Chronic Disease ; Combined Modality Therapy ; Humans ; Research ; Sinusitis ; therapy

Environment ; Humans ; Rhinitis, Allergic ; epidemiology

Chronic Disease ; Humans ; Rhinitis ; Sinusitis

Child ; Guidelines as Topic ; Humans ; Rhinitis, Allergic, Perennial ; diagnosis ; therapy ; Rhinitis, Allergic, Seasonal ; diagnosis ; therapy

Humans ; Rhinitis ; classification

Child ; Humans ; Rhinitis, Allergic, Perennial ; diagnosis ; therapy

OBJECTIVE To observe the inhibition of the expression of HIF-1? and VEGF induced by LPS in primary human nasal epithelial cell (HNEC) by dexamethasone. METHODS Epithelial cells of nasal polyps (NP) and inferior turbinate (IT) were cultured without serum under stimulus of LPS 100 ng/ml, IL-1? 20 ng/ml, LPS 100 ng/ml +dexamethasone 13 ng/ml and IL-1? 20 ng/ml+ dexamethasone 13 ng/ml for 3h, 6h and 9h respectively. The expression of HIF-1?, VEGF protein and mRNA derived from epithelial cells was detected by immunocytochemistry and situ hybridization. RESULTS ①The expression of HIF-1? and VEGF increased under the stimulus of LPS and IL-1? with the increasing of time and concentration, especially under LPS 100 ng/ml for 6h (P

Multi-tragets are used for deep brain stimulation (DBS) to promote wakefulness, such as midbrain, thalamus, hypothalamus, etc. Lateral hypothalamic area may be one of the most potential tragets.

Child ; Humans ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial

Anaphylaxis ; Humans ; Hypersensitivity ; Rhinitis ; classification ; Rhinitis, Allergic, Perennial ; Rhinitis, Allergic, Seasonal ; Terminology as Topic