1.Pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation on recurrent pterygium
Ting, LI ; Shu-Xian, CHEN ; Xu-Guang, XIA ; Zheng, YIN ; Mu-Zhen, HUANG ; Ping-Ying, GUO
International Eye Science 2014;(9):1715-1716
To discuss the effective method of decreasing the postoperative recurrence rate of recurrent pterygium.
●METHODS:Totally 126 cases (126 eyes) with recurrent pterygium were randomly divided into A group (56 cases) and B group ( 70 cases ). Group A was treated by pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation, group B was treated by amniotic membrane transplantation. The followed-up time after surgery was 6-24mo.
●RESULTS:ln group A, postoperative 5-7d (average 5. 62± 1. 38d), cornea epithelium was repaired. ln group B, postoperative 7- 10d ( average 7. 38 ± 1. 12d), the corneal wound was healed. There was statistical significant difference between two groups (t = 4. 307,P<0. 05). Three cases recurrence were noted in A therapeutic group (56 cases), the recurrent rate was 5. 4%; Twelve cases recurrence were noted in B compared group (70 cases), the recurrent rate was 17. 1%. There was statistical significant difference between two groups(P<0. 05).
●CONCLUSlON: lt is suggested that pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation is effective in the treatment of recurrent pterygium.
2.Primary mathematic analysis of SARS epidemic situation in a general hospital
Shixin WANG ; Shuhui YU ; Xizheng ZHANG ; Shaoxi CAI ; Yuming LI ; Zhen YANG ; Guo XIE ; Yongge MU
Chinese Medical Equipment Journal 2004;0(09):-
Based on the statistical materials of SARS epidemic process in a general hospital in 2003 and with least square method, the epidemic laws are fitted through MATLABL, and the infection characteristics and relative conclusions of SARS are analyzed.
4.Clinical features and imaging findings in pulmonary capillary hemangiomatosis: report of two cases and a pooled analysis.
Wan-Mu XIE ; Hua-Ping DAI ; Mu-Lan JIN ; Zhen WANG ; Yuan-Hua YANG ; Zhen-Guo ZHAI ; Chen WANG
Chinese Medical Journal 2012;125(17):3069-3073
BACKGROUNDPulmonary capillary hemangiomatosis (PCH) is a rare disease and no Chinese case has been reported yet. The disease is often misdiagnosed and its clinical characteristics are incompletely described. The aim of this study was to describe two Chinese cases and to clarify the clinical and radiographic parameters of patients with PCH.
METHODSTwo PCH cases were presented and other cases were searched from the English literature. All available clinical and radiographic data were collected from 62 literature reported PCH cases. A pooled analysis of total 64 cases was made.
RESULTSDyspnea and hemoptysis were the most common clinical symptoms of PCH. Pulmonary hypertension (PH) was found in 78% of the reported cases. PCH typically showed characteristic diffuse or patchy ground-glass opacities (GGOs) and/or multiple ill-defined centrilobular nodules in the computed tomography.
CONCLUSIONSThe diagnosis of PCH requires a high clinical suspicion. However, both clinical presentations and radiographic studies often provide clues to the diagnosis, which may prompt early lung biopsy for a definite diagnosis.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Hemangioma, Capillary ; complications ; diagnosis ; Humans ; Lung Neoplasms ; complications ; diagnosis ; Male ; Middle Aged ; Tomography, X-Ray Computed
5.Electron microscopic examination on 50 cases of prostatic needle biopsies.
Hui-zhen ZHANG ; Zhi-ming JIANG ; Mu-yi GUO ; Li ZHENG
Chinese Journal of Pathology 2010;39(9):587-590
OBJECTIVETo study the differences in ultrastructural findings between prostatic carcinoma and benign prostatic hypertrophy, and the various ultrastructural features seen in moderately to poorly differentiated prostatic carcinoma.
METHODSUtrasound-guided needle biopsies were carried out in 50 clinically suspicious cases of prostatic carcinoma. For each case, one additional core was sampled from the most suspicious area, fixed in glutaraldehyde and examined under electron microscopy.
RESULTSIn the 50 cases of prostatic needle biopsies studied, there were a total of 42 cases with histologic findings of prostatic carcinoma. Thirty-one cases showed features corresponding to Gleason's score 3 to 5. In contrast to that seen in benign prostatic hypertrophy, the ultrastructural findings of the tumor cells commonly seen in prostatic carcinoma included the centrally located giant nucleoli, a direct contact with stroma, and formation of cytoplasmic microcyst. Occasionaly, there were mitotic figures seen, accompanying with fibromyxoid change of the peritumoural stroma. Amongst the 31 cases of Gleason's score 3 to 5 prostatic carcinoma, 29 cases (93.5%) demonstrated cytoplasmic prostasomes and storage vesicles. Similar to their counterparts in benign prostatic cells, prostasomes and storage vesicles in prostatic carcinoma cells were formed in the Golgi apparatus and released into the lumen by apocrine excretion and exocytosis.
CONCLUSIONSElectron microscopy is helpful in distinguishing between benign and malignant prostatic lesions. Because of the high yield of prostasomes in moderately to poorly differentiated prostatic carcinoma, prostasomes may become a potential target for cancer immunotherapy and one of the useful diagnostic indices for delineating the prostatic origin of metastatic carcinoma.
Adenocarcinoma ; pathology ; ultrastructure ; Biopsy, Needle ; Carcinoma, Signet Ring Cell ; pathology ; ultrastructure ; Humans ; Male ; Microscopy, Electron, Transmission ; Prostate ; pathology ; ultrastructure ; Prostatic Hyperplasia ; pathology ; Prostatic Intraepithelial Neoplasia ; pathology ; ultrastructure ; Prostatic Neoplasms ; pathology ; ultrastructure
6.Study on the visible display of Meridian on the dummy human body.
Fang-fang MU ; Shui-jin SHAO ; Zhen-guo YAN ; Hong-ju LIU ; Jing ZHAO ; Tian-ge ZHUANG ; Yi-lin QIN
Chinese Acupuncture & Moxibustion 2006;26(8):575-577
OBJECTIVETo study on visible display of Meridian on the dummy human body.
METHODSTube model-building method and computer technique were used, and data came from Voxel-Man dummy human body development platform.
RESULTSThe visual effect of re-building Meridian is very good and it can display the different layers of anatomic structures on the Meridian lines.
CONCLUSIONThe visible display of Meridian on the dummy human body is preliminary realized, which provides data carriers for establishing the platform of Meridian study.
Human Body ; Humans ; Meridians
7.Biological effect of seed-coating in Carthamus tinctorins.
Jun CHEN ; Hui-zhen CHENG ; Wan-long DING ; Jing YU ; Xi-li LIU ; Li-dan MU ; Guo-zhen ZHANG
China Journal of Chinese Materia Medica 2003;28(8):714-718
OBJECTIVETo study the Biological effect of seed-coating in Carthamus tinctorins.
METHODTwo kinds of seedcoating chemicals SCF1 and SCF2 were used in this experiment, the seed YM-99 and 27981-99 were coated by three kinds of ratio of seedcoating chemicals to seed. It was investigated that the germination energy and germination percentage in the room and the emergence rate, seedling stage growing, pest in the field.
RESULTSeedoating can improve the emergence rate and seedling stage growing, it also can effectively control aphid, rust and virosis during the growing period in C. tinctorins.
CONCLUSIONSeedcoating has significant biological effect in C. tinctorins.
Carthamus ; growth & development ; Delayed-Action Preparations ; Germination ; drug effects ; Pesticides ; pharmacology ; Plant Diseases ; Plant Growth Regulators ; pharmacology ; Plants, Medicinal ; growth & development ; Seeds ; growth & development
9.The progress and challenges in immunotherapy for the difficulty- to- treat liver diseases
Jin FAN ; Xiuying MU ; Xiaoyan GUO ; Yuntian GUO ; Cheng ZHEN ; Yanning SONG ; Fusheng WANG
Chinese Journal of Hepatology 2021;29(7):609-614
As a digestive organ, the liver has the functions of metabolism, synthesis, and detoxification. It is also an immune organ and plays an important role in maintaining anti-infection, autoimmune stability, and anti-tumor. In particular, the liver has unique immunological advantages. Its immune cells can maintain the liver's immune homeostasis and participate in immunoregulation. A variety of immunotherapy is used in clinical trials for the treatment of difficult and critical liver diseases. This review mainly summarizes the recent clinical trials of immunotherapy in chronic hepatitis B, cirrhosis, hepatocellular carcinoma, and autoimmune liver disease.
10.Inhibition of proliferation in Jurkat cells transfected with exogenous HCAP1 gene.
Xiang-Hua WU ; Rong WANG ; Jun-Xiang DU ; Qi-Tian MU ; Lie-Ping GUO ; Pei-Er ZHEN ; Da-Fang WAN ; Jian-Ren GU
Journal of Experimental Hematology 2003;11(5):454-457
HCAP1 is a novel hepatic cancer related gene located on human chromosome 17p13.3. The loss of heterozygosity occurred at 17p13.3 in various human cancers. In order to investigate the effects of exogenous HCAP1 gene products on cell proliferation of T lymphoma Jurkat cell line, HCAP1 gene! was transfected into Jurkat cells mediated by liposome, and the cells stably expressing exogenous HCAP1 were screened with G418. The effects of HCAP1 products on cell proliferation were assessed by viable cell count, cell growth curve and colony formation assay in soft agar. The results showed that the HCAP1 transgenic Jurkat cells displayed slow growth rate, extended doubling time and reduced colony formation capability, as compared with the cells transfected with pBK/CMV empty vector (P < 0.01). It is concluded that exogenous HCAP1 gene products could inhibit the proliferation of Jurkat cells.
Carcinoma, Hepatocellular
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genetics
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Cell Division
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Humans
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Jurkat Cells
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Liver Neoplasms
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genetics
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Neoplasm Proteins
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genetics
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Peptides
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Transfection