2.The analysis of the relationship between the clinical effect,pathological changes and the neoadjuvant chemotherapy containing THP and docetaxel on breast cancer
Hong-Zhen QIN ; Xi-Ru LI ; Yan-Jun ZHANG ; Yi-Qiong ZHENG ; Rong LI ;
China Oncology 2006;0(11):-
Background and purpose:Neoadjuvant chemotherapy is one of the hot studied area in breast cancer research.Our aim was to explore the relationship between the clinical effect,pathological changes and the neoadjuvant chemotherapy containing THP and docetaxel on breast cancer.Methods:The expression of ER, PR and CerbB-2 in breast cancer tissue of patients who had received neoadjuvant chemotherapy were detected by immunohistochemistry method.The relationship of age,ER,PR,CerbB-2,pathological stage and axillary lymph node metastasis with pathological complete response(pCR) was analysed.Results:For the patients after neoadjuvant chemotherapy,the pCR of the positive ER(0%),PR(9.38%) was lower than that of negative ER(20.27),PR(90.63%) respectively.The pCR of the positive CerbB-2(33.33%) was higher than that of negative CerbB-2(9.74%,P
3.Qualitative research on psychological procedure of the family member of patients undergoing renal transplantation
Qiong-Qiong LI ; Zhi-Fei HU ; Jing ZHANG ; Qin XU ; Zhen-Zhen JIN ; Xiao-Jing CHANG ; Hong-Xu CHI
Chinese Journal of Modern Nursing 2011;17(8):884-887
Objective To find out and describe the feeling of the family members who wag taking care of the patients undergoing renal transplantation in order to provide proper psychological support by medical professionals.Methods 11 family members were interviewed by opened questionnaires,and the data were collected and analyzed.Results The data of characteristic feeling and pressure were obtained from family numbers.Conclusions There is a need for extensive and persistent support to the family members,and the nurses should take characteristic nursing measures to help and guide the patients and their family members in order to improve the life quality.
4.Relationship between CD36 expression, foamy cell aggregates in renal interstitium and serum cholesterol level.
Hua SU ; Hong-yan ZHU ; Jian-she LIU ; An-guo DENG ; Zhen-qiong LI
Chinese Journal of Pathology 2011;40(1):42-43
CD36 Antigens
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metabolism
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Cell Aggregation
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Cholesterol
;
blood
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Foam Cells
;
pathology
;
Glomerulonephritis, IGA
;
blood
;
metabolism
;
pathology
;
Glomerulonephritis, Membranoproliferative
;
blood
;
metabolism
;
pathology
;
Glomerulonephritis, Membranous
;
blood
;
metabolism
;
pathology
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Glomerulosclerosis, Focal Segmental
;
blood
;
metabolism
;
pathology
;
Humans
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Nephritis
;
blood
;
metabolism
;
pathology
;
Nephritis, Hereditary
;
blood
;
metabolism
;
pathology
5.Effect and mechanism of TGF-β1/smad3 signal pathways on apoptosis during mice pulmonary fibrosis
Qiong BAI ; Xuejun LIU ; Zhen QIN ; Yufeng DU ; Li QIAN ; Xiaoyan HAO
Chinese Journal of Geriatrics 2014;33(7):802-806
Objective To explore the effect and mechanism of TGF beta1/smad3 signaling pathways on apoptosis in mouse pulmonary fibrosis.Methods Fifty-four healthy male C57BL/6 mice were randomly divided into three groups:normal control (n=18),pulmonary fibrosis model (n =18) and TGF-β1/smad3 inhibitor group (n=18).Six mice in each group were randomly killed on days 7,14 and 28.Hematoxyli~eosin and Masson staining were adopted to evaluate the severity of pulmonary inflammation and fibrosis.The content of hydroxyproline (Hyp) in the lung tissues was detected by alkaline hydrolysis technique.The apoptosis was observed by tunnel apoptosis assay kit.P-smad3 and caspase3 protein expressions were assessed via Western blot.Results Lung in model mice versus normal control showed alveolar inflammatory change in 7 days and significant pulmonary fibrosis in 28 days(P<0.05).Meanwhile,apoptosis index,hydroxyproline content,caspase3,and phosphorylated Smad3 were obviously higher in model mice than in control group (P < 0.05).Compared with model group,TGF-β1/smad3 inhibitor group showed that alveolitis and pulmonary fibrosis degree,hydroxyproline content,cell apoptosis index,the expressions of p-smad3 and caspase3 were decreased at same time point (P < 0.05).Conclusions TGF beta1/smad3 signaling pathways may participate the abnormal apoptosis during the development of pulmonary fibrosis,and TGF-β1/smad3 inhibitor SB431542 could inhibit this process.
6.Study on the Equity of Health Human Resource Allocation in Public Hospitals of Zhaotong City
Ying CHEN ; Qiong MENG ; Lifeng XIONG ; Liping HE ; Zhen YU ; Xiaomei LI
Journal of Kunming Medical University 2016;37(7):14-18
Objective To analyze the equity of health human resource allocation in public hospitals of Zhaotong city during 2008-2012,and to provide theoretical basis for the reasonable allocation of health resources.Methods The statistical description was used to analyze the number of the medical health resource,and Gini coefficient and Theli index were used to analyze the equity of health resource allocation in public hospitals of Zhaotong city.Results The amount of medical health resource showed an increasing tendency with low speed,and gaps among different areas were still existed.From 2008 to 2012,Gini coefficients of three medical health resources including the doctors,nurses and health technicians were all under 0.3.And the fluctuant tendency of the Theli Indexes and Gini coefficients were accordant with no significant increase or decrease as a whole.The combination of differences within region and difference between regions leaded to the inequity of health human resource allocation in Zhao tong city,and within region in the contribution rate of the total Theil index was greater than the difference between regions.Conclusions The quantity of health human resource is not enough in Zhaotong.The equity fluctuation of three health resources has no significatnt change.The differences within region mainly cause the inequity of health resource allocation in public hospitals of Zhao tong city.
7.Investigation of the anxiety level and related factors in on-the-job nurses self-studying for master degree
Hong ZHU ; Li LIU ; Qiong-Zhen XIONG
Chinese Journal of Modern Nursing 2011;17(14):1636-1638
Objective To determine the level of anxiety in on-the-job nurses self-studying for master degree, and provide useful information to nursing managers for promoting the psychological health level of the nurses. Methods Nurses self-studying for master degree were investigated with self-Rated Anxiety Scale (SAS).Results The anxiety level in the nurses showed higher than that of the normal group in China (P<0.01), which was related to bed number in ward, years of night duty, and number of night duty per month. Moreover, nurses who engaged in clinical work, junior nurses and nurses working in surgery departments showed higher level of anxiety.Conclusions Anxiety was prevalent among nurses self-studying for master degree. The nursing managers should pay close attention to the mental health of nurses engaged in after graduate education and take effective measures to improve their coping abilities.
8.Sarcoidosis of kidney: report of a case.
Qiong-zhen LIN ; Li-hong ZHANG ; Hai-ying LIN ; Yan-qing CHI ; Bao-xing WANG ; Ying LI ; Wan-zhong ZOU
Chinese Journal of Pathology 2007;36(1):62-63
Adult
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Biopsy, Needle
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Diagnosis, Differential
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Humans
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Kidney
;
pathology
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Kidney Diseases
;
pathology
;
therapy
;
Male
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Nephritis, Interstitial
;
pathology
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Renal Dialysis
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Sarcoidosis
;
pathology
;
therapy
;
Tuberculosis, Renal
;
pathology
9.Effect of fluvastattn on extracelluar signal-regulated kinase activity in glomerular mesangial cells exposed to high glucose concentration
Ying LI ; Hui-Jun DUAN ; Tao ZHANG ; Li-Hong ZHANG ; Mao-Dong LIU ; Xiu-Fen WANG ; Qiong-Zhen LIN ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
When the glomerular mesangial cells of rats were cultured in vitro at high glucose concentration,the activity of extraeellular signal-regulated kinase(ERK),the expression of transforming growth factor-?_1(TGF-?_1)mRNA and the content of typeⅣcollagen in the supematant were higher than those at normal glucose concentration.These effects were inhibited by fluvastatin.The results showed that the activation of ERK signal transduction pathways appeared to play a role in the onset and progression of diabetic nephropathy. Furthermore,fluvastatin could protect the kidney by inhibiting ERK signal transduction pathway and TGF-?_1 expression.
10.The haematological phenotype and genotype analysis on 14 co-inheritance of hemoglobin Constant Spring and β-thalassemia.
You-qiong LI ; Ting YANG ; Xian-zhen LING ; Liang LIANG
Chinese Journal of Hematology 2013;34(12):1067-1069
Adolescent
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Adult
;
Child
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Child, Preschool
;
Female
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Genotype
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Hemoglobins, Abnormal
;
genetics
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Humans
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Infant
;
Male
;
Phenotype
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Young Adult
;
beta-Thalassemia
;
blood
;
genetics