Electromagnetic Fields ; adverse effects ; Health Policy ; Humans

Animals ; Dogs ; Drug Evaluation, Preclinical ; methods ; Statistics as Topic

Electromagnetic Fields ; adverse effects ; Humans ; Radiologic Health

Comprehensive evaluation for colleges of stomatology is a complex systematic engineering, which is affected by the determination of index and weight. Based on the previous research results,this study establishes a comprehensive evaluation index for colleges of stomatology in China by applying Delphi method,carrying out two-round consultation to 45 experts,which includes 4 first layer indicators and 21 second layer indicators.

Objective:To investigate the efficacy of oseltamivir combined with LianhuaQingwen granule in the treatment of influenza. Methods:Ninety-two patients with influenza who received treatment in Wenzhou People's Hospital from October 2017 to October 2019 were included in this study. They were randomly assigned to receive treatment with Lianhua Qingwen granules (control group, n = 46) or Lianhua Qingwen granules combined with oseltamivir (study group, n = 46) for 5 d. After treatment, clinical efficacy and symptom disappearance time (fever disappearance time, cough disappearance time, sore throat disappearance time) were compared between the control and study groups. Changes in immune function [C-reactive protein, interleukin-6, T lymphocyte subsets (CD 4+/CD 8+)] after treatment relative to before treatment, and the incidence of adverse reactions were compared between the two groups. Results:After treatment, total effective rate in the study group was significantly higher than that in the control group [97.83% (45/46) vs. 71.74% (33/46), χ 2 = 12.132, P < 0.001]. Fever disappearance time, cough disappearance time, sore throat disappearance time in the study group were significantly shorter than those in the control group [(2.04 ± 0.51) d vs. (3.15 ± 1.22) d, (3.25 ± 1.10) d vs. (4.53 ± 1.36) d, (2.72 ± 0.84) d vs. (3.95 ± 1.02) d, t = 5.693, 4.963, 6.313, all P < 0.001]. After treatment, C-reactive protein and interleukin-6 levels in the study and control groups were significantly decreased compared with before treatment [(9.24 ± 2.51) mg/L vs. (3.32 ± 2.21) mg/L, (9.21 ± 2.46) mg/L vs. (5.52 ± 2.10) mg/L, (70.25 ± 25.10) mg/L vs. (47.57 ± 14.50) mg/L, (69.24 ± 25.43) mg/L vs. (55.23 ± 16.44) mg/L]. After treatment, C-reactive protein and interleukin-6 levels in the study group were significantly lower than those in the control group ( t = 5.307, 3.138, all P < 0.001). After treatment, the number of CD 4+/CD 8+ cells in the study and control groups was significantly increased compared with before treatment [(0.45 ± 0.21) vs. (1.77 ± 0.59), (0.46 ± 0.18) vs. (1.08 ± 0.42)]. After treatment, the number of CD 4+/CD 8+ cells in the study group was significantly higher than that in the control group ( t = 14.295, 9.202, both P < 0.001). There were no significant differences in the incidence of nausea, vomiting, rash and diarrhea between the two groups within 5 d of treatment (all P > 0.05). Conclusion:Oseltamivir combined with Lianhua Qingwen granules exhibits better therapeutic effect than Lianhua Qingwen granules alone. It can strengthen immune function and shorten the durations of fever, cough and sore throat in patients with influenza.

Objective:To investigate the effects of recombinant human growth hormone on bone metabolism, insulin-like growth factor-1 (IGF-1) and vitamin D3 in dwarfism children at different ages.Methods:Sixty children with dwarfism who received treatment in Shaoxing Women's and Children's Health Care Hospital from January 2018 to January 2019 were included in this study. They were divided into group A (age at 4-9 years, n = 32) and group B (age at >9-13 years, n = 28) according to different ages. Two groups of children were treated with recombinant human growth hormone for 6 months. Total effective rate in two groups was recorded. Before and after treatment, bone metabolism index, serum IGF-1 and 25-hydroxyvitamin D3 levels were measured in each group. Results:Total effective rate in the group A was significantly higher than that in the group B [90.62% (29/32) vs. 67.85% (19/28), χ2 = 4.838, P < 0.05]. Before treatment, there were no significant differences in serum levels of calcium, phosphorus, zinc, IGF-1 and 25 hydroxyvitamin D3 between groups A and B (all P > 0.05). After treatment, serum levels of calcium, phosphorus, zinc, IGF-1 and 25 hydroxyvitamin D3 in the group A were (1.99 ± 0.53) mmol/L, (1.76 ± 0.14 ) mmol/L, (88.97 ± 6.89) μmol/L, (325.57 ± 15.29) ng/L, (89.47 ± 15.58) ng/L, respectively,which were significantly higher than those in the group B [(1.71 ± 0.55) mmol/L, (1.65 ± 0.15) mmol/L, (85.22 ± 6.76) μmol/L, (312.29 ± 13.88) ng/L, (80.11 ± 15.31) ng/L, t = 2.005, 2.936, 2.121, 3.502, 2.340, all P < 0.05]. Conclusion:Recombinant human growth hormone has better curative effect on dwarfism in children at 4-9 years old than in children at 9-13 years old, and it can effectively improve bone metabolism, IGF-1, vitamin D3 and other indicators.

Objective To analyse the relationship between the diagnosis of disseminated intravascular coagulation(DIC) and the level of Thrombomodumin(TM),thrombin-antithrombin(TAT) and D-dimer in plasma from 67 patients with disseminated intravascular coagulation(DIC).Methods The levels of TM,TAT and D-dimer were measured by a two antibody sandwich enzyme linked immunosorbent assay and a latex aggregation assay.Results The levels of TM,TAT and D-dimer in plasma of patients with DIC were higher than those in control group(P

Objective The clinical effect of Allitride as disinfectant in infective root canal of deciduous teeth was studied. Methods 40 teeth were put into the cotton thist with Allitride juice in root canals,sealed by zno for a week. FC CP were used in the contrast groups with consist of 38 teeth. Results The effect of 24 teeth in the Allitride group were excellent, 13 teeth were benign, The efficiency was 92 percent. In CP group, 8 teeth were excellent, 5 teeth were benign, The efficiency was 72 percent. 11 excellent effect and 7 benign effect were in FC group. The efficiency was 90 percent. There are significant difference between Allitrade group and GP group(P0.05). The Allitride effect have not significant relation with age, tooth position.Conclusions Allitride is a good disinfectant adapt to infective root canal of deciduous teeth.

OBJECTIVE:To investigate the value of genetic testing in clopidogrel individualized antiplatelet therapy for acute coronary syndrome(ACS)patients after percutaneous coronary intervention(PCI). METHODS:Clinical pharmacists participated in therapy for 3 ACS patients after PCI,and analyzed risk factors of stent thrombosis as the degree of lesion complexity,length and number of stents,complication,smoking history,etc. Clinical pharmacists suggested conducting clopidogrel genetic testing (CYP2C19,PON1,ACBC1),and suggested replacing antiplatelet agents,maintaining original plan and strengthening monitoring according to the results of genetic testing. RESULTS:The physicians adopted the suggestions of clinical pharmacists. After optimiz-ing antiplatelet therapy according to the results of genetic testing and clinical factors,3 patients were stable and discharged from hospital with drugs. CONCLUSIONS:Genetic testing can provide evidence for the formulation of individualized antiplatelet thera-py in ACS patients after PCI,and can be regarded as one of the breakthrough points for clinical pharmacists to carry out pharmaceu-tical care. In conducting genetic testing,clinical pharmacists should evaluate the risk of thrombosis in ACS patients and select the appropriate population for testing. At the same time,the clinical factors as medication compliance,stent thrombosis risk,therapeu-tic efficacy,ADR,and evidence-based pharmaceutical evidence should be comprehensively evaluated on the basis of genetic test-ing,and antiplatelet therapy plan should be optimized so as to guarantee the safety and effectiveness of drug use.

Correspondence between man and nature theory is the core of TCM chronomedicine, and also plays an important role in ancient Chinese philosophy. The theory believes that distinguishing the rhythm is the foundation of treatment; complying with nature is the core of treatment; taking advantage of wane and wax is the method of treatment. This article combined the physiological and pathological characteristics of children to review the prevention and treatment of pediatric diseases based on chronomedicine, with a purpose to provide inspirations for clinical treatment.