1.Bloodletting combined with medicinal cupping and moxibustion for 36 cases of insect bite dermatitis with lymphangitis.
Liyan ZHAO ; ZHEN WEN ; Xinxin HUANG
Chinese Acupuncture & Moxibustion 2016;36(1):57-58
Adolescent
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Adult
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Aged
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Bloodletting
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Child
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Child, Preschool
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Combined Modality Therapy
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Dermatitis
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therapy
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Female
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Humans
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Infant
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Insect Bites and Stings
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therapy
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Lymphangitis
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therapy
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Male
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Middle Aged
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Moxibustion
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Young Adult
2.Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors.
Wen LUO ; Yongmei ZHAO ; Zhen ZHANG ; Yabin SU ; Chaojie WANG
Acta Pharmaceutica Sinica 2012;47(7):916-21
A series of tacrine-methoxybenzene hybrids (5a-5i) were designed, synthesized and evaluated as inhibitors of cholinesterases (ChEs). All the compounds had better ChEs inhibitory activities than tacrine with IC50 values at the nanomolar range. Compound 5h exhibited the strongest inhibition on acetylcholinesterase (AChE) with an IC50 value of 6.74 nmol x L(-1) and compound 5f showed the most potent inhibition on butyrylcholinesterase with IC50 value of 3.83 nmol x L(-1). Kinetic and molecular modeling studies showed that these hybrids targeted both the catalytic active site and the peripheral anionic site of AChE.
3.Optimization of extraction technology for salidroside, tyrosol, crenulatin and gallic acid in Rhodiolae Crenulatae Radix et Rhizoma with orthogonal test.
Xin LUO ; Xue-jing WANG ; Yi-wu ZHAO ; Wen-zhe HUANG ; Zhen-zhong WANG ; Wei XIAO
China Journal of Chinese Materia Medica 2015;40(18):3590-3593
The extracting technology of salidroside, tyrosol, crenulatin and gallic acid from Rhodiolae Crenulatae Radix et Rhizoma was optimized. With extraction rate of salidroside, tyrosol, crenulatin and gallic acid as indexes, orthogonal test was used to evaluate effect of 4 factors on extracting technology, including concentration of solvent, the dosage of solvent, duration of extraction, and frequency of extraction. The results showed that, the best extracting technology was to extract in 70% alcohol with 8 times the weight of herbal medicine for 2 times, with 3 hours once. High extraction rate of salidroside, tyrosol, crenulatin and gallic acid were obtained with the present technology. The extracting technology was stable and feasible with high extraction rate of four compounds from Rhodiolae Crenulatae Radix et Rhizoma, it was suitable for industrial production.
Chemical Fractionation
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methods
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Chemistry, Pharmaceutical
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methods
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Coumarins
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isolation & purification
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Drugs, Chinese Herbal
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isolation & purification
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Gallic Acid
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isolation & purification
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Glucosides
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isolation & purification
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Phenols
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isolation & purification
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Phenylethyl Alcohol
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analogs & derivatives
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isolation & purification
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Rhizome
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chemistry
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Rhodiola
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chemistry
4.Application of social network analysis in domestic medical and health field and its enlightenments
Xia MA ; Tianmin ZHEN ; Jingliang GU ; Fang ZHAO ; Jingli LI ; Zhiyan HAN ; Weijie DOU ; Nan WEN
Chinese Journal of Medical Library and Information Science 2014;(10):18-21
Social network analysis has been a study hot spot in academic circle in recent years and is applied in several fields.After a brief description of its basic theories and study methods, its application in domestic medical and health field were analyzed with its key study hot spots summarized and its problems pointed out, in order to provide the methods that can learned in domestic medical and health studies.
5.3521 project-based master design of regional health information construction framework
Zhiyan HAN ; Tianmin ZHEN ; Jingliang GU ; Fang ZHAO ; Weijie DOU ; Nan WEN ; Jingli LI ; Xia MA
Chinese Journal of Medical Library and Information Science 2014;(3):19-22
The functional framework of information management system for regional medical and health institutions was established according to the 5 application systems (public health, medical service, medical support, drug supply support and general management ) and the target to develop 2 databases ( a resident electronic health records data-base and a resident electronic medical records database ) and an operational network put forward in the overall framework of health information construction during The National Twelfth-5 Year Plan Period, based on the functional position of health institutions at different levels.The difficulties to realize the target of the national 3521 project and its prospects were pointed out.
6.Chemical constituents of Euphorbia dracunculoides.
Li WANG ; Ming-Ming YU ; Yu-Qian CHI ; Wen-Bin OUYANG ; Zhen ZANG ; Yong ZHAO
China Journal of Chinese Materia Medica 2014;39(20):3969-3973
Sixteen compounds including daphnoretin (1), isofraxidin (2), scopoletin (3), kaempferol (4), quercetin (5), guaijaverin (6), astragalin (7), quercetin-3-O-β-D-glucopyranoside (8), naringenin-7-O-β-D-glucopyranoside (9), 5-O-methylapi- genin-7-O-β-D-glucopyranoside (10), methyl gallate (11), prionitiside A (12), (2S)-2,3-dihydroxypropyl-1,6,8-trihydroxy-3- methyl-9,10- dioxoanthracene-2-carboxylate (13), 3,3'-di-O-methyl ellagic acid (14), 3'-O-methyl-3,4-O,O-metheneellagic acid-4'-O-β-D- glucopyranoside (15) and 3,4-methylenedioxy-3'-O-methylellagic acid (16), were isolated from the 70% acetone extract of Euphorbia dracunculoides Lam. Among them, compounds 1-3, 6-9, 11, and 14 were isolated from E. dracunculoides for the first time, and compounds 10, 12, 13, 15, and 16 were firstly obtained from the genus Euphorbia. Their structures were elucidated by spectroscopic analysis, including 1H-NMR, 13C-NMR, and ESI-MS.
Drugs, Chinese Herbal
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chemistry
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isolation & purification
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Euphorbia
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chemistry
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Molecular Structure
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Plant Leaves
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chemistry
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Plant Stems
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chemistry
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Spectrometry, Mass, Electrospray Ionization
7.The diagnostic value of endoscopic ultrasonography guided fine needle aspiration for occupying pancreatic lesions
Zhen FAN ; Le ZHANG ; Xiaofeng ZHANG ; Ping HUANG ; Wen LYU ; Xia WANG ; Youan ZHAO
Chinese Journal of Digestive Endoscopy 2016;33(12):847-850
Objective To evaluate safety and efficacy of EUS-FNA for occupying pancreatic lesions.Methods Data of 62 patients with occupying pancreatic lesions,who underwent EUS-FNA between June 2011 and June 2014,were analyzed for completion and complications,with surgery and clinical follow-up as the golden standard.Accuracy,sensitivity and specificity of EUS-FNA were calculated.Results A total of 62 patients with pancreatic lesions successfully underwent EUS-FNA and median puncture number was 4.2(3 to 8).Success rate of puncture was 100% and sampling satisfaction rate was 90.3% (56/62).No complications such as fever,infection,bleeding,perforation,severe pancreatitis or death were found.With the final diagnosis as the golden standard(39 malignant lesions and 23 benign lesions),overall diagnostic accuracy of EUS-FNA was 88.7%(55/62).The cytology diagnostic accuracy was 69.4% (43/62),significantly higher than that of the tissue pathology of 30.6% (19/62,P<0.01).Sensitivity and specificity of the procedure were 87.2%(34/39) and 91.3%(21/23) respectively.Conclusion EUS-FNA is an effective and safe procedure in diagnosis of occupying pancreatic lesions.
8.Nosocomial Infection in Patients with Chronic Kidney Disease:Its Characteristics and Risk Factors
Min YU ; Bing HAN ; Yaoxun SHI ; Xiaoling LIU ; Wei ZHAO ; Na WEN ; Zhen ZENG
Chinese Journal of Nosocomiology 2006;0(09):-
OBJECTIVE To discuss the characteristics and risk factors of nosocomial infection inpatients with chronic kidney disease.METHODS The data from chronic kidney disease(CKD) patients retrospectively analyzed.RESULTS The nosocomial infection rate of CKD patients was 14.73%,urinary tract was the most comun site,The main-pathogens were Gram-negative bacteria,and then Gram-positive bacteria and fungii.The patients with diabetic nephropathy,lupus nephritis,aging,lower glomerular filtration rate,hypoproteinemia,anemia,and long time duration were easy to get nosocomial infection.CONCLUSIONS Nosocomial infection in CKD patients is related to underlying diseases,age,kidney function,serum albumin level,hemoglobin level,duration time in the hospital.
9.SoLoMo-based mobile service in libraries of medical colleges and universities
Jingli LI ; Tianmin ZHEN ; Fang ZHAO ; Jingliang GU ; Weijie DOU ; Xia MA ; Zhiyan HAN ; Nan WEN
Chinese Journal of Medical Library and Information Science 2014;(10):30-32,43
Mobile service in libraries of domestic medical colleges and universities was investigated.The specific characteristics of specialized courses offered in medical colleges and universities, the special nature of medical sub-jects, and the unique features of medical library users were described with suggestions put forward for expanding the mobile service in libraries of domestic medical colleges and universities.
10.Biliary-pancreatic double stents for pancreatic cancer with obstructive jaundice
Zhen FAN ; Xiaofeng ZHANG ; Xiao ZHANG ; Wen Lü ; Yinghui GUO ; Qingfeng YUAN ; Youan ZHAO
Chinese Journal of Digestive Endoscopy 2013;(4):181-184
Objective To analysis the clinical effects of biliary-pancreatic double stents in pancreatic cancer patients with obstructive jaundice.Methods From July 2008 to October 2011,a total of 60 patients with advanced pancreatic cancer were randomly divided into two groups to receive biliary-pancreatic double stents (n =28) or biliary stent only (n =32) according to the odd and even numbers of their admission date.Changes in liver function,abdominal pain,quality of life scores (QOL) were compared between two groups.Results The stents were placed successfully in 54 patients (90.0%),in which symptoms were relieved or gradually disappeared in all patients after the procedure.One week after stents placement,the serum total bilirubin decreased significantly from 164.32 ±45.16 μmol/L before ERCP to 63.25 ±27.06 μmol/L (P < 0.05),other parameters including ALT,AST,AKP and r-GT were also decreased significantly compared with those of pre-ERCP (P < 0.01),but there was no significant difference between the two groups (P > 0.05).25 cases in double-stents group and 29 cases in single-stent group had varying degrees of pain relief at 7d after ERCP,but the overall pain relief rate and complete pain relief rate in double-stent group were significantly higher than those in single-stent group (92.0% vs.55.2%; 64.0% vs.34.5%,P<0.05).At 7d and 14d after ERCP,Karnofsky QOL score were improved significantly in double-stent group (P < 0.05).It was significantly better than single-stent group at 14d after ERCP (P <0.05).No death or other severe ERCP-related complications were observed.Conclusion Biliary-pancreatic stent placement for pancreatic cancer could significantly improve liver function and relieve obstructive pain.In the ways of alleviating pain and improving quality of life scores,it was better than ERCP biliary stent placement,especially for patients with pancreatic cancer combined obstructive pain.It indicated that biliary-pancreatic stent placement was better than simple biliary stent placement for advanced pancreatic head cancer patients with obstructive pain.