The animal experiments,clinical researches and epidemiological investigations indicated that genistein has the effect for prevention and treatment of osteoporosis,cardiovascular disease and cancer.Genistein can inhibit cellular and humoral immunity and can regulate cell apoptosis.The chemical structure,biological effects and the mechanism of genistein attracted much attention.The current research advance on genistein was summarized and the prospect on the theoretical significance,clinical importance was presented in this paper.

Hypothyroidism is one of the most common endocrine disorders in childbearing or pregnant women.Gestational hypothyroidism can increase the incidence rate of the variety of pregnancy complications and adverse pregnancy outcome.It also can make adverse effects on the fetus and neonate,such as death,placental abruption,fetal malformation,intrauterine growth retardation and preterm,low birth weight,neonatal respiratory distress syndrome,it can also cause abnormal thyroid function of neonate,severely can cause nerve,mental,physical and mental developmental abnormalities and even death.Therefore,it is recommended that childbearing women who are at high risk for pregnancy should strengthen to monitor pregnancy thyroid function and treat as soon as possible in order to reduce the adverse effects on offspring.

OBJECTIVE: To evaluate the current situation and trend of narcotic drug use in our hospital where the authors work in order to provide the reference for scientific management and rational use of these drugs. METHODS: The yearly amount of narcotic drugs administered in the whole hospital, the yearly amount in the separate departments, as well as drug expenditures and ratios between January 2002 and November 2005 were added up and analyzed statistically. RESULTS: The amount of bucinnazine use dominated in the first. The amount of morphine for oral use was increasing year by year. The amount of fentangl transdernal patch use was also bigger and increasing rapidly. However, the amount of pethidine and morphine for injection use was decreasing. CONCLUSION:Analgetics for oral and transdermal use will be the main categories of analgetics in the future.

Metabolic related fatty liver disease(MAFLD) is a kind of fatty liver disease caused by metabolic dysfunction closely related to insulin resistance and genetic susceptibility, also known as nonalcoholic fatty liver disease (NAFLD). Chronic hepatitis C (CHC) is a worldwide curable viral hepatitis caused by hepatitis C virus (HCV) infection.If MAFLD is combined with CHC, CHC can lead to insulin resistance, increase the oxidative stress of hepatocytes, accelerate the steatosis of hepatocytes, and affect the therapeutic effect of MAFLD.

Maternal heart disease has emerged as one of the major diseases threatening pregnant women's safety and long-term cardiovascular health. It is worth noting that there is a large gap in pregnancy prognosis with various cardiovascular diseases. The American College of Obstetricians and Gynecologists (ACOG) has published a practice bulletin named "Pregnancy and Heart Disease" in April 2019, which addressed the prevalence, risk factors, and heart disease effects on pregnancy and the puerperium. It outlined the common types and tiered care recommendations for cardiovascular diseases during pregnancy and puerperium.

Objective To explore the characteristics of TCM syndromes of acute coronary syndrome(ACS). Methods Clinical data of 127 ACS patients were collected and then a database was established.After that,the distribution of syndrome patterns was analyzed.Results The incidences of the following excess syndrome patterns were in a decreasing sequence:stasis syndrome,phlegm syndrome,cold syndrome and heat syndromes.The incidence of stasis syndrome was 90.5%,which was much higher than other excess syndromes.The incidences of the following deficiency syndrome patterns were in a decreasing sequence:heart-Qi deficiency syndrome,heart-Qi exhaustion syndrome,heart-yin deficiency syndrome,heart-Qi depletion syndrome,heart-kidney deficiency syndrome and heart-blood deficiency syndrome.The incidence of heart-Qi deficiency syndrome was 75.6%,which was much higher than other deficiency syndromes.The incidences of the stasis syndrome and cold syndrome in acute myocardial infarction(AMI)were higher than those in unstable angina(UA),and the incidences of heart-Qi deficiency syndrome and heart-Qi exhaustion syndrome in AMI were higher than those in UA(P

Objective To describe the citations of non-experimentsl nursing research papers in China,to reflex the academic level of non-experimental nursing research papers and the utilization of reseachers to literature information. Methods 2547 non-experimental nursing research papers were manually searched out from 466 issues of two kinds of core nursing journals named Chinese Journal of Nursing and Journal of Practical Nursing (which was changed to Chinese Journal of Practical Nursing in 2003) from 1990 to 2006,bibliometric analysis was used to analyze their citations from quantities, price indicator, sorts, resources and languages. Results The quantity of citations per paper was 4.4, which increased over time; the Price indicator was 55.6%; citations to journal predominated(73.4%) and there was a growing trend over time; most citations were to medical journals outside the profession of nursing (59.1%), while citations to nursing increased gradually; Chinese (73.6%) was the language of most of the citations, while the percentage of English citations increased gradually. Conclusions The competence of absorbing information of researchers in China was gradually increasing, their competence of absorbing foreign information needs to be strengthened urgently.

Nano-hydroxyapatite biomimetic bone materials have become a hotspot in the field of tissue engineering research due to the similarity of the structure and composition to natural bone. This article describes a variety of preparation of nano-hydroxyapatite and synthesis of nano-hydroxyapatite composite, as well as the properties of nano-hydroxyapatite composite materials. Through surface-modification nanohydroxyapatite composite materials will have a potential application foreground including bone defects repair,drug carrier for cancer treatment. In this paper, research progress of nano-hydroxyapatite biomimetic bone materials in recent years were reviewed.

s:Primary chronic intestinal pseudo-obstruction (PCIPO)is a rare digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases. This article is aimed at reviewing the current knowledge on etiology, clinical features and management of patients affected by PCIPO.

Pancreatic cancer has a strong ability of invasive and metastasis,and the mechanism is still not completely clear.It has been demonstrated that aberrant expression of microRNAs(miRNA) is closely associated with the occurrence,development and metastasis of pancreatic cancer.The reveal of miRNA mechanism related to the metastasis of pancreatic cancer would provide a new approach to the treatment of pancreatic cancer.