Objective To disclose the implication of nuclear transcription factor(NF)-?B and interleukin(IL-8) in the angiogenesis and prognosis of gastric cancer. Methods The expressions of NF-?B, IL-8 and microvessel density (MVD) in 41 samples of gastric cancer were detected by immunohistochemistry. Results NF-?B and IL-8 were positive in 28 samples (68.3%) and 12 samples (29.3%) respectively. NF-?B, but not IL-8, was related to MVD significantly( P =0.002), and there was significant relationship between the expressions of NF-?B and IL-8 and TNM staging( P