Objective To describe the academic impact of publications from National Institute of Parasitic Diseases （NIPD），Chinese Center for Disease Control and Prevention，so as to give the quantity evidence for scientific research decision making. Methods The SCIE papers of NIPD published from 2011-2015 were searched and statistically analyzed. The number of published papers，citation frequencies，h⁃index，and funding resources were analyzed. The academic impact of the institute was assessed according to these data. Result A total of 361 papers were published by NIPD，and the quantity increased year by year. The majority type is original articles. The total citations were 1 641 times，the average citation per paper was 5.19 and h⁃index was 17. The majority of these papers were published in foreign professional periodicals，whose impact factors were between 1.194 and 6.751. The major resources of NIPD were from China，and NIPD also had good collaborations with institutions in US and Switzerland. In China and Asia，NIPD led the research in the field of parasitology and tropical medicine. Conclusion The quantity and quality of annual published papers of NIPD are on the rise. However，NIPD lagged behind the leading institutions in the world.

Objective:For improving the imperfection of the Active contour model.Methods:This paper puts forward a new active contour model based on the greedy algorithm.The average contour length term is added into the internal energy of the model.The gradient directional energy is introduced to the external energy of the model.A fast algorithm is introduced to solve the minimum of region energy.The algorithm of add or delete snaxel also adopted in this paper.Segmentation of the MRI brain tumor are studied in the experiments.Results:Comparing to the manual segmentation and the GVF segmentation,the method is better.Conclusion:The results of experiments indicate that the model is none sensitive to initial contour.So this algorithm is practical.

The paper briefly introduces the definition, characteristics of MOOC and its development both in China and abroad, ana-lyzes the relation between medical college and university library and MOOC.It points out that libraries should provide embedded course services based on MOOC, establish MOOC Information Commons ( IC) , develop MOOC specialized database and enhance capability of the librarians in order to develop MOOC from various aspects and continuously promote information service innovation.

OBJECTIVE To know the incidence, etiology, risk factors of hospital-acquired pneumonia(HAP). METHODS From Jan 2003 to Dec 2004, 129 cases of HAP were retrospectively studied. Epidemiologic data, etiology , and evolution of pneumonia were recorded. RESULTS The 115 patients with HAP had one or more intrinsic risk factors, mainly malnutrition (albumin values

Hypoglycemia is a common and early metabolic disease of neonate.Serious and persistent hypoglycemia could result in brain damage.So far the pathogenesis of the disease is on research,but the definition of hypoglycemia,the glucose threshold of intervention,and diagnostic criteria of brain damage are still unclear.The pathogenesis of hypoglycemia is complicated.Brain damage may be related to the specific excitory amino acids receptors,reduced blood flow in occipital lobe,and cerebral hypoxia and ischemia.Diffusion weighted imaging of brain MRI and magnetic resonance spectroscopy are strongly recommended for the diagnosis of brain damage.Besides,clinical manifestation and cerebral function monitor are also included in the diagnosis.The threshold of intervention is suggested as serum glucose concentration with 2.2 ～ 2.6 mmol/L.

Pancreatic cystic lesions are being recognized increasingly due to the development of computed tomography and magnetic resonance imaging.Differential diagnosis between pseudocysts and cystic tumors is the key point for pancreatic cystic lesions.Patients with pancreatic pseudocysts generally have a history of acute or chronic pancreatitis,whereas patients with cystic tumors did not have such a history.Some pancreatic cystic lesions did not have typical imaging presentations,and they were difficult to be diagnosed.Pancreatic cystic lesions could be divided into unilocular cysts,microcystic lesions,macrocystic lesions and cysts with a solid component according to the presentations under computed tomography and magnetic resonance imaging.This typing system is helpful for the diagnosis and differential diagnosis of pancreatic cystic tumors,as well as for the guidance of therapy.

AIM: To observe the effect of nonpenetrating trabeculectomy with implantation of amniotic membrane on the treatment of open-angle glaucoma.METHODS: Sixty-six cases (87 eyes) were randomly paired into 3 groups, treated with nonpenetrating trabeculectomy with implantation of amniotic membrane (22 cases, 29 eyes),compound trabeculectomy (22 cases, 29 eyes) and nonpenetrating trabeculectomy with implantation of SKGel (22 cases, 29 eyes), respectively.RESULTS: Compared with the other 2 groups, the group of nonpenetrating trabeculectomy with implantation of amniotic membrane got a better postoperative visual acuity (P＜0.01),satisfactively-controlled intraocular pressure (IOP) (P＜0.01)and fewer complications (P＜0.01).CONCLUSION: Nonpenetrating trabeculectomy with implantation of amniotic membrane is an effective method for the treatment of open-angle glaucoma.

Background Multifocal intraocular lens (IOL) can produce two focus distance based on the principle of diffraction-refraction,and the full range of vision is better than monofocal IOL.So multifocal IOL can provide cataract patients better far,middle and near distant vision.Objective This study was to investigate and compare the clinical efficacy between multifocal IOL and monofocal IOL implantation in the patients after cataract surgery.Methods One hundred eyes of 100 patients with cataract enrolled in Gaomi People's Hospital from June 2010 to September 2012 and were divided into the monofocal IOL group and multifocal IOL group,with the matched demographic and medical baseline characteristics between the two groups.All the patients were aware of the trial and a written informed consent was obtained from each patient prior to the surgery.Multifocal IOL (Acrysof ReSTOR SA60D3) was implanted in the multifocal IOL group,and monofocal IOL was implanted in the monofocal IOL group after phacoemulsification.Uncorrected distant visual acuity (UCDVA),best corrected distant visual acuity (BCDVA),uncorrected near visual acuity (UCNVA),best corrected near visual acuity (BCNVA),uncorrected middle distance visual acuity (UCMVA) and distant-corrected near visual acuity (DCNVA) between the two groups were observed and compared,and near stereo acuity,IOL higher-order aberrations under the pupillary diameters of 3 mm and 5 mm,optimum reading distance and reading speed were compared 3 months after surgery.The satisfaction rates of patients for each visual function district were analyzed by a questionnaire survey.Results UCNVA and DCNVA in the multifocal IOL group were significantly better than those of the monofocal IOL group 3 months after surgery,and the differences were statistically significant (t=15.48,22.44,both at P＜0.05).UCMVA at the distance of 25,30,40,50,60 cm in the multifocal IOL group were better than ones of the single IOL group (t=12.60,16.75,23.18,14.04,7.60,all at P＜0.05).Uncorrected near stereo acuity in the multifocal IOL group was (49.1 ±15.2),showing a significant reduction in comparison with (85.3 ± 18.6) of the multifocal IOL group (t=10.66,P＜0.05).The total higher-order aberrations,spherical aberration and coma under the pupil diameter of 3 mm and 5 mm were not significantly different between the two groups (all at P＞0.05).The optimal reading distance in the multifocal IOL group was (33.5 ± 4.1) cm,and was significantly shorter than (46.3 ± 5.2) cm of the monofocal IOL (t=13.67,P＜0.05).The reading speed in the multifocal IOL group was (172.5 ± 52.3) words/minute,and that in the monofocal IOL group was (108.3 ± 31.4) words/minute,with the significant difference between them (t =7.44,P＜0.05).The patients who were satisfied with the functional areas of near vision and middle-distance vision were more in the multifocal IOL group than those of the monofocal IOL group (x2=56.59,40.85,both at P＜0.05),but those in the distance vision zone between the two groups was no significant different (x2=3.09,P＞0.05).Conclusions Comparison with the monofocal IOL,multifocal IOL implantation for the treatment of cataract can obtain clear imaging both at the far-distance and middle-and near-distance.Multifocal IOL implantation can improve the life quality of cataract patients after operation.

Objective To explore the evaluation for apraxia of speech (AOS) with Chinese. Methods 20 Chinese cases with AOS were assessed with Chinese material referred from Motor Speech Evaluation (MSE) using. Results The subtest of multiple repetitions of multisyllabic words was the most difficult and single repetitions of monosyllabic words was the easiest for AOS patients (P<0.05). The score of the short sentences negatively correlated with both the scores of repetition ability (r=-0.865) and the fluency of speech (r=-0.614) (P<0.001).Conclusion Chinese material referred from MSE can be used for evaluation of AOS with Chinese.

Objective:To seek better treatments for abnormal pelvic floor muscle tension and pelvic floor dysfunction after spinal cord injury.Methods:The morphology of pelvic floor muscle fibers of rats with spinal cord injury at different levels was observed under the electron microscope. Thirty female adult Sprague-Dawley rats were randomly divided into a suprasacral (SS) cord injury group, a group with spinal cord injury at or below the sacral level (SC) and a normal group (NG), each of 10. The relevant spinal cord injury models were established in the SS and SC groups through spinal cord disconnection. Four weeks later, the pixel area of ATPase-positive fibers was used to quantify the content of type I fibers in the pubococcygeus muscle of each rat through observation under the electron microscope after hematoxylin and eosin staining.Results:The average content of type I muscle fibers in both the SS and SC group was significantly lower than in the normal group. The SC group′s average level was significantly lower than that of the SS group. Under the microscope the stained myofibers were tortuous, deformed in appearance and with proliferated nuclei. Capillary dilation could be seen locally in the SS group 4 weeks after the injury. In the SC group at 4 weeks after the injury the pubococcal fibers were seriously "dissolved" , or disordered, with spherical nuclei and mild hyperplasia. Under the electron microscope, the sarcomeres of the SC group were obviously dissolved, atrophied and broken, though the basic structure persisted, with mild mitochondrial proliferation. The sarcomeres of the SC group were extremely dissolved and broken, completely losing basic structure, with abundant connective tissue proliferation but without obvious mitochondrial proliferation.Conclusions:After suprasacral cord injury, the content of type I muscle fibers in the pubococcygeus muscle of the pelvic floor decreases somewhat, with the basic structure of the muscle fibers remaining intact. However, after spinal cord injury at or below the sacral level, type I muscle fibers decrease significantly in the pubococcygeus muscle of the pelvic floor, and the basic structure is seriously damaged.