Objective To assess whether lysyl oxidase like-2 (LOXL2) has a predictive or prognostic value in pulmonary fibrosis mice,and identify the relationship between LOXL2 and transforming growth factor (TGF)-β 1.Methods Male C57BL/6 mice (n=50) were randomly divided into the experimental group (n=40) and controls (n=10).Each mouse in the experimental group was induced by injecting bleomycin into trachea and mice were sacrificed on day 3,7,14 and 28,respectively.The concentrations of LOXL2,TGF-β 1 of the serum and lung homogenates were measured by enzyme-linked immunosorbent assay.One-factor analysis of variance (ANOVA) and nonparametric rank sum test was used for the comparisons between the two groups.Associations between these factors were analyzed by Spearman's test.Results ① The levels of serum and lung homogenates LOXL2 in the experimental group were obviously increased as compared to those in the controls [serum:(56±48) vs (25±23),P＜0.05;lung homogenates:(61±32) vs (22±16),P＜0.05].And in the experimental group,a positive correlation was found between the level of LOXL2 and the radiological index,the pathological score of inflammation and fibrosis.(Serum:r=0.435,0.533,0.335,P＜0.05;lung homogenates:0.675,0.736,0.526,P＜0.05).② The levels of lung homogenates TGF-β 1 in the experimental group were obviously increased as compared to those in the controls [(302±197) vs (64±16),P＜0.05].A positive correlation was found between the level of lung homogenates LOXL2 and the level of lung homogenates TGF-β1 (r=0.520,P＜0.05).Conclusion LOXL2 participates in the pathological process of bleomycin induced pulmonary fibrosis in mice.It predicts pulmonary fibrosis in the preclinical stage and is associated with increased risk for disease progression.The elevated levels of LOXL2 and TGF-β 1 may have some relationship.They both are involved in the disease progression of pulmonary fibrosis.

The pffect of 5 drugs on myocardial nutritional blood flow of micehave been determined with ~(86)Rb. It was shown that the root of xanthiumsibiricam, caesulpinia sepiaria and the branch of cinnamomum cassia couldincrease myocardial nutritional blood flow in mice The Pharmacologicalactions of these drugs have heen reviewed briefly.

0.05). ② Significantly positive correlation was found between serum testosterone and fasting insulin (r=0.693, P

Objective To study the serum lipid(TC,TG,LDL-C) and the role of typeⅠcollagen,NF-?B,typeⅠcollagen mRNA and NF-?B mRNA levels and their mechanisms in the occurrence and progress of atherosclerosis in order to provide theoretical gist for its prevention.Methods Blood vessel wall pathological and the serum lipid changes,the expressions of typeⅠcollagen,NF-?B,typeⅠcollagen mRNA and NF-?B mRNA levels were observed in dietary induced atherosclerosis rabbit model by morphology study,immunohistochemistry,in situ hybridization technique and color image analyzer(CMAIS).Results The model of AS was established successfully after rabbits were fed with cholesterol,who developed the fatty streak lesion in the aortic intra-wall.In the rabbit model,TC and LDL were respectively increased 43 times and 37 times and there were no difference in TG and body weight.Type I collagen,NF-?B,type I collagen mRNA and NF-?B mRNA were 0.27?0.02,0.19?(0.01) and 0.30?0.03,0.35?0.03,respectively,which were higher than those of control group(0.08?0.01,0.09?0.01 and 0.11?0.01,0.10?0.09,respectively)(P

Adult ; Biomarkers, Tumor ; metabolism ; Epididymis ; metabolism ; pathology ; surgery ; Humans ; Inhibins ; metabolism ; Leydig Cell Tumor ; metabolism ; pathology ; surgery ; Male ; Testicular Neoplasms ; metabolism ; pathology ; surgery ; Vimentin ; metabolism

Objective: The purpose of the current study was to investigate the correction coefficient of the characterizations of multi-detector CT (MDCT). Methods: The dose profile of Siemens SOMATOM Definition Flash CT scanner was measured with CT-SD 16 detector under the conditions of different collimations, pitches and tube voltages in phantoms of different diameters, and the ratio between weighted CTDI∞and weighted CTDI100 was calculated. Results:The ratio between weighted CTDI∞and weighted CTDI100, which is growing for increasing beam collimation, was found to range from 1.123 to 1.162 in head phantom and range from 1.118 to 1.173 in body phantom. Conclusion: For MDCT, the use of CTDI100, which is one of the most commonly used characterizations of CT, has always underestimated the levels of radiation dose. Therefore, CTDI100 should be corrected.

Objective:To correct the characterizations of MDCT radiation dose by exploring the relationship between CTDIw,∞ and CTDIw.Methods: CTDI100 and CTDI∞ were measured under the conditions of different collimations, pitches and tube voltages of Siemens Definition Flash CT, and CTDIw and CTDIw,∞ were calculated.Results: There were significant differences between CTDIw and CTDIw,∞ which were measured at 0.05 level. And there were no significant differences between CTDIw,∞ after corrected and CTDIw,∞ which were measured at 0.05 level.Conclusion:The characterizations of MDCT which were commonly used were not accurate enough. The result after correction were very closed to the real CTDIw,∞. This showed that the method to correct CTDIw of Siemens Definition Flash CT was mostly accurate. And methods to correct CTDIw of other MDCT needed to be further studied.

[Summary] In this case report , a 44-year-old female patient complained of three years of tightness and chest pain , and was hospitalized in January 2016.The thymus and tumor were completely resected under video-assisted thoracoscopic surgery (VATS). Postoperative pathological examination presented a thymic mucoepidermoid carcinoma .The patient received 30 times of chemotherapy after operation and were followed up for 2 months.Postoperative recovery was smooth without symptoms .The CT scanning showed negative result .We consider that VATS was feasible and safe for the treatment of thymic carcinoma .

Objective:To compare the effect of four different techniques on removal of vapor lock in the apical region of curved root canals.Methods:Forty simulated resin root canals with 45° curvature were prepared using WaveOne Primary,then the apical foramen were sealed with soft wax.The teeth were divided randomly into 4 groups thereafter (n =10).Contract solution was injected into the canals using a 30 G side-vented needle and scanned with cone-beam CT (CBCT) to identify the volume of the vapor lock.Four different techniques including photon-induced photoacoustic streaming (PIPS) laser-activated irrigation,gutta-percha cone technique,ultrasonic irrigation,and sonic irrigation were used to remove the vapor locks in the root canals.The residual volume of the vapor lock was identified again using CBCT scanning data.Accordingly,the reduction rates of the vapor lock were calculated.Furthermore,the initial and residual vapor lock length was calculated.The data were analyzed by using the One-Way ANOVA analysis and Kruskal-Wallis H test at a significance level of P ＜ 0.05.Results:There was no significant difference in the initial vapor lock volume (P ＞ 0.05).Residual volume of the vapor lock for PIPS laser-activated irrigation was 0 mm3,and that for gutta-percha cone technique was (0.02 ± 0.07) mm3,significantly lower than those of ultrasonic and sonic irrigation,the values being (0.20 ± 0.09)mm3 and (0.23 ±0.06) mm3 (P ＜0.001),respectively.The reduction rates of the vapor lock of PIPS laser-activated irrigation and gutta-percha cone technique were 100.00％ (100.00％,100.00％) and 100.00％ (77.66％,100.00％),respectively,significantly higher than those of ultrasonic irrigation [70.37％ (56.41％,91.43％)] and sonic irrigation [63.54％ (51.47％,74.00％),P ＜0.001].The length of the residual vapor lock for PIPS laser-activated irrigation was 0 mm,and that for gutta-percha cone technique was (0.15 ±0.47) mm,significantly lower than those of ultrasonic and sonic irrigation,values being (2.21 ±0.09) mm and (2.34 ±0.08) mm (P ＜0.001),respectively.The length of the residual vapor locks in the ultrasonic and sonic group remained approximately the same as the distance between the working tip and the apical foramen.Conclusion:PIPS laser activated irrigation and gutta-percha cone technique could remove the vapor lock from the apical region of curved canals effectivelv.

OBJECTIVE:To probe into a feasible work mode for special clinical pharmacist of hypertension.METHODS:Clinical pharmacists' works were summarized by considering the experience of clinical pharmacists and examples of pharmaceutical care in hypertension wards.RESULTS&CONCLUSIONS:Special pharmacists of hypertension should participate in clinical treatment team,check prescription every day and acquaintance with status quo of patients' medication so as to carry out pharmaceutical care suitability.It also should find out and resolve situation of ADR in time and master the characteristics of hypertension.