1.Changes of calpain in renal tubular epithelial cells during kidney ischemia/reperfusion injury of neonatal rats.
Bo YU ; Yu-jia YAO ; Zhen-lang LIN
Chinese Journal of Pediatrics 2005;43(10):789-791
Animals
;
Calpain
;
metabolism
;
Epithelial Cells
;
metabolism
;
Kidney
;
cytology
;
Kidney Tubules
;
cytology
;
metabolism
;
Rats
;
Reperfusion Injury
;
metabolism
2.Observation on therapeutic effect of double unrelated umbilical cord blood transplantation for treatment of leukemia due to chronic benzene poisoning in adults.
Ling-zhen CHEN ; Jia-yu CHEN ; Jin-ming WU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(5):361-362
Adult
;
Benzene
;
poisoning
;
Cord Blood Stem Cell Transplantation
;
Female
;
Humans
;
Infant, Newborn
;
Leukemia
;
etiology
;
surgery
;
Male
;
Treatment Outcome
;
Young Adult
4.Chemical constituents from roots of Euphorbia songarica
Jia LIN ; Ning AN ; Chun-Yu LIU ; Li-Zhen XU ;
Chinese Traditional and Herbal Drugs 1994;0(04):-
Objective To study the chemical constituents from the roots of Euphorbia sonngarica. Methods Compounds were isolated by Sephadex LH-20,MPLC,and silica gel column chromatographies. Their structures were identified by spectral methods together with physicochemical analysis.Results Eleven compounds were isolated from the roots of E.sonngarica.They were identified as cryptomeridiol (Ⅰ),betulin(Ⅱ),betulinic acid(Ⅲ),3?-hydroxy-olean-12-en-28-oic acid(Ⅳ),7-oxo-?sitosterol (Ⅴ),erythrinasinate(Ⅵ),octaeosanoie acid(Ⅶ),1-octacosene(Ⅷ),24-methene-cycloartenol(Ⅸ),eu- phol(Ⅹ),?-sitosterol(Ⅺ).Conclusion CompoundsⅠ-Ⅷare isolated from this plant for the first time.
6.Advancements in stabilization technologies for membrane protein and its application in drug screening
Jia-hao FANG ; Yu-hong CAO ; Yu-zhen HE ; Zhan-ying HONG ; Yi-feng CHAI
Acta Pharmaceutica Sinica 2021;56(9):2325-2334
Membrane proteins are the main undertakers of biofilm function, and also the most important target group for innovative drug discovery and research. About 60% of drugs targets are membrane proteins. Due to the obvious aggregation and denaturation tendency of membrane proteins in aqueous solution, it is difficult to simulate the membrane like environment to maintain the correct conformation of membrane proteins
7.Application of the second metatarpophalangeal joint by traction prolong transplant repair the defects in the metacarpophalangeal joint
Jian-Wen LIAO ; Ze-Hua CHEN ; Jia-Chuan ZHUANG ; Jia-Jun ZHANG ; Zheng LI ; Shao-Xiao YU ; Zhen-Wei ZHANG ;
Chinese Journal of Microsurgery 2006;0(05):-
Objective Application of the second metatarpophalangeal joint by traction prolong trans- plant repair the defects in the metacarpophalangeal joint,reconstruct the function of it.Methods By means of the apparatus to prolong finger in advance,then transplant the second metatarpophalangeal joint to recon- struct metacarpophalangeal joint for seven cases of obsolete defects in the metacarpophalangeal joint.Results The average of finger prolong was 2.6 cm,consultation from 1 to 4 years.average 2.5 years,thai the trans- plant joints have all survived and osteal concrescence.Through the criterion Chinese Medical Association,good rate was 85.7%. Conclusion It' s a good method to repair obsolete defects in the metacarpophalangeal joint by transplant traction prolong of the second metatarpophalangeal joint.
8.Angiomyolipoma of the kidney with lymph node involvement.
Chuan-Zhen WU ; Feng-Hua WANG ; Cheng-Mei LI ; Wen-Chang FANG ; Jia-Ni YU
Chinese Journal of Pathology 2005;34(11):715-715
Adrenalectomy
;
Adult
;
Angiomyolipoma
;
pathology
;
surgery
;
Follow-Up Studies
;
Humans
;
Kidney
;
pathology
;
Kidney Neoplasms
;
pathology
;
surgery
;
Lymph Node Excision
;
Lymph Nodes
;
pathology
;
Lymphatic Metastasis
;
Male
;
Nephrectomy
;
Ureter
;
surgery
9.Study on mental stress life events in patients with cyclomastopathy of liver stagnation syndrome type.
Qiong ZHANG ; Jia-Xu CHEN ; Zhen YU
Chinese Journal of Integrated Traditional and Western Medicine 2007;27(6):509-512
OBJECTIVETo observe the changes of mental stress life events (MSLE) in patients with cyclomastopathy of liver stagnation syndrome type (LSS).
METHODSClinical epidemiological research method was adopted, the changes of MSLE were observed in cyclomastopathy patients of LSS or non-LSS, classified by syndrome differentiation of TCM.
RESULTSNot only the mean age (33.38 +/- 6.76 years) of patients with LSS was obviously lower than that of patients with non-LSS (38.36 +/- 9.89 years, P < 0.01), but also the mean age of patients with moderate and serious symptoms of LSS (33.96 +/- 7.31 and 37.43 +/- 7.38 years) were higher than that of patients with mild symptoms of LSS (31.67 +/- 5.39 years, P < 0.05 and P < 0.01). MSLE score of patients with LSS (32 scores) was significantly higher than that of patients with non-LSS (22 scores, P < 0.01). MSLE score of patients with moderate and serious LSS was 34.69 +/- 17.78 scores and 51.65 +/- 20.75 scores respectively, both were significantly higher than that of patients with mild LSS (26.57 +/- 15.85 scores, P < 0.05 and P < 0.01).
CONCLUSIONThe high incidence age of cyclomastopathy is under 40 years, and most of cyclomastopathy patients are classsified to LSS by TCM syndrome differentiation. So age and life event scores may be the objective bases for syndrome typing and liver stagnation syndrome grading in patients with cyclomastopathy.
Adult ; Age Factors ; Analysis of Variance ; China ; epidemiology ; Diagnosis, Differential ; Female ; Fibrocystic Breast Disease ; diagnosis ; epidemiology ; etiology ; Humans ; Medicine, Chinese Traditional ; Middle Aged ; Stress, Psychological ; complications ; Syndrome ; Young Adult
10.Study on preparation and in vitro characteristics of ginsenoside Rg3 binary solid dispersion.
Qi-Yuan LIU ; Zhen-Hai ZHANG ; Xin JIN ; Zhao-Hui YU ; Xiao-Bin JIA
China Journal of Chinese Materia Medica 2013;38(24):4298-4302
With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction (X-RD) were adopted for a phase analysis. The results showed that the 60 min in vitro cumulative dissolution rate of ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 at the ratio of 2:1 exceeded 90%, and the drug was dispersed in carriers in an amorphous state. Therefore, ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 could help significantly improve the drug dissolution, with a practical application value.
Chitosan
;
chemistry
;
Drug Compounding
;
methods
;
Ginsenosides
;
chemistry
;
Molecular Weight
;
Poloxamer
;
chemistry
;
Solvents
;
chemistry