1.Hyperthermia differentially affects specific human stem cells and their differentiated derivatives.
Si WANG ; Fang CHENG ; Qianzhao JI ; Moshi SONG ; Zeming WU ; Yiyuan ZHANG ; Zhejun JI ; Huyi FENG ; Juan Carlos Izpisua BELMONTE ; Qi ZHOU ; Jing QU ; Wei LI ; Guang-Hui LIU ; Weiqi ZHANG
Protein & Cell 2022;13(8):615-622
2.Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis.
Jinghui LEI ; Xiaoyu JIANG ; Wei LI ; Jie REN ; Datao WANG ; Zhejun JI ; Zeming WU ; Fang CHENG ; Yusheng CAI ; Zheng-Rong YU ; Juan Carlos Izpisua BELMONTE ; Chunyi LI ; Guang-Hui LIU ; Weiqi ZHANG ; Jing QU ; Si WANG
Protein & Cell 2022;13(3):220-226
3.Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells.
Hezhen SHAN ; Lingling GENG ; Xiaoyu JIANG ; Moshi SONG ; Jianxun WANG ; Zunpeng LIU ; Xiao ZHUO ; Zeming WU ; Jianli HU ; Zhejun JI ; Si WANG ; Piu CHAN ; Jing QU ; Weiqi ZHANG ; Guang-Hui LIU
Protein & Cell 2022;13(7):532-539
4.Low-dose chloroquine treatment extends the lifespan of aged rats.
Wei LI ; Zhiran ZOU ; Yusheng CAI ; Kuan YANG ; Si WANG ; Zunpeng LIU ; Lingling GENG ; Qun CHU ; Zhejun JI ; Piu CHAN ; Guang-Hui LIU ; Moshi SONG ; Jing QU ; Weiqi ZHANG
Protein & Cell 2022;13(6):454-461
5.Single-cell transcriptomic atlas of mouse cochlear aging.
Guoqiang SUN ; Yandong ZHENG ; Xiaolong FU ; Weiqi ZHANG ; Jie REN ; Shuai MA ; Shuhui SUN ; Xiaojuan HE ; Qiaoran WANG ; Zhejun JI ; Fang CHENG ; Kaowen YAN ; Ziyi LIU ; Juan Carlos Izpisua BELMONTE ; Jing QU ; Si WANG ; Renjie CHAI ; Guang-Hui LIU
Protein & Cell 2023;14(3):180-201
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL.
Mice
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Animals
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Transcriptome
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Aging/metabolism*
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Cochlea
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Stria Vascularis
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Presbycusis
Result Analysis
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