1.Comparison of clinical efficacy of small incision extracapsular cataract extraction and phacoemulsification
Chinese Journal of Postgraduates of Medicine 2011;34(15):26-28
Objective To compare the effect of extracapsular cataract extraction and phacoemulsification. Methods Three hundred and twenty-six cases (360 eyes) of senile cataract were divided into two groups by random digits table with 163 cases (180 eyes) in each. One group underwent phacoemulsification (phacoemulsification group),and the other group underwent extracapsular cataract extraction with small incision(no-phacoemulsifieation group). A comparison was carried out between the two groups of the vision and complications after operation. Results In phacoemulsification group,7 d after operation 18.33%(33/180)had 0.4 or less in vision,66.11%( 119/180) were 0.5-0.9,15.56%(28/180) were 1.0 or better. In no-phacoemulsification group,7 d after operation, 18.89% (34/180) were 0.4 or less in vision,66.67% (120/180) were 0.5-0.9,14.44% (26/180) were 1.0 or better. During operation,posterior capsular ruptured and vitreous prolapsed in 4.44% (8/180) in phacoemulsification group and 3.33%(6/180) in no-phacoemulsification group. Corneal edema:there were 16.11%(29/180) in phacoemulsification group and 17.22%(31/180) in no-phacoemulsification group. The curative effect between the two kinds of operation mentioned above was almost the same and had no significant difference (P >0.05). Conclusion The no-phacoemulsification is simple and economical, wihch is suitable for basic hospitals.
2.Recent research progress in the subjective visual perception during cataract surgery
Chinese Journal of Experimental Ophthalmology 2012;30(9):853-856
Subjective visual perceptions experienced by patients during cataract surgery under local anesthesia have been given more and more attention now.Intraoperative visual experiences,including non-light perception,light perception,one or more color sensation,flash,movement,instrument,hands or fingers of surgeon etc.,are complained in parts of patients.These sensations and experience often lead to a fear of patient.Being aware of these intraoperative sensations of fear from patient is necessary for us to take the preventing strategy in advance.In addition,counseling of these patients prior to surgery may alleviate fears and improve the satisfaction of patient with surgery outcome.This paper reviewed the current studies on this phenomenon,discussed its clinical implications and possible mechanism,and suggested novel approaches to reduce its negative impact on the surgery.
3.A randomized controlled clinical study on a new quinolone,gatifloxacin, in the treatment of respiratory tract infections
Journal of Chongqing Medical University 2003;0(06):-
Objective:To evaluate the safety and efficacy of domestic intravenous gatifloxacin in the treatment of respiratory tract infections.Methods:A multicenter,double-blind,randomized controlled clinical trials of intravenous gatifloxacin and levofloxacin on patients with respiratory tract infections were conducted.The regimen of the two groups were 0.2g,twice daily,7~14days.Both drugs were given intravenously.Results:In this trial,40 patients were enrolled in gatifloxacin group,39 patients were enrolled in levofloxacin group.The overall efficacy rates and cure rate in trial and control group were 95%,65% and 94.87%,64.1% respectively.The bacterial clearance rates were 86.8% and 81.1% respectively in two groups.The adverse drug reaction rates were 7.5% and 10.2% in trial and control group respectively.There were no statistically significant differences in the above results between the two groups.The activity of gatifloxacin against gram-positive organisms was generally higher than that of the other 4 antibacterial agents.Antibacterial activity of gatifloxacin against gram-negtive bacterium was similar or stronger than the other antibacterial agents.Conclusion:The results suggest that domestic gatifloxacin injection with powerful antibacterial activity and wide spectrum is a highly effective and safe broad-spectrum new quinolone in treating respiratory tract infections.
4.A multi-center randomized contorlled clinical trial of doxycycline versus azithromycin injection in treatment of urinary tract infections.
Journal of Chongqing Medical University 1986;0(04):-
Objective: To evaluate the safety and efficacy of domestic intravenous doxycycline in the treatment of urinary tract infections.Methods:A multicenter,double-blind,randomized controlled clinical trial of intravenous doxycycline and azithromycin on patients with urinary tract infections were conducted.The dosage of doxycycline was 0.2g,once daily,for 5~12d and that of azithromycin was 0.5g,once daily,for 5~12d.Both drugs were given intravenously.Results: In this trial,62 patients were enrolled in doxycycline group,and 60 were enrolled in azithromycin group.The overall efficacy rates and cure rate in trial and control group were 100%,90.32% and 73.33%,95% respectively.There was statistical significant difference in the cure rates between the two groups.The bacterial clearance rates in two groups were 92.5% and 88.9% respectively.The adverse drug reaction rates were7.9% and6.7% respectively.There were no statistical significant differences in the above results between the two groups.The activity of doxycycline against gram-positive organisms was generally higher than that of the other 5 antibacterial agents.Antibacterial activity of doxycycline against gram-negtive bacterium was similar to or stronger than the other antibacterial agents.Conclusion: The results suggest that domestic doxycycline injection with powerful antibacterial activity and wide spectrum is highly effective in treating urinary tract infections.
5.Randomized contorl clinical study on safety and efficacy of domestic cefepime in the treatment of lower-respiratory tract bacterial infections
Journal of Chongqing Medical University 1986;0(03):-
Objective:To evaluate the safety and efficacy of domestic cefepime in the treatment of lower-respiratory tract bacterial infections.Methods:A double-blind,randomized control clinical trial of intravenous cefepime on patients with lower-respiratory tract bacterial infections were conducted.The regimen of the two groups were 2g,twice daily for 7 to14ds.Both drugs were given intravenously.Results:In this trial,30 patients were enrolled in trial group and other 30 patients were enrolled in control group.The overall efficacy rates and cure rate in trial and control group were 93.33%?63.33% and 96.67%?70% respectively.The bacterial clearance rates were 96% and 100% respectively,and the adverse drug reaction rates were 3.3% and 0%. There was no statistical significant differences in the above results between the two groups.The activity of cefepime against gram-positive organisms was generally higher than that of the other 4 antibacterial agents.Conclusion:The results suggested that demostic cefepime with powerful antibacterial activity and wide spectrum has the same safety and efficacy as imported one in treating lower-respiratory tract bacterial infections.
6.Several Problems in Quality Control of PACS
Chinese Medical Equipment Journal 2004;0(08):-
Objective To discover the main points of PACS quality control through basic study and advance some solution ways which include hardware and software improving. Methods Combined computer and network tech with hardware and software,like tech of network security,to increase the validity of PACS quality control. Results The archives and communications could be more accurate and safe by use of hardware and software and ROC theory. Conclusion The importance of quality control of PACS in the practical work is progressing and latest tech of hardware and software should be used to increase the quality control of PACS.
7.Iron metabolism and oncogenesis
Journal of International Oncology 2010;37(8):570-572
Iron metabolism is involved in cancer initiation, progression, metastasis, and angiogenesis.Ferritin,ferritin receptor,transferrin, and transferrin receptor are often overexpressed in cancers. Not only iron deprivation can inhibit the growth of cancers,but also may suppress matrix metalloproteinases-related metastasis.
8.Mesenchymal stem cells as cellular vehicles for tumor gene therapy
Journal of International Oncology 2010;37(6):425-428
The conventional approach of systemic viral gene delivery is often associated with limited therapeutic efficacy and toxicity because of a lack of tumor specificity. Mesenchymal stem cells have the tumortracking abilities which provide possibility that the stable and high level of anti- cancer gene expression could be acquired within local tumor and a novel approach for better tumor-targeted gene delivery.
9.Citations of original foreign language books in doctorial dissertations
Chinese Journal of Medical Library and Information Science 2015;(8):34-38
The citations of original foreign language books in doctorial dissertations of Suzhou University in 2013 were analyzed,which showed that the number of cited original foreign language books on humanities and social sciences was greater than that on other science, the cited books were not limited to those that were recently published, the number of cited original foreign language books published by university press was greater than that published by other publishers. Suggestions were put forward for improving the acquisition of original foreign language books.
10.Association of mild cognitive impairment with coronary artery disease in elderly patients
Chinese Journal of Practical Nursing 2017;33(2):94-97
Objective To investigate the relationship between coronary artery disease, other vascular risk factors and mild cognitive impairment in elderly patients. Methods A total of 196 inpatients were collected from the departments of cardiovascular internal medicine from April to September 2015.The unified questionnaires of cognitive status and standardized survey were developed. The patients were divided into 133 cases of mild cognitive impairment and 63 cases of cognitively normal by Montreal Cognitive Assessment Scale. The patients were divided into 79 cases of coronary heart disease and 117 cases of negative control by coronary angiography. Coronary artery disease and other vascular risk factors for mild cognitive impairment were analyzed. Results The levels of education and proportion of coronary heart disease were (9.23 ± 4.34) years and 45.9%(61/133) in mild cognitive impairment patients, and (12.27 ± 3.79) years and 28.6%(18/63) in cognitively normal patients. There were significant differences between the two(t=4.77, P<0.05,χ2=5.31, P<0.05). Multivariate Logistic regression analysis showed that degree of education was a protective factor for mild cognitive impairment with odds ratio ( OR) 0.86, 95%confidence interval (CI) 0.77 to 0.91 and P=0.00. Coronary heart disease was an independent risk factor for mild cognitive impairment (OR=2.02, 95%CI 1.03 to 4.00; P = 0.04) . The total scores of Montreal Cognitive Assessment Scale and delayed memory were (20.9±4.8), (22.4±5.6) points and (2.1± 1.6), (2.6 ± 1.8) points in coronary heart disease and negative control patients. There were significant differences between the two (t=1.98, 4.77, all P<0.05). Conclusions The degree of education is a protective factor for mild cognitive impairment. Coronary heart disease is an independent risk factor for mild cognitive impairment, and it mainly impairs delayed memory ability.