Hypersensitivity reactions ( HSRs) are the serious problems of taxanes in the clinical appli- cation. These reactions range in severity from mild flushing and itching to bronchospasm, dyspnea and signifi-cant alterations in blood pressure with loss of consciousness or not, and death in some rare cases. Nevertheless, HSRs are often reported only sporadically in clinical trials or as case reports. The vague or inconsistent termi-nology used to describe these reactions may reflect our poor understanding of their pathophysiology. This article will reviews the advancement of taxanes HSRs.

Processed by the MATLAB-based wavelet analysis,normal EEG signal is used as stimulating source to stimulate brain at proper points for insomnia treatment.This paper explains the design principle of the instrument as well as the hardware structure and the software implementation.

Objective To measure the course of the mandibular canal in mandibula posterior area by cone-beam computed tomography ( CBCT ) , to provide a theoretical support for implant preoperative assessment. Methods Mandibular data of 65 people measured by CBCT were collected, measured the distance between mandibular canal around the bone wall and analyzed the differences by gender and the differences between the left and the right. Results The average distance of mandibular canal outer edge to the buccal bone plate by former backward in-creased gradually,at least in the area of the mental formen, at largest in the area of the mental foramen after 18 mm. The average distance between mandibular canal inner edge to lingual bone plate by former backward reduced gradually, at largest in the area of the mental foramen,at least in the area of the mental foramen after 18 mm. The average distance between mandibular canal upper edge to alveolar crest by former backward reduced gradually,at largest in the area of the mental foramen, at least in the area of the mental foramen after 18 mm. The average dis-tance between the edge of mandibular canal to the edge of mandible by former backward reduced previous,then in-creased, at least in the area of the mental foramen after 6 mm, at largest in the area of the mental foramen after 18 mm. All the results had no significant statistical differences between the male and the female, and had no significant statistical differences between the left and the right. Conclusion The trajectory of the mandibular canal from front to back is downward first, then upward in the mesial of the first molar in the vertical, and whose from the buccal side to the lingual side. That has significance for assessment before implant in mandibular posterior area.

Objective To know the health habit about water drinking of the residents in the communities provided with pipe direct drinking water system. Methods From June, 2006 till July, 2006, 340 family were interviewed using the same questionnaire. At the same time, the water samples were collected from the pipe direct drinking water system and tap water. Results Of the interviewed family, 80.37% drank the water of pipe direct drinking water system. 47.66% also used the water for washing, gargling, cooking and so on. 61.69% drank the water without boiling. 69.15% did not abandon the old water before using. 67.29% never sterilized the tap and the detection rate of bacteria in the samples was 83.18%. Conclusion The contamination situation of the pipe direct drinking water system in Podong New District, Shanghai is not to be ignored. The health administrative organization must strengthen the inspection of the pipe direct drinking water system and the health education in this field must be promoted.

Medical equipment is playing an important role in medical treatment, teaching and scientific research, especially in how to improve the utilization rate of large and middle medical equipment to ensure the safety and integrity of medical equipment in the clinical operation, and this is a very significant job. Through the operation of large and middle medical equipment to conduct analysis, comparison and statistics, it can be found the issue and adjusts timely to improve the medical equipment management of the technological level and economic benefits.

To discuss the advantages and disadvantages of fibular osteosynthesis and osteotomy in the treatment of tibial fractures. Medical literature was searched for articles concerning “fibular fracture”and“fibular osteotomy”on Medline to have a comprehensive idea of experiences of others. The results of others and of ours were analyzed and interpreted. Fractures of distal tibia and fibula with displaced distal tibial articular fractures were classic indications of fibular osteosynthesis, but distal tibiofibular syndesmosis and stability of ankle joint were seldom affected by the fibular fracture when tibia was fractured. It is not necessary to perform routine osteosynthesis for distal fibula fracture. Fibular osteotomy may be considered as an adjuvant procedure when atrophic nonunion or deformity union of tibia occurs. It is wise in treatment of tibial fractures not to perform fibular osteosynthesis or osteotomy whenever possible.

Objective To detect the expression of apoptotic inhibitor protein Livin in different esophageal epithelial lesions and to analyze the relation between the expression of Livin with pathologic characteristics. Methods The expressions of Livin mRNA and Livin protein were detected by real- time fluorescence quantitative PCR and western blot in 40 patients with different esophageal epithelial lesions including normal, atypical hyperplasia, carcino-ma in stiu and invasive carcinoma. Results The expressions of Livin mRNA were progressively increased from nor-mal to invasive carcinoma( 1.00 ± 0. 00,2.26 ± 0.79,7.24 ± 1.06,12.21 ± 2.47 ). There was statistical signifi-cance in Livin mRNA expression among carcinoma in stiu and invasive carcinoma and normal tissues ( P < 0.05 ). Conclusion The expression of Livin is significantly related to the progression of esophageal cancer,which may be a new target for diagnosis and gene treatment of esophageal carcinoma.

Human Dermatoglyphics is elective in the Shanghai Jiaotong University, which is popular among the students. The 284 anonymous questionaires were received and the result was analyzed. Based on the teaching practice of human dermatoglyphic the opinions about the teaching reform and curriculum construction have been made in this paper.

The author proposed student-centered learning system in otolaryngology-head and neck surgery for undergraduate clinical training after exploration and intentions.Four mutual impacted frames were built including integration of teaching philosophy,visualization of training methods,diversification of educational targets and interaction of training courses.Endoscopic navigated learning and multimedia aided training were applied,respective teaching purposes were set and various clinical training courses were introduced to students in their learning of otolaryngology,which were believed to help develop more medical talents with higher comprehensive qualities and better clinical skills.

Objective To observe the effects of dynamic pressure for the ability of endothelial progenitor cells (EPCs) to form blood vessels, when EPCs seeded into DBM with load. Methods Use the Ficoll density gradient centrifuge combined with difference-speed adherence screening method to separate MNCs from rat bone marrow. Identify the induced EPCs by means of immunohistochemistry and immunofluorescence. Through the organization of fixed, defatted, decalcified and other steps use of spine vertebral body,demineralized bone matrix (DBM) samples of pig were prepared in vitro. Divided scaffolds into two groups A and groups B. Induced EPCs were seeded into DBM. The cell-seeded scaffolds of groups A were dynamically loaded in compression using a sine wave at 1 Hz, 5% strain in the media-filled chamber for 4 h on days 5 of culture. and cell-seeded scaffolds of groups B were cultured directly without any load. Both of two groups were cultured two weeks. Then the ability of EPCs to form blood vessels was observed. Primer desig;Extract total RNA from cells with Trlzol; Reverse transcription reaction; PCR. Results Two groups of cells in HE staining and fluorescent staining showed the formation of vascular bundles. There were formation of blood vessels. It was obvious that the formation in group A was more than that in group B. Test the mRNA expression of vWF and Flk-1 during the EPCs differentiationby RT-PCR. Group A was significantly stronger than that of group B. Conclusion When DBM combines together with EPC, it has become organization engineering bone, then with press on it, the bone graft has been vascularized, so it has clinical application on the direction of repair bone defect.