3.Effects of Trillim tschonskii maxim on microvessels response and anti-oxidation enzyme in burned rats.
Chinese Journal of Applied Physiology 2011;27(4):483-494
Animals
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Burns
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drug therapy
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metabolism
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physiopathology
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Female
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Male
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Mesentery
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blood supply
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Microvessels
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drug effects
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physiopathology
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Phytotherapy
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Rats
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Rats, Sprague-Dawley
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Superoxide Dismutase
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metabolism
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Trillium
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chemistry
4.Current status of research on B cell lymphoma chemotherapy .
Zhong-zhen GUAN ; Shu-sen WANG
Chinese Journal of Oncology 2005;27(12):760-761
Antineoplastic Combined Chemotherapy Protocols
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administration & dosage
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therapeutic use
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Cyclophosphamide
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administration & dosage
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Doxorubicin
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administration & dosage
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Humans
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Lymphoma, B-Cell
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classification
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drug therapy
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therapy
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Prednisone
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administration & dosage
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Stem Cell Transplantation
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Vincristine
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administration & dosage
5.Transurethral enucleative resection of the prostate versus transurethral resection of the prostate for benign prostate hyperplasia.
Wei ZUO ; Zhen-Zhong WANG ; Jun XUE
National Journal of Andrology 2014;20(9):812-815
OBJECTIVETo compare the effectiveness and safety of transurethral resection of the prostate (TURP) and transurethral enucleative resection of the prostate (TUERP) in the treatment of benign prostate hyperplasia (BPH).
METHODSA total of 630 BPH patients with indication of surgery were randomly assigned to receive TURP (n = 305) and TUERP (n = 325), respectively. There were no significant differences preoperatively in age, prostate volume, International Prostate Symptom Score (IPSS), and Qmax between the two groups (P > 0.05). The prostate resection rate, operation time, postoperative complications, and quality of life (QOL) of the patients were recorded and statistically analyzed.
RESULTSCompared with TURP, TUERP showed a significantly higher rate of prostate resection ([47.0 +/- 13.3] vs [60.1 +/- 12.3]%, P < 0.05), shorter operation time ([57.9 +/- 15.9] vs [40.4 +/- 14.2] min, P < 0.05), and shorter bladder irrigation time ([2.7 +/- 0.6] vs [2.2 + 1.1] d, P < 0.05). Significant differences were found between the pre- and post-operative levels of serum sodium and hemoglobin in the TURP group ([141.2 +/- 3.5 ] vs [136.9 +/- 4.7] mmol/L, P < 0.01; [137.6 +/- 8.8] vs [124.8 +/- 9.6] g/L, P < 0.01), but not in the TUERP group. Three months after operation, IPSS, QOL, and Qmax were all markedly improved in both groups (P < 0.01), but with no significant differences between the two groups (P >0.05).
CONCLUSIONTUERP is better than TURP in the treatment of BPH for its advantages of higher resection rate of the prostate, shorter operation time and bladder irrigation time, less intraoperative blood loss, fewer postoperative complications, and faster recovery.
Aged ; Humans ; Male ; Prostatic Hyperplasia ; surgery ; Transurethral Resection of Prostate ; methods ; Treatment Outcome
6.Change of Urinary Leukotriene E_4 Level in Children with Respiratory Syncytial Virus Bronchiolitis and Its Clinical Significance
Ai-zhen, WANG ; Zhen-yu, ZHANG ; Luo-zhong, ZHAO
Journal of Applied Clinical Pediatrics 2006;0(16):-
Objective To explore the clinical significance of urinary leukotriene E4(LTE4) in children with respiratory syncytial virus(RSV) bronchiolitis.Methods Forty infants with bronchiolitis were enrolled for the identification of RSV-Ag from the nasopharyngeal secretions.Forty cases who were found to be positive of RSV were put into RSV bronchiolitis group.According to the severity of illness,the infants in RSV bronchiolitis group were separated into 2 subgroups:mild illness group (24 cases) and moderate illness group (16 cases).Thirty healthy children were chosen as healthy control group.Urine of the patients in RSV bronchiolitis group was collected in acute phase (on the 1st day) and recovery phase (on the 7th day after the admission).Urine of children in control group was collected .Enzyme-linked immunosorbent assay was used to assay the level of urinary LTE4.Results The levels of LTE4 in healthy control group (M,Q) were 1.28 pmol?mmol-1,1.72 pmol?mmol-1,while the levels of LTE4 in acute phase in RSV bronchiolitis group (M,Q were 30.52 pmol?mmol-1,23.56 pmol?mmol-1,and the levels of LTE4 in recovery phase in RSV bronchiolitis group (M,Q) were 3.98 pmol?mmol-1,3.43 pmol?mmol-1.Urinary LTE4 levels in acute phase in RSV bronchiolitis group were significantly higher than those in healthy control group (P
7.Protective effects of bone marrow stromal cells on ischemia/reperfusion hippocampal slices
Chi ZHONG ; Zhen QIN ; Chunjiu ZHONG ; Yang WANG ; Xiny SHEN
Chinese Journal of Pathophysiology 1989;0(06):-
AIM: To study the protective effect of bone marrow stromal cells (MSCs) on ischemia /reperfusion hippocampal slices. METHODS: Ischemia/reperfusion models of hippocampal slices from newborn rats were established. MSCs obtained from adult bone marrow were cultured, isolated and purified. Cell death was assessed using propidium iodide fluorescence. And brain-derived neurotrophic factor (BDNF) expression in MSCs was determined by immunocytochemistry and Western blot. RESULTS: Maximal dead cells appeared in hippocampal slices 3 to 7 days after reperfusion. When the slices were co-cultured with MSCs, only a few cells were dead. The protective effect of MSCs on the slices was diminished significantly when anti-BDNF antibody was added to the medium. The protein of BDNF was faintly expressed in MSCs under normal conditions. When MSCs were co-cultured with ischemia /reperfusion hippocampal slices, the expression of BDNF in MSCs was increased gradually especially when co-cultured for 3 to 7 days. However, MSCs co-cultured with normal hippocampal slices expressed BDNF at a lower level at any times of co-culture. CONCLUSIONS: In an in vitro model of simulated ischemia, MSCs reduce cell death. Ischemia/reperfusion hippocampal slices co-cultured with MSCs promote the expression of BDNF in MSCs, which in turn protect the ischemic neurons.
8.Coblation inferior turbinate reduction versus inferior turbinectomy with debrider
Zhen ZHONG ; Shuifang XIAO ; Huili WANG ; Guixiang WANG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(05):-
OBJECTIVE To compare coblation inferior turbinate reduction with inferior turbinectomy by evaluating the differences in the degree ofintraoperative bleeding,degree of post-operative pain,and short-term efficacy in treating inferior turbinate hypertrophy. METHODS Thirty-nine patients were involved in this study. Twenty-five underwent coblation inferior turbinate reduction,and fourteen were treated with inferior turbinectomy with debrider. Subjective symptoms and the inferior turbinate scores were assessed prior to and at 1,3 and 6 months after treatment. In the coblation group,4-6 tunnels were made in each inferior turbinate with Reflex 45 wand under local anesthesia with endoscope. In the control group,debrider was used to remove the hypertropic mucosa of inferior turbinates under endoscope, after which nasal package were used for 2 days to stop the bleeding. RESULTS Coblation inferior turbinate reduction resulted in little intraoperative bleeding and a significant reduction in post-operative pain. At the month 1 follow-up,the severity and the frequency of nasal obstruction were significantly improved in both the coblation and control group. The inferior turbinates were found to have significantly decreased in size in both groups. There was no significant difference between the two groups. At the month 3 follow-up,these improvements were also significant,and the frequency of nasal obstruction was significantly more reduced in the coblation group. The results from the month 6 follow-up conformed to those from the month 3 follow-up. CONCLUSION Coblation inferior turbinectomy is a safe procedure that is easily performed under local anesthsia and results in a significant improvement of nasal obstruction in patients with turbinate hypertrophy. The volumes of the inferior turbinates were alsosignificantly reduced. This procedure is as effective as inferior turbinectomy with debrider. The clinical benefitpersists at 6 months after the procedure.
10.Experimental research on the anti-aging effects of astragalus polysaccharides.
Ling ZHONG ; Zhen-Fui WANG ; De-Jian WEN
Chinese Journal of Applied Physiology 2013;29(4):350-352
Aging
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drug effects
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Animals
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Astragalus Plant
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Blood
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metabolism
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Brain
;
metabolism
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Female
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Glutathione Peroxidase
;
metabolism
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Liver
;
metabolism
;
Male
;
Malondialdehyde
;
metabolism
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Mice
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Mice, Inbred Strains
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Polysaccharides
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pharmacology
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Superoxide Dismutase
;
metabolism