Objective To understand the prevalence and sub‐genotypes distribution situation of high risk human papillomavirus (HPV) infection in the gynecological outpatient department in Beijing area in order to provide the reference basis for the prevention and treatment of HPV infection and cervical cancer .Methods The detection results of 13 kinds of high risk HPV genotypes among 1 294 women in the gynecological outpatient department of this hospital from January 2013 to May 2014 were performed the retro‐spective analysis for comparing the epidemiological characteristics of different HPV genotypes .The SPSS17 .0 software was adopted to perform the statistical analysis .Results Among 1 294 detected women ,HPV‐58 ,HPV‐16 and HPV‐52 were most common ,the detection rates were 10 .5% ,9 .2% and 8 .2% respectively .Among various age groups ,the 30 - < 40 years group had the highest HPV detection rate(39 .9% ) ,followed by the 40 - < 50 years group and the ≥ 60 years group ,but the difference among them had no statistically significance (P> 0 .05) .Conclusion The women going to the local outpatient department have the higher prevalence of high risk HPV infection .The intensity of HPV screening should be strengthened in order to provide the fundamental basis for the prevention and treatment of HPV related diseases .

OBJECTIVETo minimize of the radiation dose of cardiovascular CT angiography (CTA) imaging while preserving the image quality.

METHODSTo reduce the radiation dose in CTA imaging, the normal-dose scan induced non-local means (ndiNLM) algorithm was adapted for low-mAs scanned CTA image restoration by using the previous scanned high-quality image.

RESULTSQualitative and quantitative evaluations were carried out on both simulated phantom and clinical CTA scans in terms of accuracy and resolution properties. Compared to the original NLM algorithm, the ndiNLM method could achieve noticeable gains in terms of noise-induced artifacts suppression and enhanced structure preservation.

CONCLUSIONThe ndiNLM algorithm is a potential useful technique to reduce the radiation dose in CTA imaging.

OBJECTIVETo compare two methods for threshold selection in Huber regularization for low-dose computed tomography imaging.

METHODSHuber regularization-based iterative reconstruction (IR) approach was adopted for low-dose CT image reconstruction and the threshold of Huber regularization was selected based on global versus local edge-detecting operators.

RESULTSThe experimental results on the simulation data demonstrated that both of the two threshold selection methods in Huber regularization could yield remarkable gains in terms of noise suppression and artifact removal.

CONCLUSIONBoth of the two methods for threshold selection in Huber regularization can yield high-quality images in low-dose CT image iterative reconstruction.

OBJECTIVETo develop a computed tomography myocardial perfusion (CT-MP) deconvolution algorithm by incorporating high-dimension total variation (HDTV) regularization.

METHODSA perfusion deconvolution model was formulated for the low-dose CT-MPI data, followed by HDTV regularization to regularize the consistency of the solution by fusing the spatial correlation of the vascular structure and the temporal continuation of the blood flow signal.

RESULTSBoth qualitative and quantitative studies were conducted using XCAT and pig myocardial perfusion data to evaluate the present algorithm. The experimental results showed that this algorithm achieved hemodynamic parameter maps with better performances than the existing methods in terms of streak-artifacts suppression, noise-resolution tradeoff, and diagnosis structure preservation.

CONCLUSIONThe proposed algorithm can achieve high-quality hemodynamic parameter maps in low-dose CT-MPI.

Objective:To analyze the efficacy and safety of enzyme therapy in late-onset Pompe disease (LOPD) patients, so as to provide reference for the treatment and prognosis of LOPD.Methods:The effect of α-glucosidase (GAA) on a patient diagnosed with LOPD in the Affiliated Hospital of Jining Medical University was observed and analyzed. Besides, literature related to enzyme therapy in LOPD patients were searched in PubMed, Web of Science, Medline databases. Twenty-one studies containing clinical data from 910 LOPD patients related to enzyme therapy were finally included for analysis.Results:The patient developed muscle weakness since he was 16 years old. The GAA activity in peripheral blood was 0. Electromyography suggested myogenic lesions in both lower extremities. Compound heterozygous mutations of GAA gene were found by next- generation sequencing. Muscle biopsy revealed characteristic vacuolar changes. After eight years of diagnosis, the patient was given enzyme therapy for 18.5 months, 20 times in total. The symptoms of muscle weakness were slightly improved in the early stages of treatment without obvious adverse reactions. Most of the 910 LOPD patients were stabilized or had improved muscular and (or) respiratory function following treatment with GAA.Conclusion:GAA treatment is effective and well tolerated. In patients with advanced severe LOPD, enzyme replacement therapy remains effective even years after onset.

Objective To minimize of the radiation dose of cardiovascular CT angiography (CTA) imaging while preserving the image quality. Methods To reduce the radiation dose in CTA imaging, the normal-dose scan induced non-local means (ndiNLM) algorithm was adapted for low-mAs scanned CTA image restoration by using the previous scanned high-quality image. Results Qualitative and quantitative evaluations were carried out on both simulated phantom and clinical CTA scans in terms of accuracy and resolution properties. Compared to the original NLM algorithm, the ndiNLM method could achieve noticeable gains in terms of noise-induced artifacts suppression and enhanced structure preservation. Conclusion The ndiNLM algorithm is a potential useful technique to reduce the radiation dose in CTA imaging.

Objective To minimize of the radiation dose of cardiovascular CT angiography (CTA) imaging while preserving the image quality. Methods To reduce the radiation dose in CTA imaging, the normal-dose scan induced non-local means (ndiNLM) algorithm was adapted for low-mAs scanned CTA image restoration by using the previous scanned high-quality image. Results Qualitative and quantitative evaluations were carried out on both simulated phantom and clinical CTA scans in terms of accuracy and resolution properties. Compared to the original NLM algorithm, the ndiNLM method could achieve noticeable gains in terms of noise-induced artifacts suppression and enhanced structure preservation. Conclusion The ndiNLM algorithm is a potential useful technique to reduce the radiation dose in CTA imaging.

Objective To compare two methods for threshold selection in Huber regularization for low-dose computed tomography imaging. Methods Huber regularization-based iterative reconstruction (IR) approach was adopted for low-dose CT image reconstruction and the threshold of Huber regularization was selected based on global versus local edge-detecting operators. Results The experimental results on the simulation data demonstrated that both of the two threshold selection methods in Huber regularization could yield remarkable gains in terms of noise suppression and artifact removal. Conclusion Both of the two methods for threshold selection in Huber regularization can yield high-quality images in low-dose CT image iterative reconstruction.

Objective To compare two methods for threshold selection in Huber regularization for low-dose computed tomography imaging. Methods Huber regularization-based iterative reconstruction (IR) approach was adopted for low-dose CT image reconstruction and the threshold of Huber regularization was selected based on global versus local edge-detecting operators. Results The experimental results on the simulation data demonstrated that both of the two threshold selection methods in Huber regularization could yield remarkable gains in terms of noise suppression and artifact removal. Conclusion Both of the two methods for threshold selection in Huber regularization can yield high-quality images in low-dose CT image iterative reconstruction.

Objective:To investigate the association between gestational blood pressure and neurodevelopment in 2-year-old children.Methods:Based on the"Wuhan Healthy Baby Birth Cohort", 3 754 mother-infant pairs were enrolled in this study. Based on multiple blood pressure measurements during pregnancy, the mean, cumulative, and variability of blood pressure throughout the entire pregnancy and each trimester were calculated. Blood pressure variability was evaluated using standard deviation (SD), coefficient of variability (CV), and variability independent of mean (VIM). Follow-up testing of neurodevelopment in infants and young children at the age of two was conducted to obtain the Mental Development Index (MDI) and the Psychomotor Development Index (PDI). The multivariate linear regression and generalized estimation equation were used to analyze the association between gestational blood pressure data and neurodevelopmental index.Results:The age of 3 754 pregnant women was (29.1±3.6) years, with a pre-pregnancy BMI of (20.9±2.7) kg/m2 and a gestational age of (39.3±1.2) weeks. The birth weight of 3 754 children was (3 330.9±397.7) grams, and the birth length was (50.3±1.6) centimeters. The results of the multivariate linear regression analysis showed that after adjusting for relevant confounding factors, the mean blood pressure, cumulative blood pressure, standard deviation of blood pressure, coefficient of variation of blood pressure, independent blood pressure variability of systolic blood pressure, diastolic blood pressure, and pulse pressure throughout pregnancy were negatively associated with the MDI and PDI scores of 2-year-old children. The analysis results of the generalized estimation equation showed that after adjusting for relevant confounding factors, the average systolic blood pressure in the first, second, and third trimesters was negatively associated with MDI/PDI. The negative association between cumulative blood pressure and MDI/PDI was only found in the first trimester. The negative association between blood pressure variation during pregnancy and MDI/PDI was mainly concentrated in the second and third trimesters.Conclusion:There is a negative association between gestational blood pressure and the neurodevelopmental index of 2-year-old children.