Objective This study was conducted to ascertain whether study on carcinogenic potential of reflux juice from long-standing gastrectomy patients could clarify the relationship between duodenogastric reflux and gastric stump cancer. Methods A total of 48 reflux juice samples(11 Billroth Ⅰ,37 BillrothⅡ)were employed in our study.Ames test and MTT proliferation assay were carried out to evaluate the mutagenicity and proliferative activity of aspirates, respectively. Results There was no difference in mutagenicity of the samples in respect of surgical procedures(P＞0.05). While Billroth Ⅱ samples exhibited stronger proliferative activity than Billroth Ⅰ samples(P=0.751),In addition, the proliferative activity well correlated with pH of aspirates(rs=0.73,P＜0.001),but the mutagenicity failed to this correlation. Conclusion We confirm the duodenal reflux theory for the gastric stump cancer with the aspirates from long-standing postgastrectomy patients, and further suggest that proliferative activity of aspirates should be responsible for the high incidence of gastric cancer in the long-standing gastrectomy patients, thus roviding direct evidence for the etiology of the gastric stump cancer. Simultaneously closely endoscopic surveillance or postgastrectomy patients with moderate/severe dysplasia is highly recommended. In addition, to decrease the incidence of stump cancer effectively, it seems reasonable to perform reconstruction procedures(e.g,Roux-en-Y anastomosis)for those with severe duodenal reflux and to focus the chemoprevention of this cancer on proliferative activity of the reflux juice.

ObjectiveTo evaluate the diagnostic and therapeutic methods for hilar cholangiocarcinoma(HCC). Methods In 20 HCC patients serum CA19 9, CA242, CEA were determined preoperatively. A total of 57 HCC patients underwent surgery. Postoperatively 89% (51/57) patients were followed up. Results The sensitivity and specificity of CA19 9 for preoperative diagnosis were 78% and 90%, respectively. 47%(27/57) patients underwent radical resection with 1, 3 year survival rates of 96% and 32%. ConclusionThe results showed that CA19 9 is helpful for the diagnosis of hilar cholangiocarcinoma. Radical resection is effective for prolonging the long term survival in patients with HCC.

Peri-implantitis, characterized by inflammation of tissues around implants and gradual loss of supporting bone tissue, has become one of the main causes for implant failure. Thoroughly removing the plaque biofilm on the implant surface is the first principle in the treatment of peri-implantitis. For this reason, various decontamination methods have been proposed, which can be divided into 2 categories: Removing biofilm and killing microorganisms according to the effect of plaque biofilm on the implant surface. However, at present, there is no decontamination method that can completely remove the plaque biofilm on the implant surface, and it lacks of clinical recommended guidelines. To understand the advantages and disadvantages, effectiveness and safety for different implant surface decontamination methods is of great significance to guide the clinical selection for peri-implantitis treatment.
Bone and Bones ; Decontamination ; Dental Implants ; Humans ; Inflammation ; Peri-Implantitis/therapy* ; Prostheses and Implants