant hemodynamic abnormal shunting between the two atrial together with no correlative clinical signs and symptoms.During recent years,there is a new finding of PFO,concerning about the occurrences of abnormal embolism,stroke,migraine etc,which are closely or indirectly related with the existence of PFO.In addition,atrial septal bulging complicated with PFO is also a risk factor for cerebral infarction arousing the critical attention for this disorder.This article presents a comprehensive evaluation about the incidence,clinical features,diagnosis and preventive measures of PFO.