microRNAs are a class of highly conserved small non-coding RNAs with single-strand,which regulate their target mRNAs at post-transcriptional level.They have been shown to play an important role in the regulation of development of hemopoietic system malignancies.Evading apoptosis is a hallmark of tumorigenesis.In recent years,accumulative data have proved that aberrant expression of microRNAs participates in the regulation of many crucial pathways of apoptosis.By binding to their target mRNAs,microRNAs may inhibit apoptosis (e.g.miR-17-92 cluster,miR-21) or promote apoptosis (e.g.miR-15a/16-1,miR-150),which act as oncogene or tumor suppressor.In addition,the differential expression of microRNAs in lymphoma may provide new markers in determination of prognostic factors.Moreover,insights into microRNA expression in lymphoma may reveal potentially novel therapeutic targets.

The several questions in Theories of Acupuncture and Moxibustion of Different Schools, "the twelfth five-year plan" teaching material, are analyzed and discussed. The expression of DOU Han-qing on "playing a role of meridians, collaterals, qi and blood" is not so accurate, which is suggested to modify as "attaching the importance to needles". "Theory of heaven, human being and earth" "theory of acupuncture on qi regulation" and "the eight therapeutic methods in treatment of disease" in Jinzhenfu (Ode to Golden Needles) are valuable academically and suggested to be supplemented. The expression of XI Hong on "reinforcing and reducing technique by following or against the running course of meridian" and the expression of XU Feng on "the magic turtle eight techniques" are not concrete. It is required to elaborate them in detail. These questions are put forward and needed to discuss with the editors so as to perfect the teaching material.
Acupuncture ; education ; instrumentation ; Humans ; Moxibustion ; Teaching Materials

Objective To study the influence of HBV infection for gastromucous membrane in chronic hepatitis B and cirrhosis and its pathogenesis.Methods The liver biopsy,gastroscope,liver function and HBVM were detected at the same time in 60 patients with chronic hepatitis B and cirrhosis.HBsAg and HBcAg in the tissues of liver and gastromucous membrane were detected by SP immunohistochemistry.Results The damage of gastromucous membrane were found in 56 of 60 patients.Its damage degree was showed as moderate and severe.The other 34 showed mild and moderate damage(P

Adolescent ; Adult ; Child ; Chronic Disease ; Female ; Humans ; Male ; Middle Aged ; Mucin-5B ; biosynthesis ; Nasal Mucosa ; metabolism ; Sinusitis ; metabolism ; Young Adult

Objective To explore the current situation of nursing students' leadership,in order to improve the clinical leadership of nursing students and provide reference for nursing teaching.Methods In July 2016,a questionnaire survey of nursing students including undergraduate and junior college students in our hospital was conducted by using the Self Assessment Leadership Instrument.SPSS 17.0 was used to conduct the t test to investigate the nursing leadership differences between the two groups.Results The total score of nursing students was (114.68 ± 18.25),and the score of undergraduate students was higher than junior college students (t=8.13,P=0.000);In the dimensions of critical thinking,decision-making skill,interpersonal relationship,team spirit and working relationship,there were significant differences in the scores of undergraduate and junior college students with different levels of education (P＜0.05).Conclusion The level of leadership of nursing students is low.In the process of nursing students' education,we should carry out the leadership courses in the school and practice leadership in clinical clerkship,so that we can promote the improvement of nurses' leadership and promote the development of nursing science.

Objective To know the effects of air pollution on the activity of aryl hydrocarbon hydroxylase (AHH) in the placenta tissue of women in Taiyuan, Shanxi Province. Methods The decrement of BaP after the metabolic procedure was used as the indicator of AHH activity. 151 lying-in women were selected and the AHH activity in the placenta was determined by fluorescence spectrophotometer, the precooling EDTA was added in the determination to inactivate AHH and to stop the reaction completely in order to get more stable result. Results The AHH activity in the placenta tissue increased as the atmospheric particle concentration and the BaP concentration in the particles increased. Conclusion The air pollution may induce the AHH activity increase in the placenta tissue of pregnant women in Taiyuan. The AHH activity can be used as the biological monitoring indicator in the PAHs polluted areas.

Objective To study the relation between copper,copper-zinc ratio in blood and blood-fat only in the copper intake lower than the normal acceptable daily intake,and to provide a unified dosage evidence for copper multi-ways exposure.Methods Forty-two SD rats were divided into 7 groups randomly.The rats in one group among them as the normal control group were fed on the normal fodder and water,the other 6 groups were fed on special fodder without copper and deionized water and i.g.copper gluconate at doses of 0ADI(the acceptable daily intake of rat),1/625ADI(0.000 128 mg/ml),1/125ADI(0.000 64 mg/ml),1/25ADI(0.003 2 mg/ml),1/5ADI(0.016 mg/ml) and ADI(0.8 mg/ml),for 30 days.The activity of ceruloplasmin(CP),the content of copper,zinc in the blood and the level of total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL) and low density-lipoprotein(LDL) were determined.Results In the case of copper intake lower than the normal acceptable daily intake,the activity of CP in the blood of all treated rats were lower than the normal level(P

Objective To investigate the effects of artervenous fistula on structure and function of heart in patients with hemodialysis in the Second Clinical Hospital of Chinese Medical University from 2004 to 2005.Methods AVF、LAD、RVD、LVD、LVEDV、SV and EF were examined and analysed before and 8 weeks after AVF in 55 patients with hemodialysis.Results LAD、RVD、LVD、LVEDV after AVF increased significantly and EF reduced evidently after AVF.Conclusion AVF can cause extension of LAD、 RVD、 LVD and decrease of EF.

OBJECTIVE: To study airway reactivity and impulse oscillation (IOS)-measured airway resistance indicators of residents of Zhenhai industrial area in Ningbo city. METHOD: In the form of follow-up, both. airway reactivity and respiratory functions of populations in Zhenhai industrial zone (n = 215) and urban (n = 203) were measured, comparing difference degree between different regions. RESULT: Ninty-five of 215 cases in industrial area were identified as suspected airway hyperresponsiveness, but only 43 of 203 cases were in urban areas. Forty-seven of 95 cases (49.5%) in industrial zone were positive, while only 14 cases (32.6%) in urban. The proportions of people in the two regions on different types of airway hyperresponsiveness were significantly different (P < 0.01). All airway resistance indexes of urban populations were significantly lower than that of industrial zone (P < 0.05). CONCLUSION The prevalence of airway hyperresponsiveness and IOS airway resistance aspects of industrial area residents was higher than that of urban residents. Monitoring and evaluating the airway diseases, inflammatory lesions and respiratory function in the region were good for understanding the severe pollution in the local area in certain significance.
Air Pollution ; adverse effects ; Airway Resistance ; Cities ; Environment ; Humans ; Industry ; Oscillometry ; Respiratory Hypersensitivity ; physiopathology ; Respiratory System ; physiopathology

Objective: To assess the relationship between pre-transplantation α-fetoprotein messenger (AFP) RNA expression in peripheral blood with tumor recurrence and survival rate in HCC patients. Methods: Thirty-one HCC patients receiving in situ liver transplantation from Feb. 2003 to Feb. 2004 were included in this study. Real-time quantitative RT-PCR was used to determine the expression level of AFP RNA in peripheral blood of all patients. All the cases were followed up for tumor recurrence and survival rate. The SPSS 12.0 software was used to analyze the relationship between AFP mRNA expression with tumor recurrence and survival rate. Results: Ten of the 31 patients were positive of AFP mRNA, with the quantity being 57 to 10 400 copies/μg RNA (median value: 360 copies/ μg RNA). Patients' Child-pugh grade, tumor size, tumor number, and tumor Edmood grade were not related to pre-transplantation AFP mRNA expression. Patients of pTNM III-IV stages had a significantly higher AFP mRNA expression than those of pTNM I-II stages (P=0.001); patients with vascular invasion had a significantly higher expression than those without (P=0.029). Patients who were negative of AFP mRNA before transplantation had a significantly higher survival rate than those positive of AFP mRNA. Conclusion: The results suggest that the pre-transplantation levels of AFP mRNA in peripheral blood may be a risk factor for recurrence and/or metastasis after transplantation in HCC patients; it may also be an indicator for extra-hepatic micrometastasis before transplantation and can be used for predicting prognosis.