Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Drug Delivery Systems ; methods ; Drug Resistance, Neoplasm ; Humans ; Mutation ; Neoplasms ; drug therapy ; genetics ; pathology

Acquired Immunodeficiency Syndrome ; diagnosis ; pathology ; Alzheimer Disease ; diagnosis ; pathology ; Autopsy ; Diagnosis, Differential ; Hepatitis, Viral, Human ; diagnosis ; pathology ; Humans ; Idiopathic Interstitial Pneumonias ; diagnosis ; pathology ; Neoplasms ; diagnosis ; pathology ; Pathology, Molecular ; methods ; Staining and Labeling

Breast Neoplasms ; drug therapy ; genetics ; pathology ; Carcinoma, Ductal, Breast ; drug therapy ; genetics ; pathology ; Carcinoma, Lobular ; drug therapy ; genetics ; pathology ; Cell Nucleus ; pathology ; Female ; Gene Expression Profiling ; Humans ; Immunophenotyping ; Lymphatic Metastasis ; Lymphatic Vessels ; pathology ; Neoadjuvant Therapy ; Tumor Burden

Biomarkers, Tumor ; analysis ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Irritable Bowel Syndrome ; pathology ; Lymphoma, B-Cell ; pathology ; Oncogene Proteins, Fusion ; analysis ; Sarcoma, Synovial ; chemistry ; pathology

Biomarkers, Tumor ; genetics ; metabolism ; Humans ; Molecular Targeted Therapy ; standards ; Mutation ; Neoplasms ; drug therapy ; genetics ; metabolism ; pathology

Autopsy ; China ; Diagnosis, Differential ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Pathology ; manpower ; organization & administration ; standards ; Practice Guidelines as Topic ; Quality Control

Chromogranin A ; metabolism ; Gastrointestinal Neoplasms ; classification ; metabolism ; pathology ; Humans ; Immunohistochemistry ; Neuroendocrine Tumors ; classification ; metabolism ; pathology ; Pancreatic Neoplasms ; classification ; metabolism ; pathology ; Pathology ; standards ; Synaptophysin ; metabolism ; World Health Organization

Autopsy ; Biopsy ; Pathology ; education ; Pathology Department, Hospital ; organization & administration ; Pathology, Surgical ; methods ; Quality Control

ObjectiveTo study the effect of 8-Br-cAMP and isopentenyl pyrophosphate (IPP) on the ex pression tau protein in various neural cell lines at the level of signal transdu ction. MethodsNG108-15, PC12 and SH-SY5Y cells were treated with 8-Br-cAMP and IPP in the 37?C incubator for 30 min, then the tau-enriched samples were analyzed by West ern blot. ResultsSH-SY5Y cells only expressed the isoform of tau protein with the lowest molecul ar weight; PC12 cells mainly expressed high molecular weight tau, and several ot her isoforms of tau; NG108-15 expressed a little of isoform of tau. In the expe rimental conditions, the expression of tau was altered with 8-Br-cAMP and IPP in NG108-15, SH-SY5Y and PC12 cells. Conclusions8-Br-cAMP and IPP does not alter the expression of tau in NG108-15, SH-SY5Y and PC12 cells.

In view of the problems existing in the physiatry teaching of rehabilitation therapy specialty, the characteristics of the work-shop mode, which is a kind of teaching mode popularized in domestic and international higher education, was analyzed. The workshop mode was introduced into the practical teaching of physiatry, and the main organization form of practical teaching was put forward and put into practice. The results showed that the workshop mode improved the students' abilities of practice, self learning, expression, interpersonal communication and innovative consciousness, etc.