Biomedical Research ; methods ; Drug Therapy, Combination ; Humans ; Medicine, Chinese Traditional ; methods ; trends ; Research Design

Objective To explore the effect on the neural endocrine and gastro intestinal functions when using Chinese traditional medicine in the treatment after the gyno-pathy operation of the wond's complete cutting off. Methods To compare 86 postoperative cases of gyno-pathy (womb's complete cutting off) being treated partly with Chinese medicine wiht the same 75 cases treated during the same period without Chinese medicine in order to investigate the different effect on the recovery of their neural endocrine and gastric intestinal functions. HZ Results The result shows that the patients in the tested group can recouer quickly while the neural endocrine and the gastro intestinal functions of the opposite group cannot recouer or recover very slowly in a long time. Conclusion Traditional Chinese medicine is rather helpul for the recovery of thd postoperative gyno-pathy patients if it is correctly used .

Nowadays, it is necessary to emphasize the three basic inseparable elements in the treatment of severe burn infection, which are systemic care, burn wound care, and rational use of antimicrobials topically or systematically. Systemic care has been shifted from simple nutritional support to maintaining the systemic homeostasis, including balancing immune-inflammatory response, and protecting organs from dysfunction. Some work focused on regulating systemic immune response in the initial phase and the balance of inflammatory response after occurrence of severe burn infection have been reported. These results at least broaden our thinking to recognize that treatment should not only destroy microbes, but also balance the response of the body. Escharectomy in earlier phase has been a consensus. Currently, we turn our vision into how to use "damage control surgery (DCS)" concept in management of severe burn. DCS in burn care includes the evaluation of perioperative situation more accurate to make a more appropriate surgical decision. Meanwhile, an overall strategy should be established to confront the rapidly increasing drug resistance of the pathogens. The release of endotoxin after use of antimicrobials, which has been studied widely, should be explored further.
Anti-Infective Agents ; therapeutic use ; Burns ; complications ; therapy ; Humans ; Infection Control ; Systemic Inflammatory Response Syndrome ; therapy

Objective To set up a neural network model and system to be applied in color selection of anterior porcelain prosthesis, and to improve its cosmetic effect. Methods The image was automatically captured by digtal camera, and pre processed. The values based on the three stimulation value were adopted for the colour selection and tooth colour matches from nine zone colors with 21 point smoothly transitional calculation. The three dimension view of the teeth was recovered. Tooth colors storage was set up and the characteristics for sample teeth and lost teeth were selected and retrieved to match the colour through artificial neural network automatically for personalized design of teeth colour. Results The method of anterior prosthesis for computerized color selection based on artificial neural network had a higher accuracy. By comparision, the satisfaction of patients, dentists and viewers was much higher than that without computer aided design, and patients' eveluation for the prosthesis was higher than that of dentists. Conclusion The design system for colour selection of the front tooth prosthesis has a great value in clinical application, and it has developed the theory of artificial neural network used in the field of stomatology.

Purpose:To analyze the dependence of a cu te esophagitis (AE) on the dose and volume of irradiated esophagus during concur rent chemoradiation therapy of NSCLC.Methods:39 NSCLC patients previously treated with concurrent ch emoradiation therapy were studied , a subset of 62 patients who were recruited e arlier in a randomized phase Ⅲ study designed to evaluate the effect of amifost ine. The radiotherapy regimen was 1.2 Gy/fraction, Bid to a total dose of 69.6 G y. In this study 19 and 20 patients were in the control arm and amifostine arm, respectively. The AE score, evaluated by the RTOG acute morbidity criteria, was collected for each treatment week and one month following radiotherapy. DVH of t he esophagus was computed. A multivariate random-effect logistic model was used to investigate the correlation between the incidence of AE and various dose-vo lume factors among these 39 patients. The variables analyzed included total tumo r dose (TD), the mean and maximum dose to esophagus, the volume of esophagus tre ated above certain dose, and the dose of the esophagus treated to certain volume .Results:Among the 39 patients studied, two patients of the amif ostine arm (11%) and six patients of the non-amifostine arm (30%) experienced g rade Ⅲ AE. Grade Ⅲ AE was first seen at week 4th after a cumulative tumor dose to 36 Gy. However after week 4, it did not increase significantly with dose. Th e cumulative TD and patient sensitivity were found to have the strongest and sta tistically significant influence on the risk of AE in all dose and volume factor s.Conclusions:The risk of severe (grade Ⅲ) AE was associated wit h the cumulative dose to tumor and intrinsic patient sensitivity. Due to the tim e course of the development of AE, the daily dose rate or the cumulative dose by the 4th week of the treatment may be more predicative for the risk of AE rather than the total dose from the entire treatment course. Current clinical practice in using the total dose to assess the normal-tissue toxicity may need to be ad justed to account for the onset time of the acute end-point.

Voiding dysfunction is a serious complication after spinal cord injury.Now we have no effective treatment to deal with it,related operations mainly belong to reconstructive methods without long-term certain results.Neuromodulation,as a kind of way to suppress overactive detrusor,supposes to be an effective method.This paper would discuss its origin,application of dorsal penile nerve modulation and its candidate mechanism to certify the feasibility of neuromodulation on spinal cord injury patients.

OBJECTIVE: To evaluate the relative factors influencing olfactory dysfunction in patients with chronic rhinosinusitis (CRS). METHOD: Visual analogue scale (VAS) was applied to measure the severity of olfactory dysfunction of 270 patients with CRS. Patients were divided into two groups, one was that the quality of life (QOL) of patients was affected by olfactory dysfunction (VAS > 5), the other was that without QOL affected by olfactory dysfunction (VAS ≤ 5). The association between age, gender, nasal polyps, allergic rhinitis, smoking history, early nasal surgery history and other clinical factors, and serum total IgE level, peripheral blood eosinophil count, peripheral blood mononuclear cell count and olfactory dysfunction was analyzed. RESULT: The number of patients with nasal polyps, allergic rhinitis, previous nasal surgeries, the level of serum total IgE, and the severity of edema were significantly increased in patients with impaired QOL associated with olfactory dysfunction (P < 0.05). Sex distribution, age, smoking history, deviation of nasal septum, eosinophil and mononuclear cell count did no statistically differ between the groups with and without impaired QOL associated with olfactory dysfunctions (P > 0.05). Serum total IgE increased (OR = 1.003, P < 0.01) and severe edema (OR = 2.483, P < 0.01) were the risk factors for the impairment of olfactory function, more notably for edema; whereas previous nasal surgeries was a protective factor (OR = 0.408, P < 0.01). CONCLUSION Sever edema and increased serum total IgE are risk factors, whereas previous nasal surgeries history is a protective factor for the olfactory dysfunction.
Chronic Disease ; Female ; Humans ; Leukocytes, Mononuclear ; Male ; Nasal Polyps ; Olfaction Disorders ; etiology ; Quality of Life ; Rhinitis ; complications ; immunology ; Rhinitis, Allergic ; complications ; immunology ; Risk Factors ; Sinusitis ; complications ; immunology ; Smell ; Smoking ; adverse effects

Due to lack of the practical technique to measure the biomechanical properties of the ocular cornea in vivo, clinical ophthalmologists have some difficulties in understanding the deformation mechanism of the cornea under the action of physiological intraocular pressures. Using Young's theory analysis of the corneal deformation during applanation tonometry, the relation between the elasticity moduli of the cornea and the applanated corneal area and the measured and true intraocular pressures can be obtained. A new applanation technique has been developed for measuring the biomechanical properties of the ocular cornea tissue in vivo, which can simultaneously acquire the data of the applanation area and displacement of the corneal deformation as well as the exerted applanation force on the cornea. Experimental results on a rabbit's eyeball demonstrated that the present technique could be used to measure the elasticity moduli and creep properties of the ocular cornea nondestructively in vivo.
Animals ; Biomechanical Phenomena ; Cornea ; Elastic Modulus ; Intraocular Pressure ; Muscles ; Rabbits ; Tonometry, Ocular

Esophageal Neoplasms ; metabolism ; pathology ; Female ; Humans ; Melanoma ; metabolism ; pathology ; Melanoma-Specific Antigens ; metabolism ; Middle Aged ; S100 Proteins ; metabolism

Objective To investigate the safety and long-term therapeutic results of anatomical hepatectomy for hepatocellular carcinoma (HCC).Methods 90 patients underwent anatomical hepatectomy from January,2003 to January,2010.The tumor size was ≤5 cm in 38 patients,and ＞5 cm in 52 patients.The tumor number was a single lesion in 58 patients,and multiple lesions in 32 patients.Cirrhosis was present in 46 patients (55.42％); cancer embolus was present in 34 patients (37.78％).There were 64 patients in Child-Pugh A and 26 patients in B.The operating time,blood loss and blood transfusion were recorded and analyzed.Complications and liver function were monitored after surgery.The Kaplan-Meier method was used to calculate the survival rates.Log-rank test was used to analyze factors associating with postoperative recurrence.Independent factors influencing tumor-free survival and overall survival were analyzed by Cox-model logistic regression.Result There was no perioperative death.The incidence of complications was 31.1％ (28/90).The recurrence rate was 51.1％ (46/90).The 1-,3-,5 year tumor-free survivals were 92.2％,67.3％ and 49.7％％00,respectively.Positive resection margin and satellite nodule were independent factors for recurrence (RR19.22,95 ％ confidence interval 5.85～63.17).The 1-,3-,5-year overall survivals were 94.4％,80.0％ and 60.0％,respectively.Positive resection margin and TNM were independent factors for overall survival (RR 2.013,95％ confidence interval 1.28～3.17).Conclusions Anatomical hepatectomy was a safe and efficacious procedure to treat HCC.Positive resection margin and TNM were independent factors associated with overall survival.Anatomical hepatectomy had the advantages in ensuring a lower rate of negative resection margin.