Objective To stndy the clinical efficacy of bicyclol treatment for chronic hepatitis B.Methods 70 cases of chronic hepatitis B patients were randomly divided into 2 groups;35 cases in test group,with bicyclol 75mg daily,and 35 cases control group,in with SNMC 150mg daily patients in the 2 groups got continuous medication for 12 weeks.levels of serum aminotransferase changes before and after treatment were observed.Results Serum aminotransferase decreased more significantly in test group(P

Colorectal cancer is one of the most common malignant tumors. Though the development of multidisciplinary therapy has largely improved the therapy effects, many patients still died of local recurrence and metastases after surgery. Circulating tumor cell (CTC) originates from primary tumor tissues and has a close relationship with cancer metastases and prognosis. This review summarizes the CTC detection methods and relevant clinical research on CTC in recent years.

Caveolin-1 is an important surface structural marker of Caveolae. It is closely involved in the proliferation, apoptosis, invasion, metastasis, angiogenesis, signal transduction and multi-drug resistance of various tumor cells. Recent studies have found that altered Caveolin-1 expression has dual roles, as a tumor suppressor and promoter, in different stages of gastrointestinal cancer development and progression. The exact mechanisms of Caveolin-1s' involvement in the development of gastrointestinal cancer remain to be clarified and have attracted the attention of a lot of researchers.

Child ; Female ; Hemoptysis ; etiology ; Humans ; Lupus Erythematosus, Systemic ; complications ; diagnosis

Carcinosarcoma ; Female ; Humans ; Maxillary Sinus Neoplasms ; Middle Aged

Objective To investigate the accuracy of end-tidal carbon dioxide (PETCO2) in reflecting arterial carbon dioxide (PaCO2) during mechanical ventilation via laryngeal mask airway (LMA) in children. Methods Fifty-two ASA Ⅰ patients, aged 2-9 yr, weighing 10-30 kg, undergoing orthopaedic surgery under general anesthesia, were randomized into 2 groups (n = 26 each) : LMA group and endotracheal tube (ETT) group. After anesthesia was induced with fentanyl, propofol and succinycholine, LMA or ETT was inserted and the children were mechanically ventilated. After the hemodynamics was stable, arterial blood samples were obtained to detect PaCO2, and PETCO2 was recorded simultaneously. Results There was no significant difference in PaCO2 and PCT CO, between groups LMA and ETT ( P ＞ 0.05) . There was no significant difference between PaCO2 and PETCO2 in LMA group (P ＞ 0.05). Conclusion When mechanical ventilation is performed via LMA in children, PETCO2 can reliably reflect PaCO2 and guide the regulation of ventilatory parameters.

BACKGROUND: Cardiac function of patients with hypertension is impaired to various extents. How does the impairment level of cardiac function of patients with hypertension differ at various stages?OBJECTIVE: To observe cardiac function of patients with hypertension at various stages and compare the indexes with those of healthy people.DESIGN: Case-control and comparative observation.SETTING: Department of Special Treatment, General Hospital of Shenyang Military Area Command of the Chinese PLA.PARTICIPANTS: Totally 100 patients with hypertension were selected from the Internal Medicine Department of General Hospital of Shenyang Military Area Command of the Chinese PLA between October 2002 and May 2003. Among them, 30 cases of hypertension were at stage Ⅰ , 40 at stage Ⅱ and 30 at stage Ⅲ. At the same time period another 30 healthy people were selected as the control group. All the subjects signed the informed consent.METHODS: Cardiac function of the included subjects were detected with XJS-Ⅰ cardiac function testing equipment. Patients were tested at supine position and electrode was put on the basis of four-probe method.Breath was held at the end of expiration; meanwhile, lead electrocardiograph Ⅰ, cardiophonogram, cardiac admittance differential coefficient method and beating of carotid artery were recorded. Various indexes were processed with the computer. Detected indexes were heart rate, ejection prophase, ejection time of left ventricle, ejection prophase/ejection time of left ventricle, delay time of electro-machine, isovolumetric contraction time, isovolumetric contraction time/ejection time of left ventricle, time of pulse wave transmission, stroke volume, cardiac output, cardiac index,stress index of myocardial contraction, total peripheral resistance, and vascular compliance.MAIN OUTCOME MEASURES: Comparison of cardiac function between hypertensive patients at various stages and healthy people.RESULTS: All the 100 patients with primary hypertension and 30healthy people entered the final analysis. [1] Ejection prophase, isovolumetric contraction time, peripheral resistance, ejection prophase/ejection time of left ventricle and isovolumetric contraction time/ejection time of left ventricle: Those of hypertensive patients were obviously longer or stronger than those of the healthy subjects (P ＜ 0.01); those of patients with hypertension at stages Ⅱ and Ⅲ were obviously longer or stronger than those of patients with hypertension at stage Ⅰ (P ＜ 0.01). [2] Stroke volume, cardiac output, stress index of myocardial contraction, vascular compliance, time of pulse wave transmission and cardiac index: Those of hypertensive patients were obviously shorter or weaker than those of the healthy subjects (P ＜ 0.01); those of patients with hypertension at stages Ⅱ and Ⅲ were obviously shorter or weaker than those of patients with hypertension at stage Ⅰ (P ＜ 0.01). Among the indexes mentioned above, vascular total peripheral resistance of hypertensive patients at stage Ⅲ was obviously stronger than that of hypertensive patients at stage Ⅱ (P ＜ 0.05),but vascular compliance of the latter ones was obviously than that of the former ones (P ＜ 0.05).CONCLUSION: Cardiac function of patients with hypertension is decreased as compared with that of healthy people, and tends to further decrease with the development of hypertensive condition.

Background and purpose:Resistance to antitumor agents is a major cause of treatment failure in patients with breast cancer. Research has shown that, tumor stem cell marker aldehyde dehydrogenase 1 (ALDH1) is related with some anticancer drugs (such as cyclophosphamide, cisplatin) resistance, and the content of ALDH1 in tumor cells after treatment is higher than that before treatment. Breast cancer resistance protein (BCRP) is not expressed in normal tissues, but high expressed in breast cancer of after treatment, it may be associated with the mechanism of tumor drug resistance. This study was to investigate the correlation between expression and the relationship between these two kinds of protein ALDH1, BCRP and clinical pathological characteristics. Methods:Immunohistochemistry was performed to detect the expression of ALDH1 and BCRP in breast inifltrating ductal carcinoma tissues, and whether there is a correlation between and explore their relationship with clinical pathological features and their expression. Results:The expression of ALDH1 protein and BCRP protein in breast cancer and paracarcinoma breast tissues has signiifcant difference(χ2=14.685, P=0.000;χ2=12.243, P=0.000).The expression of ALDH1 with patients age, pathologic stage, axillary lymph node metastasis, histological grading, ER, PR, and HER-2 state were not relevant(P>0.05). HER-2, BCRP protein, expression was higher in cancer tissue (χ2=5.289, P=0.021). There were no relevant with the expression of BCRP with patients age, pathologic stage, axillary lymph node metastasis and histological grading, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER-2) (P>0.05). Conclusion:ALDH1 proteins may be an independent factor compared with occur drug resistant protein, and participate breast cancer drug resistance in the chemotherapy and tumor invasion and metastasis of malignant biological behavior.

Objective To investigate the relationship between heart failure with normal ejection fraction and cardiac remodeling.Methods One hundred and eighty-eight cases with chronic heart failure were collected from January 2009 to March 2012 from Department of Cardiology of Longkou People's Hospital.In strictly accordance with the diagnostic criteria,participants were divided into HFNEF(n =109) and HFREF groups (n =79).According to the NYHA classification,HFNEF and HFREF patients were further divided into three subgroups respectively (HFNEF patients:52 cardiac function Ⅱ,36 cardiac function Ⅲ,21 cardiac function Ⅳ ;HFREF patients:13 cardiac function Ⅱ,27 cardiac functionⅢ,39 cardiac functionⅣ).The measurements of the left ventricular ejection fraction (LVEF),left atrial diameter (LAD),interventricular septal thickness (IVST),left ventricular posterior wall thickness (LVPWT),right ventricular diameter (RVD) were conducted in all objects and their clinical data were statistically analyzed.Results Compared with HFREF patients,HFNEF group had older mean age ((64.59 ± 5.34) yrs vs.(58.89 ± 4.23) yrs,t =3.345,P =0.001),more female patients (58.7％ (64/109) vs.41.8％ (33/79),x2 =5.265,P =0.022),higher incidence of hypertension (81.65％ (89/109) vs.63.29％ (50/79),x2 =8.012,P =0.005).LVPWT,IVST,LAD,RVD gradually increased in HFNEF patients with the severity of cardiac function,with significant differences in LVPWT ((9.05 ± 1.89) mm vs.(11.30 ± 2.67) mm vs.(13.90 ± 2.77) mm,F =3.578,P =0.028),IVST ((9.35 ±1.75)mm vs.(11.51 ±2.48)mm vs.(12.98 ±3.01)mm,F =3.081,P =0.048),LAD ((31.23 ±5.98)mm vs.(35.55 ±7.31)mm vs.(44.81 ± 10.72)mm,F =6.711,P ＜0.001),but no difference in RVD ((18.95 ±1.02) mm vs.(19.21 ± 1.11) mm vs.(19.99 ± 0.98) mm,F =2.751,P ＞ 0.05).There was significant difference in LVPWT ((13.90 ±2.77)mm vs.(7.45 ±2.01)mm,t =11.439,P ＜0.001),IVST ((12.98 ±3.01)mm vs.(7.23 ± 1.94)mm,t =10.318,P ＜0.001),RVD ((19.99 ±0.98)mm vs.(23.51 ± 1.10)mm,t =2.838,P ＜ 0.001) between HFNEF and HFREF patients with Ⅳ level of cardiac function,while there was no statistical difference ((44.81 ± 10.72) nn vs.(46.30 ± 11.76) mm),t =1.451,P =0.151) on LAD.Conclusion Senior age,high proportions of women and essential hypertension are found in HFNEF patients.Impaired cardiac function has increasing impact on cardiac remodeling with the increase of severity but it almost has no effect on the right ventricle.Ventricular structural changes exist significantly different from HFNEF to HFREF.Therefore clinicians should have in-depth understanding of the characteristics of the HFNEF and its epidemiology,pathophysiology,diagnostic criteria and treatment principles in order to improve diagnosis and treatment of this class of patients.

Objective:To evaluate the preoperative and postoperative management in lung volume reduction surgery for patients with chronic obstructive pulmonary disease.Methods:All 7 patients were male.Age ranged from 65～76 years.Preoperative dyspnea index was grade 4 in 4 and grade 3 in 3.FEV1 were all less than 50%.We performed unilateral Lung volume reduction surgery on the lung that was estimated to have poorer lung function.The resected lung volume was 20%～30% of the operated.Results:2 tracheotomy were performed.Postoperative oxygen supply lasted 6～8d.The symptoms such as palpitaion,dyspnea were improved significantly.FEV1 and dyspnea index were respectively increased by 30%～45% and 1～2 grade.All patients recovered.Conclusions:Preoperative adjustment of the balance of water and electrolyte,proper respiratory exercises,resasonable postoperative oxygn supply and maintenance of unobstructed respiratory tract,all these are important.Moreover,tracheotomy shoulde be perfored promptly in acute cases.